Publication:
Pregnancy and kidney transplantation: A single-center experience

dc.contributor.authorAyar, Yavuz
dc.contributor.authorSayılar, Emel Işıktaş
dc.contributor.buuauthorDemir, Bilge Cetinkaya
dc.contributor.buuauthorÇETİNKAYA DEMİR, BİLGE
dc.contributor.buuauthorERSOY, ALPARSLAN
dc.contributor.buuauthorOCAKOĞLU, GÖKHAN
dc.contributor.buuauthorYILDIZ, ABDULMECİT
dc.contributor.buuauthorORUÇ, AYŞEGÜL
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Jinekoloji ve Doğum Anabilim Dalı.
dc.contributor.orcid0000-0003-4607-9220
dc.contributor.orcid0000-0002-1114-6051
dc.contributor.orcid0000-0002-0342-9692
dc.contributor.orcid0000-0001-6845-9991
dc.contributor.researcheridAAH-5180-2021
dc.contributor.researcheridAAH-4002-2021
dc.date.accessioned2024-11-07T11:39:27Z
dc.date.available2024-11-07T11:39:27Z
dc.date.issued2022-07-01
dc.description.abstractObjective: The possibility of pregnancy increases with kidney transplantation in patients with chronic kidney disease. However, graft dysfunction, risk of fetal growth retardation, and fetal anomaly should be monitored closely. In this study, renal and obstetric outcomes were analyzed in pregnant kidney recipients who were followed in our center.Methods: We analyzed 140 reproductive-aged patients who underwent renal transplantation between January 2009 and May 2015, and clinical and laboratory data were evaluated retrospectively.Results: Twenty-four patients became pregnant (17.1%). In pregnant group, median age was significantly lower than nonpregnant group (P =.014). The median age of pregnant group at the time of transplantation was also significantly lower than non-pregnant patients (P <.001). The rate of pregnant patients was 66.7% in 18-25 year age group (P =.008). The rate of urinary tract infection in non-pregnant group was higher than pregnant group (P =.03). Live birth rates were 83.3% and 45.8% of those whose birth weight was higher than 2500 g. The increased level of daily urinary proteinuria and the time from diagnosis of renal failure to transplantation had significant effect on pregnancy (odds ratio = 13.81;95% CI: 2.06-92.45; P =.007 and odds ratio = 3.25;95% CI: 1.11-9.48; P =.031, respectively). Low serum creatinine level had significant protective effect (odds ratio = 0.001; 95% CI: 0-0.30, P =.018). The patients in 18-25 age group were 48.39 times more eligible for pregnancy compared to those in >35 age group (odds ratio = 48.39; 95% CI: 1.26-1860.72; P =.037). Rejection episodes were observed in 1 of pregnant women and 11 of non-pregnant women (P >.05).Conclusion: Pregnancy is possible in kidney transplant recipients of reproductive age. Calcineurin inhibitors and azathioprine seem to be safe. Maternal age, low-serum creatinine, and urinary proteinuria affect pregnancy. The close monitoring of renal function and fetal parameters is very important.
dc.identifier.doi10.5152/turkjnephrol.2022.21119
dc.identifier.endpage249
dc.identifier.issue3
dc.identifier.startpage244
dc.identifier.urihttps://doi.org/10.5152/turkjnephrol.2022.21119
dc.identifier.urihttps://hdl.handle.net/11452/47573
dc.identifier.volume31
dc.identifier.wos000838716100009
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherAves
dc.relation.journalTurkish Journal Of Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRecipients
dc.subjectRenal transplantation
dc.subjectPregnancy
dc.subjectFetal complication
dc.subjectImmunosuppression
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectUrology & nephrology
dc.titlePregnancy and kidney transplantation: A single-center experience
dc.typeArticle
dspace.entity.typePublication
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