Publication:
Biomacromolecular interactions and radical scavenging activities of one-dimensional (1D) copper(II) glycinate coordination polymer

dc.contributor.authorİnci, Duygu
dc.contributor.authorAydın, Rahmiye
dc.contributor.authorZorlu, Yunus
dc.contributor.buuauthorAYDIN, RAHMİYE
dc.contributor.departmentBursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü
dc.contributor.orcid0000-0003-4944-0181
dc.contributor.researcheridAAH-8936-2021
dc.date.accessioned2024-06-28T10:25:12Z
dc.date.available2024-06-28T10:25:12Z
dc.date.issued2021-05-18
dc.description.abstractOne-dimensional (1D) copper(II) glycinate coordination polymer {[Cu(gly)(2)(H2O)](n); (gly: glycine)} has been synthesized and characterized by CHN analysis, ESI-MS, FTIR and single-crystal X-ray diffraction techniques. Interaction of the complex with biomacromolecules {calf thymus DNA (CT-DNA) and bovine serum albumin (BSA)} has been investigated by electronic absorption and fluorescence spectroscopy methods. The experimental outcomes indicate that the complex binds to CT-DNA by means of a moderate intercalation mode. Furthermore, the fluorescence quenching mechanism between the complex and BSA is a static quenching process. The Stern-Volmer constants, binding constants, binding sites and the corresponding thermodynamic parameters (Delta G, Delta H, Delta S) of BSA + the complex systems were determined at different temperatures. The binding distance between the complex and BSA was calculated according to Forster non-radiation energy transfer theory (FRET). The effect of the complex on the conformation of BSA was also examined using synchronous, two-dimensional (2D) and three-dimensional (3D) fluorescence spectroscopy. Radical scavenging activity of the complex was determined in terms of IC50, using the DPPH and H2O2 method. In biomacromolecules interactions and radical activity studies, the complex was found to give good results.
dc.identifier.doi10.1007/s13738-021-02249-1
dc.identifier.eissn1735-2428
dc.identifier.endpage3030
dc.identifier.issn1735-207X
dc.identifier.issue11
dc.identifier.startpage3017
dc.identifier.urihttps://doi.org/10.1007/s13738-021-02249-1
dc.identifier.urihttps://hdl.handle.net/11452/42576
dc.identifier.urihttps://link.springer.com/article/10.1007/s13738-021-02249-1
dc.identifier.volume18
dc.identifier.wos000651660800001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer
dc.relation.bapBYGP-2018/1
dc.relation.journalJournal of The Iranian Chemical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBovine serum-albumin
dc.subjectIn-vitro dna
dc.subjectAntioxidant activity
dc.subjectMolecular docking
dc.subjectAmino-acid
dc.subjectCrystal-structure
dc.subjectBinding interaction
dc.subjectLigands synthesis
dc.subjectEthidium-bromide
dc.subjectComplexes
dc.subjectCopper(ii)
dc.subjectGlycine
dc.subjectBiomacromolecular interactions
dc.subjectRadical scavenging activity
dc.subjectScience & technology
dc.subjectPhysical sciences
dc.subjectChemistry, multidisciplinary
dc.subjectChemistry
dc.titleBiomacromolecular interactions and radical scavenging activities of one-dimensional (1D) copper(II) glycinate coordination polymer
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication664dd2c7-f9b5-4cfd-ad90-163ae2c8685f
relation.isAuthorOfPublication.latestForDiscovery664dd2c7-f9b5-4cfd-ad90-163ae2c8685f

Files

Collections