Publication:
Effects of immunosuppressive drugs on COVID-19 severity in patients with autoimmune hepatitis

dc.contributor.authorEfe, Cumali
dc.contributor.authorLammert, Craig
dc.contributor.authorTaşcılar, Koray
dc.contributor.authorDhanasekaran, Renumathy
dc.contributor.authorEbik, Berat
dc.contributor.authorHiguera-de la Tijera, Fatima
dc.contributor.authorÇalışkan, Ali R.
dc.contributor.authorPeralta, Mirta
dc.contributor.authorGerussi, Alessio
dc.contributor.authorMassoumi, Hatef
dc.contributor.authorCatana, Andreea M.
dc.contributor.authorPurnak, Tuğrul
dc.contributor.authorRigamonti, Cristina
dc.contributor.authorAldana, Andres J. G.
dc.contributor.authorKhakoo, Nidah
dc.contributor.authorNazal, Leyla
dc.contributor.authorFrager, Shalom
dc.contributor.authorDemir, Nurhan
dc.contributor.authorIrak, Kader
dc.contributor.authorMelekoğlu-Ellik, Zeynep
dc.contributor.authorKaçmaz, Hüseyin
dc.contributor.authorBalaban, Yasemin
dc.contributor.authorAtay, Kadri
dc.contributor.authorEren, Fatih
dc.contributor.authorAlvares-da-Silva, Mario R.
dc.contributor.authorCristoferi, Laura
dc.contributor.authorUrzua, Alvaro
dc.contributor.authorEskazan, Tuğçe
dc.contributor.authorMagro, Bianca
dc.contributor.authorSnijders, Romee
dc.contributor.authorBarutcu, Sezgin
dc.contributor.authorLytvyak, Ellina
dc.contributor.authorZazueta, Godolfino M.
dc.contributor.authorDemirezer-Bolat, Aylin
dc.contributor.authorAydın, Mesut
dc.contributor.authorHeurgue-Berlot, Alexandra
dc.contributor.authorDe Martin, Eleonora
dc.contributor.authorEkin, Nazım
dc.contributor.authorYıldırım, Sümeyra
dc.contributor.authorYavuz, Ahmet
dc.contributor.authorBıyık, Murat
dc.contributor.authorNarro, Graciela C.
dc.contributor.authorKıyıcı, Murat
dc.contributor.authorAkyıldız, Murat
dc.contributor.authorKahramanoğlu-Aksoy, Evrim
dc.contributor.authorVincent, Maria
dc.contributor.authorCarr, Rotonya M.
dc.contributor.authorGünşar, Fulya
dc.contributor.authorReyes, Eira C.
dc.contributor.authorHarputluoğlu, Murat
dc.contributor.authorAloman, Costica
dc.contributor.authorGatselis, Nikolaos K.
dc.contributor.authorUstundağ, Yücel
dc.contributor.authorBrahm, Javier
dc.contributor.authorVargas, Nataly C. E.
dc.contributor.authorGüzelbulut, Fatih
dc.contributor.authorGarcia, Sandro R.
dc.contributor.authorAguirre, Jonathan
dc.contributor.authorAnders, Margarita
dc.contributor.authorRatusnu, Natalia
dc.contributor.authorHatemi, İbrahim
dc.contributor.authorMendizabal, Manuel
dc.contributor.authorFloreani, Annarosa
dc.contributor.authorFagiuoli, Stefano
dc.contributor.authorSilva, Marcelo
dc.contributor.authorIdılman, Ramazan
dc.contributor.authorSatapathy, Sanjaya K.
dc.contributor.authorSilveira, Marina
dc.contributor.authorDrenth, Joost P. H.
dc.contributor.authorDalekos, George N.
dc.contributor.authorAssis, David N.
dc.contributor.authorBjornsson, Einar
dc.contributor.authorBoyer, James L.
dc.contributor.authorYoshida, Eric M.
dc.contributor.authorInvernizzi, Pietro
dc.contributor.authorLevy, Cynthia
dc.contributor.authorMontano-Loza, Aldo J.
dc.contributor.authorSchiano, Thomas D.
dc.contributor.authorRidruejo, Ezequiel
dc.contributor.authorWahlin, Staffan
dc.contributor.buuauthorKIYICI, MURAT
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.
dc.contributor.researcheridFHW-0015-2022
dc.date.accessioned2024-06-14T07:15:31Z
dc.date.available2024-06-14T07:15:31Z
dc.date.issued2021-11-28
dc.description.abstractBackground We investigated associations between baseline use of immunosuppressive drugs and severity of Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis (AIH). Patients and methods Data of AIH patients with laboratory confirmed COVID-19 were retrospectively collected from 15 countries. The outcomes of AIH patients who were on immunosuppression at the time of COVID-19 were compared to patients who were not on AIH medication. The clinical courses of COVID-19 were classified as (i)-no hospitalization, (ii)-hospitalization without oxygen supplementation, (iii)-hospitalization with oxygen supplementation by nasal cannula or mask, (iv)-intensive care unit (ICU) admission with non-invasive mechanical ventilation, (v)-ICU admission with invasive mechanical ventilation or (vi)-death and analysed using ordinal logistic regression. Results We included 254 AIH patients (79.5%, female) with a median age of 50 (range, 17-85) years. At the onset of COVID-19, 234 patients (92.1%) were on treatment with glucocorticoids (n = 156), thiopurines (n = 151), mycophenolate mofetil (n = 22) or tacrolimus (n = 16), alone or in combinations. Overall, 94 (37%) patients were hospitalized and 18 (7.1%) patients died. Use of systemic glucocorticoids (adjusted odds ratio [aOR] 4.73, 95% CI 1.12-25.89) and thiopurines (aOR 4.78, 95% CI 1.33-23.50) for AIH was associated with worse COVID-19 severity, after adjusting for age-sex, comorbidities and presence of cirrhosis. Baseline treatment with mycophenolate mofetil (aOR 3.56, 95% CI 0.76-20.56) and tacrolimus (aOR 4.09, 95% CI 0.69-27.00) were also associated with more severe COVID-19 courses in a smaller subset of treated patients. Conclusion Baseline treatment with systemic glucocorticoids or thiopurines prior to the onset of COVID-19 was significantly associated with COVID-19 severity in patients with AIH.
dc.description.sponsorshipMinistry of Education, Universities and Research (MIUR)
dc.identifier.doi10.1111/liv.15121
dc.identifier.eissn1478-3231
dc.identifier.endpage614
dc.identifier.issn1478-3223
dc.identifier.issue3
dc.identifier.startpage607
dc.identifier.urihttps://doi.org/10.1111/liv.15121
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/liv.15121
dc.identifier.urihttps://hdl.handle.net/11452/42192
dc.identifier.volume42
dc.identifier.wos000729531700001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWiley
dc.relation.journalLiver International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLiver-transplant recipients
dc.subjectSars-CoV-2 infection
dc.subjectAutoimmunity
dc.subjectAzathioprine
dc.subjectBudesonide
dc.subjectLiver transplantation
dc.subjectMercaptopurine
dc.subjectSars-CoV-2
dc.subjectGastroenterology & hepatology
dc.titleEffects of immunosuppressive drugs on COVID-19 severity in patients with autoimmune hepatitis
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationb364b52b-c416-4987-b080-93f6f81ecb3e
relation.isAuthorOfPublication.latestForDiscoveryb364b52b-c416-4987-b080-93f6f81ecb3e

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