Publication: Evaluation of late effects of postoperative radiotherapy in patients with medulloblastoma
dc.contributor.author | Karadağ, Oya | |
dc.contributor.author | Demiröz-Abakay, Candan | |
dc.contributor.author | Özkan, Lütfi | |
dc.contributor.author | Sağlam, Halil | |
dc.contributor.author | Demirkaya, Metin | |
dc.contributor.buuauthor | DEMİRÖZ ABAKAY, CANDAN | |
dc.contributor.buuauthor | Özkan, Lütfi | |
dc.contributor.buuauthor | SAĞLAM, HALİL | |
dc.contributor.buuauthor | Demirkaya, Metin | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı. | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Endokrinoloji Anabilim Dalı. | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı. | |
dc.contributor.orcid | 0000-0003-0710-5422 | |
dc.contributor.researcherid | GLN-8241-2022 | |
dc.contributor.researcherid | C-7392-2019 | |
dc.contributor.researcherid | ETY-3982-2022 | |
dc.contributor.researcherid | JGQ-9310-2023 | |
dc.contributor.researcherid | EUG-4353-2022 | |
dc.date.accessioned | 2024-08-05T10:07:08Z | |
dc.date.available | 2024-08-05T10:07:08Z | |
dc.date.issued | 2015-03-01 | |
dc.description.abstract | We aimed to evaluate long-term toxicity in children with medulloblastoma treated with postoperative radiotherapy (RT).This study included 21 patients aged 4-16 who had been diagnosed with medulloblastoma. All of the patients in the study received postoperative craniospinal RT. Postoperative RT followed by chemotherapy was the treatment protocol. A total of 13 patients (62%) received chemotherapy concurrently with RT.Overall survival was 50 months (range, 1-169 months) and disease-free survival was 39 months (range, 4-171 months). In the data analysis, the heights of 11 patients (91.6%) were found to be below 50% on the height curve, and 8 (66.6%) patients had weights below 50% on the weight curve. Mean sitting height was 72.58 +/- 6.33 cm, and this was statistically correlated with parameters such as LH level (p=0.037), testosterone level (p=0.020), height (p=0.002), weight (p=0.033) and age at diagnosis (p=0.002).Radiation therapy for medulloblastoma seems to have a late toxic effect on long-term survivors. With the improving survival rate of medulloblastoma patients, RT doses should be as low as possible without sacrificing efficacy. | |
dc.identifier.endpage | 171 | |
dc.identifier.issn | 0041-4301 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 167 | |
dc.identifier.uri | https://turkjpediatr.org/article/view/1213 | |
dc.identifier.uri | https://hdl.handle.net/11452/43704 | |
dc.identifier.volume | 57 | |
dc.identifier.wos | 000367570300009 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Turkish J Pediatrics | |
dc.relation.journal | Turkish Journal of Pediatrics | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Craniospinal radiation-therapy | |
dc.subject | Prospective randomized-trial | |
dc.subject | Growth-hormone deficiency | |
dc.subject | Of-pediatric-oncology | |
dc.subject | Childhood medulloblastoma | |
dc.subject | Adjuvant chemotherapy | |
dc.subject | International-society | |
dc.subject | Risk medulloblastoma | |
dc.subject | Cranial irradiation | |
dc.subject | Thyroid-dysfunction | |
dc.subject | Pediatric medulloblastoma | |
dc.subject | Radiotherapy | |
dc.subject | Late effects | |
dc.subject | Pediatrics | |
dc.title | Evaluation of late effects of postoperative radiotherapy in patients with medulloblastoma | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 42e5fe2e-88cd-4083-9ed8-28b4cfa73e9d | |
relation.isAuthorOfPublication | 0ea2245f-bcba-4a84-b68a-fdbc43ac8913 | |
relation.isAuthorOfPublication.latestForDiscovery | 42e5fe2e-88cd-4083-9ed8-28b4cfa73e9d |