Publication:
Effects of vitamin C supplementation on oxidative stress and serum paraoxonase/arylesterase activities in patients on long-term hemodialysis

dc.contributor.authorSarandöl, Emre
dc.contributor.authorErdinç, Selda
dc.contributor.authorŞenol, Emel
dc.contributor.authorErsoy, Alparslan
dc.contributor.authorSürmen-Gura, Esma
dc.contributor.buuauthorSARANDÖL, EMRE
dc.contributor.buuauthorErdinç, Selda
dc.contributor.buuauthorŞenol, Emel
dc.contributor.buuauthorERSOY, ALPARSLAN
dc.contributor.buuauthorSürmen-Gura, Esma
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.
dc.contributor.orcid0000-0001-7377-9682
dc.contributor.researcheridJVN-0414-2024
dc.contributor.researcheridAAG-7327-2021
dc.contributor.researcheridJKC-3379-2023
dc.contributor.researcheridDSA-1108-2022
dc.contributor.researcheridCPX-5894-2022
dc.date.accessioned2024-10-24T09:04:32Z
dc.date.available2024-10-24T09:04:32Z
dc.date.issued2023-09-01
dc.description.abstractBackground: Oxidative stress increases oxidizability of apolipoprotein-B containing lipoproteins and decreases paraoxonase (PON) activity in hemodialysis (HD) patients and plays an important part in the development of atherosclerotic cardiovascular diseases. In HD patients, plasma ascorbic acid (AA) levels are decreased either due to the loss by hemodialysis membranes or due to malnutrition and contribute to the imbalance of antioxidant defense mechanisms. We hypothesized that long-term ascorbic acid (AA) supplementation recovers oxidizability of lipoproteins in HD patients by reinforcing PON activity. Methods: Twenty-nine adult patients were treated with 100 mg and 500 mg AA at the end of each HD session thrice a week for two consecutive 16 weeks-periods, respectively. Blood samples were obtained before the first HD session and prior to the first HD sessions following the 100 mg AA-supplemented and the 500 mg AA-supplemented periods. Results: PON activities were significantly increased after 100 mg (p < 0.05) and 500 mg AA (p < 0.001) supplementation periods compared to the basal level. Apo-B lipoprotein oxidizability (Delta-MDA) was significantly decreased after 500 mg AA supplementation compared to both basal (p < 0.05) and 100 mg AA supplementation periods (p < 0.05). Plasma AA concentrations were negatively correlated with Delta-MDA levels (R = -0.327; p < 0.01). Conclusion: Our results suggest that long-term parenteral 500 mg AA supplementation improves PON activity alleviating apo B-containing lipoproteins oxidizability in HD patients. (c) 2021 Sociedad Espanola de Nefrolog ' ia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/).
dc.identifier.doi10.1016/j.nefroe.2022.11.024
dc.identifier.endpage359
dc.identifier.issn0211-6995
dc.identifier.issue3
dc.identifier.startpage351
dc.identifier.urihttps://doi.org/10.1016/j.nefroe.2022.11.024
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S201325142200150X?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11452/47004
dc.identifier.volume43
dc.identifier.wos001068572500010
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSoc Espanola Nefrologia Dr Rafael Matesanz
dc.relation.bapT-2006/14
dc.relation.journalNefrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLow-density-lipoprotein
dc.subjectRenal-disease patients
dc.subjectB-containing lipoproteins
dc.subjectLipid-peroxidation
dc.subjectCitrate dialysate
dc.subjectAscorbic-acid
dc.subjectCholesterol
dc.subjectPlasma
dc.subjectAtherosclerosis
dc.subjectInhibition
dc.subjectHemodialysis
dc.subjectOxidative stress
dc.subjectParaoxonase
dc.subjectAscorbic acid
dc.subjectApo-b oxidizability
dc.subjectUrology & nephrology
dc.titleEffects of vitamin C supplementation on oxidative stress and serum paraoxonase/arylesterase activities in patients on long-term hemodialysis
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication9529fb52-20cd-4fb3-9767-19121683aa62
relation.isAuthorOfPublication3b0ea0d7-f953-4c53-9e92-e260b04f90b4
relation.isAuthorOfPublication.latestForDiscovery9529fb52-20cd-4fb3-9767-19121683aa62

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