Publication: Serum cancer from lung-6: Promising biomarker to differentiate cpfe from ipf
dc.contributor.buuauthor | Uzaslan, Esra | |
dc.contributor.buuauthor | DEMİRDÖĞEN, EZGİ | |
dc.contributor.buuauthor | UZASLAN, AYŞE ESRA | |
dc.contributor.buuauthor | GÖREK DİLEKTAŞLI, ASLI | |
dc.contributor.buuauthor | ÖZKAYA, GÜVEN | |
dc.contributor.buuauthor | Dilektaşlı, Aslı Görek | |
dc.contributor.buuauthor | Öztürk, Nilüfer Aylin Acet | |
dc.contributor.buuauthor | Karadağ, Mehmet | |
dc.contributor.buuauthor | KARADAĞ, MEHMET | |
dc.contributor.buuauthor | ACET ÖZTÜRK, NİLÜFER AYLİN | |
dc.contributor.buuauthor | YEŞİLBURSA, DİLEK | |
dc.contributor.buuauthor | Yeşilbursa, Dilek | |
dc.contributor.buuauthor | Budak, Ferah | |
dc.contributor.buuauthor | BUDAK, FERAH | |
dc.contributor.buuauthor | Öztürk, Alper | |
dc.contributor.buuauthor | Ursavaş, Ahmet | |
dc.contributor.buuauthor | COŞKUN, NECMİYE FUNDA | |
dc.contributor.buuauthor | URSAVAŞ, AHMET | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmunoloji Anabilim Dalı. | |
dc.contributor.orcid | 0000-0002-7400-9089 | |
dc.contributor.orcid | 0000-0001-7099-9647 | |
dc.contributor.orcid | 0000-0002-6375-1472 | |
dc.contributor.orcid | 0000-0001-7625-9148 | |
dc.contributor.orcid | 0000-0003-3604-8826 | |
dc.contributor.orcid | 0000-0003-0297-846X | |
dc.contributor.orcid | 0000-0002-9027-1132 | |
dc.contributor.researcherid | AAD-1271-2019 | |
dc.contributor.researcherid | JPK-7012-2023 | |
dc.contributor.researcherid | IZP-9398-2023 | |
dc.contributor.researcherid | A-4421-2016 | |
dc.contributor.researcherid | F-4657-2014 | |
dc.contributor.researcherid | AAI-3169-2021 | |
dc.contributor.researcherid | AAG-8744-2021 | |
dc.date.accessioned | 2024-09-05T08:57:49Z | |
dc.date.available | 2024-09-05T08:57:49Z | |
dc.date.issued | 2022-01-01 | |
dc.description.abstract | Background: Combined pulmonary fibrosis and emphysema (CPFE) has been recognised as a phe-notype of pulmonary fibrosis. We aimed to compare serum surfactant protein-A (SP-A), surfactant protein-D (SP-D) and Krebs von den Lungen-6 (KL-6) levels, functional parameters, in CPFE and IPF (idiopathic pul-monary fibrosis) patients. Methods: Patients diagnosed with ???CPFE??? and ???IPF??? were consecutively included in 6 months as two groups. The patients with connective tissue diseases are excluded. Results: In this study, 47 patients (41 males, 6 females) with CPFE (n = 21) and IPF (n = 26) with a mean age of 70.12 ?? 8.75 were evaluated. CPFE patients were older, had more intense smoking history, had lower DLCO/VA, lower FVC, and worse six-minute walking distance than the IPF group (p=0.005, p=0.027, p=0.02, p<0.001, p=0.001, respec-tively). Serum KL-6 levels were higher in CPFE group compared to IPF group [264.70 U/ml (228.90-786) vs 233.60 (101.8-425.4), p<0.001]. Serum KL-6 levels of 245.4 U/ml and higher have 81% sensitivity and 73% specificity for the discrimination of CPFE from IPF. Conclusions: Our study has shown that serum KL-6 level is a promising biomarker to differentiate CPFE from IPF. In CPFE cases respiratory and functional parameters are worse than those of pure fibrosis cases. | |
dc.identifier.doi | 10.36141/svdld.v39i4.11344 | |
dc.identifier.issn | 1124-0490 | |
dc.identifier.issue | 4 | |
dc.identifier.uri | https://doi.org/10.36141/svdld.v39i4.11344 | |
dc.identifier.uri | https://hdl.handle.net/11452/44338 | |
dc.identifier.volume | 39 | |
dc.identifier.wos | 000911483000002 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Mattioli 1885 | |
dc.relation.journal | Sarcoidosis Vasculitis And Diffuse Lung Diseases | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Idiopathic pulmonary-fibrosis | |
dc.subject | Surfactant protein-a | |
dc.subject | Quality-of-life | |
dc.subject | Circulating kl-6 | |
dc.subject | Emphysema | |
dc.subject | Hypertension | |
dc.subject | Markers | |
dc.subject | Combined pulmonary fibrosis emphysema | |
dc.subject | Idiopathic pulmonary fibrosis | |
dc.subject | Krebs von den lungen-6 | |
dc.subject | Surfactant protein-a | |
dc.subject | Surfactant protein-d | |
dc.subject | Pulmonary function tests | |
dc.subject | Echocardiography | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Respiratory system | |
dc.title | Serum cancer from lung-6: Promising biomarker to differentiate cpfe from ipf | |
dc.type | Article | |
dspace.entity.type | Publication | |
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relation.isAuthorOfPublication.latestForDiscovery | 80df98cb-7a8e-4a6c-86c1-65dfe8f4e962 |
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