Publication:
Hemostatic effect of a chitosan linear polymer (Celox (R)) in a severe femoral artery bleeding rat model under hypothermia or warfarin therapy

dc.contributor.buuauthorKöksal, Özlem
dc.contributor.buuauthorÖzdemir, Fatma
dc.contributor.buuauthorÇametöz, Betül
dc.contributor.buuauthorİşbil Büyükcoşkun, Naciye
dc.contributor.buuauthorSığırlı, Deniz
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Acil Tıp Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İstatistik Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-2271-5659tr_TR
dc.contributor.researcheridAAK-8332-2020tr_TR
dc.contributor.researcheridAAH-1692-2021tr_TR
dc.contributor.researcheridAAA-7472-2021tr_TR
dc.contributor.scopusid23389880200tr_TR
dc.contributor.scopusid7006765911tr_TR
dc.contributor.scopusid57215331517tr_TR
dc.contributor.scopusid55665951400tr_TR
dc.contributor.scopusid24482063400tr_TR
dc.date.accessioned2021-12-15T11:06:10Z
dc.date.available2021-12-15T11:06:10Z
dc.date.issued2011
dc.description.abstractIn this study, the hemostatic efficacy of Celox (R) in rats under hypothermia or warfarin treatment was investigated. A total of forty-eight Sprague-Dawley female rats weighing 200-350 g were used in the study. Six experimental study groups were designed, as follows: Group 1: Normothermia + compression; Group 2: normothermia + Celox (R); Group 3: hypothermia + compression; Group 4: hypothermia + Celox (R); Group 5: normothermia + warfarin + compression; and Group 6: normothermia + warfarin + Celox (R). Celox (R) provided effective hemorrhage control in all three tested groups. There was a statistically significant difference between compression and Celox (R) implementation in all groups in terms of hemostasis (p-values for the normothermia, hypothermia and warfarin groups were p < 0.05, p < 0.01 and p < 0.01, respectively). Furthermore, the compression numbers were significantly lower in all of the groups that received Celox (R) than in those in which compression alone was applied (p-values for the normothermia, hypothermia and warfarin groups were p < 0.01, p < 0.01 and p < 0.001, respectively). Celox (R) provides effective hemorrhage control under conditions of normothermia, hypothermia and use of the oral anticoagulant agent warfarin.en_US
dc.identifier.citationKöksal, Ö. vd. (2011). "Hemostatic effect of a chitosan linear polymer (Celox (R)) in a severe femoral artery bleeding rat model under hypothermia or warfarin therapy". Ulusal Travma ve Acil Cerrahi Dergisi, 17(3), 199-204.tr_TR
dc.identifier.endpage204tr_TR
dc.identifier.issn1306-696X
dc.identifier.issue3tr_TR
dc.identifier.pubmed21935795tr_TR
dc.identifier.scopus2-s2.0-79959807646tr_TR
dc.identifier.startpage199tr_TR
dc.identifier.urihttps://doi.org/10.5505/tjtes.2011.88155
dc.identifier.urihttps://jag.journalagent.com/travma/pdfs/UTD-88155-RESEARCH_ARTICLE-KOKSAL.pdf
dc.identifier.urihttp://hdl.handle.net/11452/23287
dc.identifier.volume17tr_TR
dc.identifier.wos000292134600002
dc.indexed.pubmedPubmeden_US
dc.indexed.scopusScopusen_US
dc.indexed.trdizinTrDizintr_TR
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherUlusal Travma ve Acil Cerrahi Derneğitr_TR
dc.relation.bapBAPtr_TR
dc.relation.journalUlusal Travma ve Acil Cerrahi Dergisitr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEmergency medicineen_US
dc.subjectBleeding controlen_US
dc.subjectCelox (R)en_US
dc.subjectHypothermiaen_US
dc.subjectWarfarinen_US
dc.subjectN-acetyl glucosamineen_US
dc.subjectLethal groin injuryen_US
dc.subjectLingual hemostasisen_US
dc.subjectSwine modelen_US
dc.subjectTopical hemostatsen_US
dc.subjectAnimal-modelen_US
dc.subjectHemorrhageen_US
dc.subjectTraumaen_US
dc.subjectSurvivalen_US
dc.subjectAgentsen_US
dc.subject.emtreeCeloxen_US
dc.subject.emtreeChitosan derivativeen_US
dc.subject.emtreeChitosan linear polymeren_US
dc.subject.emtreeHemostatic agenten_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeWarfarinen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBleedingen_US
dc.subject.emtreeBody temperatureen_US
dc.subject.emtreeCompression therapyen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDark agouti raten_US
dc.subject.emtreeDrug efficacyen_US
dc.subject.emtreeExperimental studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFemoral artery bleedingen_US
dc.subject.emtreeHemostasisen_US
dc.subject.emtreeInduced hypothermiaen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeTracheostomyen_US
dc.subject.scopusHemostatics; Gauze; Celoxen_US
dc.subject.wosEmergency medicineen_US
dc.titleHemostatic effect of a chitosan linear polymer (Celox (R)) in a severe femoral artery bleeding rat model under hypothermia or warfarin therapyen_US
dc.typeArticle
dc.wos.quartileQ4en_US
dspace.entity.typePublication

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