Publication: Vascular functional effect mechanisms of elabela in rat thoracic aorta
dc.contributor.buuauthor | Şahintürk, Serdar | |
dc.contributor.buuauthor | ŞAHİNTÜRK, SERDAR | |
dc.contributor.buuauthor | ÖZYENER, FADIL | |
dc.contributor.buuauthor | Demirel, Sadettin | |
dc.contributor.buuauthor | İŞBİL, NACİYE | |
dc.contributor.buuauthor | DEMİREL, SADETTİN | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı. | |
dc.contributor.researcherid | AAH-3460-2021 | |
dc.contributor.researcherid | AAH-1641-2021 | |
dc.contributor.researcherid | ACQ-9887-2022 | |
dc.date.accessioned | 2024-11-06T11:29:11Z | |
dc.date.available | 2024-11-06T11:29:11Z | |
dc.date.issued | 2022-08-01 | |
dc.description.abstract | Background: Elabela is a recently discovered peptide hormone. The present study aims to investigate the vasorelaxant effect mechanisms of elabela in the rat thoracic aorta.Methods: The vascular rings obtained from the thoracic aortas of the male Wistar albino rats were placed in the isolated tissue bath system. Resting tension was set to 1 gram. After the equilibration period, the vessel rings were contracted with phenylephrine or potassium chloride. Once a stable contraction was achieved, elabela-32 was applied cumulatively (10(-9)-10(-6) molar) to the vascular rings. The experimental protocol was repeated in the presence of specific signaling pathway inhibitors or potassium channel blockers to determine the effect mechanisms of elabela.Results: Elabela showed a significant vasorelaxant effect in a concentration-dependent manner (P < 0.001). The vasorelaxant effect level of elabela was significantly reduced by the apelin receptor antagonist F13A, cyclooxygenase inhibitor indomethacin, adenosine monophosphate-activated protein kinase inhibitor dorsomorphin, protein kinase C inhibitor bisindolmaleimide, large-conductance calcium-activated potassium channel blocker iberiotoxin, and intermediate-conductance calcium-activated potassium channel blocker TRAM-34 (P < 0.001). However, the vasorelaxant effect level of elabela was not significantly affected by the endothelial nitric oxide synthase inhibitor nitro-L-arginine methyl ester and mitogen-activated protein kinase inhibitor U0126.Conclusions: Elabela exhibits a prominent vasodilator effect in rat thoracic aorta. Apelin receptor, prostanoids, adenosine monophosphate-activated protein kinase, protein kinase C, and calcium-activated potassium channels are involved in the vasorelaxant effect mechanisms of elabela. | |
dc.identifier.doi | 10.1016/j.avsg.2022.04.033 | |
dc.identifier.endpage | 397 | |
dc.identifier.issn | 0890-5096 | |
dc.identifier.startpage | 381 | |
dc.identifier.uri | https://doi.org/10.1016/j.avsg.2022.04.033 | |
dc.identifier.uri | https://hdl.handle.net/11452/47486 | |
dc.identifier.volume | 84 | |
dc.identifier.wos | 000855847700041 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Elsevier Science Inc | |
dc.relation.journal | Annals Of Vascular Surgery | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.relation.tubitak | 119S971 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Activated protein-kinase | |
dc.subject | Resistance arteries | |
dc.subject | Blood-pressure | |
dc.subject | Angiotensin-ii | |
dc.subject | Heart-failure | |
dc.subject | Apelin | |
dc.subject | Preeclampsia | |
dc.subject | Channels | |
dc.subject | Disease | |
dc.subject | Vasoconstriction | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Surgery | |
dc.subject | Peripheral vascular disease | |
dc.subject | Cardiovascular system & cardiology | |
dc.title | Vascular functional effect mechanisms of elabela in rat thoracic aorta | |
dc.type | Article | |
dspace.entity.type | Publication | |
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relation.isAuthorOfPublication.latestForDiscovery | 25bede72-9942-49c8-b45d-1e94eaf9062d |