Publication:
Evaluation of late effects of postoperative radiotherapy in patients with medulloblastoma

dc.contributor.authorKaradağ, Oya
dc.contributor.authorDemiröz-Abakay, Candan
dc.contributor.authorÖzkan, Lütfi
dc.contributor.authorSağlam, Halil
dc.contributor.authorDemirkaya, Metin
dc.contributor.buuauthorDEMİRÖZ ABAKAY, CANDAN
dc.contributor.buuauthorÖzkan, Lütfi
dc.contributor.buuauthorSAĞLAM, HALİL
dc.contributor.buuauthorDemirkaya, Metin
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Pediatrik Endokrinoloji Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.
dc.contributor.orcid0000-0003-0710-5422
dc.contributor.researcheridGLN-8241-2022
dc.contributor.researcheridC-7392-2019
dc.contributor.researcheridETY-3982-2022
dc.contributor.researcheridJGQ-9310-2023
dc.contributor.researcheridEUG-4353-2022
dc.date.accessioned2024-08-05T10:07:08Z
dc.date.available2024-08-05T10:07:08Z
dc.date.issued2015-03-01
dc.description.abstractWe aimed to evaluate long-term toxicity in children with medulloblastoma treated with postoperative radiotherapy (RT).This study included 21 patients aged 4-16 who had been diagnosed with medulloblastoma. All of the patients in the study received postoperative craniospinal RT. Postoperative RT followed by chemotherapy was the treatment protocol. A total of 13 patients (62%) received chemotherapy concurrently with RT.Overall survival was 50 months (range, 1-169 months) and disease-free survival was 39 months (range, 4-171 months). In the data analysis, the heights of 11 patients (91.6%) were found to be below 50% on the height curve, and 8 (66.6%) patients had weights below 50% on the weight curve. Mean sitting height was 72.58 +/- 6.33 cm, and this was statistically correlated with parameters such as LH level (p=0.037), testosterone level (p=0.020), height (p=0.002), weight (p=0.033) and age at diagnosis (p=0.002).Radiation therapy for medulloblastoma seems to have a late toxic effect on long-term survivors. With the improving survival rate of medulloblastoma patients, RT doses should be as low as possible without sacrificing efficacy.
dc.identifier.endpage171
dc.identifier.issn0041-4301
dc.identifier.issue2
dc.identifier.startpage167
dc.identifier.urihttps://turkjpediatr.org/article/view/1213
dc.identifier.urihttps://hdl.handle.net/11452/43704
dc.identifier.volume57
dc.identifier.wos000367570300009
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherTurkish J Pediatrics
dc.relation.journalTurkish Journal of Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCraniospinal radiation-therapy
dc.subjectProspective randomized-trial
dc.subjectGrowth-hormone deficiency
dc.subjectOf-pediatric-oncology
dc.subjectChildhood medulloblastoma
dc.subjectAdjuvant chemotherapy
dc.subjectInternational-society
dc.subjectRisk medulloblastoma
dc.subjectCranial irradiation
dc.subjectThyroid-dysfunction
dc.subjectPediatric medulloblastoma
dc.subjectRadiotherapy
dc.subjectLate effects
dc.subjectPediatrics
dc.titleEvaluation of late effects of postoperative radiotherapy in patients with medulloblastoma
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication42e5fe2e-88cd-4083-9ed8-28b4cfa73e9d
relation.isAuthorOfPublication0ea2245f-bcba-4a84-b68a-fdbc43ac8913
relation.isAuthorOfPublication.latestForDiscovery42e5fe2e-88cd-4083-9ed8-28b4cfa73e9d

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