Publication:
Serum cancer from lung-6: Promising biomarker to differentiate cpfe from ipf

dc.contributor.buuauthorUzaslan, Esra
dc.contributor.buuauthorDEMİRDÖĞEN, EZGİ
dc.contributor.buuauthorUZASLAN, AYŞE ESRA
dc.contributor.buuauthorGÖREK DİLEKTAŞLI, ASLI
dc.contributor.buuauthorÖZKAYA, GÜVEN
dc.contributor.buuauthorDilektaşlı, Aslı Görek
dc.contributor.buuauthorÖztürk, Nilüfer Aylin Acet
dc.contributor.buuauthorKaradağ, Mehmet
dc.contributor.buuauthorKARADAĞ, MEHMET
dc.contributor.buuauthorACET ÖZTÜRK, NİLÜFER AYLİN
dc.contributor.buuauthorYEŞİLBURSA, DİLEK
dc.contributor.buuauthorYeşilbursa, Dilek
dc.contributor.buuauthorBudak, Ferah
dc.contributor.buuauthorBUDAK, FERAH
dc.contributor.buuauthorÖztürk, Alper
dc.contributor.buuauthorUrsavaş, Ahmet
dc.contributor.buuauthorCOŞKUN, NECMİYE FUNDA
dc.contributor.buuauthorURSAVAŞ, AHMET
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/İmmunoloji Anabilim Dalı.
dc.contributor.orcid0000-0002-7400-9089
dc.contributor.orcid0000-0001-7099-9647
dc.contributor.orcid0000-0002-6375-1472
dc.contributor.orcid0000-0001-7625-9148
dc.contributor.orcid0000-0003-3604-8826
dc.contributor.orcid0000-0003-0297-846X
dc.contributor.orcid0000-0002-9027-1132
dc.contributor.researcheridAAD-1271-2019
dc.contributor.researcheridJPK-7012-2023
dc.contributor.researcheridIZP-9398-2023
dc.contributor.researcheridA-4421-2016
dc.contributor.researcheridF-4657-2014
dc.contributor.researcheridAAI-3169-2021
dc.contributor.researcheridAAG-8744-2021
dc.date.accessioned2024-09-05T08:57:49Z
dc.date.available2024-09-05T08:57:49Z
dc.date.issued2022-01-01
dc.description.abstractBackground: Combined pulmonary fibrosis and emphysema (CPFE) has been recognised as a phe-notype of pulmonary fibrosis. We aimed to compare serum surfactant protein-A (SP-A), surfactant protein-D (SP-D) and Krebs von den Lungen-6 (KL-6) levels, functional parameters, in CPFE and IPF (idiopathic pul-monary fibrosis) patients. Methods: Patients diagnosed with ???CPFE??? and ???IPF??? were consecutively included in 6 months as two groups. The patients with connective tissue diseases are excluded. Results: In this study, 47 patients (41 males, 6 females) with CPFE (n = 21) and IPF (n = 26) with a mean age of 70.12 ?? 8.75 were evaluated. CPFE patients were older, had more intense smoking history, had lower DLCO/VA, lower FVC, and worse six-minute walking distance than the IPF group (p=0.005, p=0.027, p=0.02, p<0.001, p=0.001, respec-tively). Serum KL-6 levels were higher in CPFE group compared to IPF group [264.70 U/ml (228.90-786) vs 233.60 (101.8-425.4), p<0.001]. Serum KL-6 levels of 245.4 U/ml and higher have 81% sensitivity and 73% specificity for the discrimination of CPFE from IPF. Conclusions: Our study has shown that serum KL-6 level is a promising biomarker to differentiate CPFE from IPF. In CPFE cases respiratory and functional parameters are worse than those of pure fibrosis cases.
dc.identifier.doi10.36141/svdld.v39i4.11344
dc.identifier.issn1124-0490
dc.identifier.issue4
dc.identifier.urihttps://doi.org/10.36141/svdld.v39i4.11344
dc.identifier.urihttps://hdl.handle.net/11452/44338
dc.identifier.volume39
dc.identifier.wos000911483000002
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherMattioli 1885
dc.relation.journalSarcoidosis Vasculitis And Diffuse Lung Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIdiopathic pulmonary-fibrosis
dc.subjectSurfactant protein-a
dc.subjectQuality-of-life
dc.subjectCirculating kl-6
dc.subjectEmphysema
dc.subjectHypertension
dc.subjectMarkers
dc.subjectCombined pulmonary fibrosis emphysema
dc.subjectIdiopathic pulmonary fibrosis
dc.subjectKrebs von den lungen-6
dc.subjectSurfactant protein-a
dc.subjectSurfactant protein-d
dc.subjectPulmonary function tests
dc.subjectEchocardiography
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectRespiratory system
dc.titleSerum cancer from lung-6: Promising biomarker to differentiate cpfe from ipf
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery80df98cb-7a8e-4a6c-86c1-65dfe8f4e962

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