Publication:
Can early pregnancy decorin levels be a potential predictor for preterm birth?

dc.contributor.authorÖzgen, Gülten
dc.contributor.buuauthorÖzgen, Levent
dc.contributor.buuauthorÖZGEN, LEVENT
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Onkoloji Anabilim Dalı
dc.contributor.researcheridJFT-0660-2023
dc.date.accessioned2024-10-22T12:44:56Z
dc.date.available2024-10-22T12:44:56Z
dc.date.issued2022-11-01
dc.description.abstractObjective: This study investigates the role of maternal decorin levels measured in the early second trimester of pregnancy in detecting the potential for preterm birth in late pregnancy.Methods: The prospective, case-control study was carried out in tertiary university hospital from June to December 2021.Maternal serum samples were collected from 350 women aged 18-40 years with a singleton pregnancy during early second-trimester screening for aneuploidy, and stored at -80 degrees C. All participants were followed up until delivery and 25 patients diagnosed with preterm birth group and 40 full-term healthy women were included in the study.Results: The median maternal serum decorin level was 3.82 (1.15-12.37) ng/ml in the preterm birth (PTB) group and 4.63 (1.20-10.02) ng/ml in the control group, there was no statistically difference between the groups (p = 0.111). The mean gestational age was statistically significantly lower in the preterm birth group (33.1 +/- 2.7 weeks) than in the control (39 +/- 1.16 weeks) ( p <0.001). The mean fetal weight was statistically significantly lower in the preterm birth group (2023.8 +/- 477 g) than in the control group (3309.7 +/- 353 g) (p < 0.001).Conclusion: Early second-trimester serum levels of decorin alone may not be a sufficiently accurate biomarker as a biochemical model for the prediction of preterm birth in asymptomatic women.
dc.identifier.doi10.12669/pjms.38.8.6551
dc.identifier.issn1682-024X
dc.identifier.issue8
dc.identifier.urihttps://doi.org/10.12669/pjms.38.8.6551
dc.identifier.urihttps://hdl.handle.net/11452/46860
dc.identifier.volume38
dc.identifier.wos000867664200003
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherProfessional Medical Publications
dc.relation.journalPakistan Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiglycan
dc.subjectEpidemiology
dc.subjectHyaluronan
dc.subjectRisk
dc.subjectBiomarker
dc.subjectDecorin
dc.subjectPreterm birth
dc.subjectPreterm delivery
dc.subjectPremature rupture of membranes
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectMedicine, general & internal
dc.subjectGeneral & internal medicine
dc.titleCan early pregnancy decorin levels be a potential predictor for preterm birth?
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationdb9dc18a-0202-4326-b5e8-67fe857a12b7
relation.isAuthorOfPublication.latestForDiscoverydb9dc18a-0202-4326-b5e8-67fe857a12b7

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