Publication: Hemostatic effect of a chitosan linear polymer (Celox (R)) in a severe femoral artery bleeding rat model under hypothermia or warfarin therapy
dc.contributor.buuauthor | Köksal, Özlem | |
dc.contributor.buuauthor | Özdemir, Fatma | |
dc.contributor.buuauthor | Çametöz, Betül | |
dc.contributor.buuauthor | İşbil Büyükcoşkun, Naciye | |
dc.contributor.buuauthor | Sığırlı, Deniz | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Acil Tıp Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı. | tr_TR |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/İstatistik Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0003-2271-5659 | tr_TR |
dc.contributor.researcherid | AAK-8332-2020 | tr_TR |
dc.contributor.researcherid | AAH-1692-2021 | tr_TR |
dc.contributor.researcherid | AAA-7472-2021 | tr_TR |
dc.contributor.scopusid | 23389880200 | tr_TR |
dc.contributor.scopusid | 7006765911 | tr_TR |
dc.contributor.scopusid | 57215331517 | tr_TR |
dc.contributor.scopusid | 55665951400 | tr_TR |
dc.contributor.scopusid | 24482063400 | tr_TR |
dc.date.accessioned | 2021-12-15T11:06:10Z | |
dc.date.available | 2021-12-15T11:06:10Z | |
dc.date.issued | 2011 | |
dc.description.abstract | In this study, the hemostatic efficacy of Celox (R) in rats under hypothermia or warfarin treatment was investigated. A total of forty-eight Sprague-Dawley female rats weighing 200-350 g were used in the study. Six experimental study groups were designed, as follows: Group 1: Normothermia + compression; Group 2: normothermia + Celox (R); Group 3: hypothermia + compression; Group 4: hypothermia + Celox (R); Group 5: normothermia + warfarin + compression; and Group 6: normothermia + warfarin + Celox (R). Celox (R) provided effective hemorrhage control in all three tested groups. There was a statistically significant difference between compression and Celox (R) implementation in all groups in terms of hemostasis (p-values for the normothermia, hypothermia and warfarin groups were p < 0.05, p < 0.01 and p < 0.01, respectively). Furthermore, the compression numbers were significantly lower in all of the groups that received Celox (R) than in those in which compression alone was applied (p-values for the normothermia, hypothermia and warfarin groups were p < 0.01, p < 0.01 and p < 0.001, respectively). Celox (R) provides effective hemorrhage control under conditions of normothermia, hypothermia and use of the oral anticoagulant agent warfarin. | en_US |
dc.identifier.citation | Köksal, Ö. vd. (2011). "Hemostatic effect of a chitosan linear polymer (Celox (R)) in a severe femoral artery bleeding rat model under hypothermia or warfarin therapy". Ulusal Travma ve Acil Cerrahi Dergisi, 17(3), 199-204. | tr_TR |
dc.identifier.endpage | 204 | tr_TR |
dc.identifier.issn | 1306-696X | |
dc.identifier.issue | 3 | tr_TR |
dc.identifier.pubmed | 21935795 | tr_TR |
dc.identifier.scopus | 2-s2.0-79959807646 | tr_TR |
dc.identifier.startpage | 199 | tr_TR |
dc.identifier.uri | https://doi.org/10.5505/tjtes.2011.88155 | |
dc.identifier.uri | https://jag.journalagent.com/travma/pdfs/UTD-88155-RESEARCH_ARTICLE-KOKSAL.pdf | |
dc.identifier.uri | http://hdl.handle.net/11452/23287 | |
dc.identifier.volume | 17 | tr_TR |
dc.identifier.wos | 000292134600002 | |
dc.indexed.pubmed | Pubmed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.trdizin | TrDizin | tr_TR |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Ulusal Travma ve Acil Cerrahi Derneği | tr_TR |
dc.relation.bap | BAP | tr_TR |
dc.relation.journal | Ulusal Travma ve Acil Cerrahi Dergisi | tr_TR |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Emergency medicine | en_US |
dc.subject | Bleeding control | en_US |
dc.subject | Celox (R) | en_US |
dc.subject | Hypothermia | en_US |
dc.subject | Warfarin | en_US |
dc.subject | N-acetyl glucosamine | en_US |
dc.subject | Lethal groin injury | en_US |
dc.subject | Lingual hemostasis | en_US |
dc.subject | Swine model | en_US |
dc.subject | Topical hemostats | en_US |
dc.subject | Animal-model | en_US |
dc.subject | Hemorrhage | en_US |
dc.subject | Trauma | en_US |
dc.subject | Survival | en_US |
dc.subject | Agents | en_US |
dc.subject.emtree | Celox | en_US |
dc.subject.emtree | Chitosan derivative | en_US |
dc.subject.emtree | Chitosan linear polymer | en_US |
dc.subject.emtree | Hemostatic agent | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.emtree | Warfarin | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Bleeding | en_US |
dc.subject.emtree | Body temperature | en_US |
dc.subject.emtree | Compression therapy | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Dark agouti rat | en_US |
dc.subject.emtree | Drug efficacy | en_US |
dc.subject.emtree | Experimental study | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Femoral artery bleeding | en_US |
dc.subject.emtree | Hemostasis | en_US |
dc.subject.emtree | Induced hypothermia | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Tracheostomy | en_US |
dc.subject.scopus | Hemostatics; Gauze; Celox | en_US |
dc.subject.wos | Emergency medicine | en_US |
dc.title | Hemostatic effect of a chitosan linear polymer (Celox (R)) in a severe femoral artery bleeding rat model under hypothermia or warfarin therapy | en_US |
dc.type | Article | |
dc.wos.quartile | Q4 | en_US |
dspace.entity.type | Publication |
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