Publication: Follow-up of human adenovirus viral load in pediatric hematopoietic stem cell transplant recipients
dc.contributor.author | Peker, Bilal Olcay | |
dc.contributor.author | Kıntrup, Gülen Tüysüz | |
dc.contributor.author | Sağlık, İmran | |
dc.contributor.author | Sarinoğlu, Rabia Can | |
dc.contributor.author | Güler, Elif | |
dc.contributor.author | Mutlu, Derya | |
dc.contributor.author | Küpesiz, Osman Alphan | |
dc.contributor.author | Çolak, Dilek | |
dc.contributor.buuauthor | SAĞLIK, İMRAN | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Tıbbi Mikrobiyoloji Ana Bilim Dalı | |
dc.contributor.orcid | 0000-0003-0864-4989 | |
dc.contributor.researcherid | A-4970-2019 | |
dc.contributor.researcherid | GCM-3391-2022 | |
dc.date.accessioned | 2024-06-27T11:03:33Z | |
dc.date.available | 2024-06-27T11:03:33Z | |
dc.date.issued | 2021-01-16 | |
dc.description.abstract | Background: The spectrum of human adenovirus (HAdV)-related disease is broad, and the virus acts on many organs and systems in hematopoietic stem cell transplantation (HSCT) recipients. We aimed to evaluate the effect of HAdV-DNA positivity with clinical and laboratory findings 4 months after HSCT.Methods and results: We retrospectively investigated HAdV-DNA in 153 HSCT recipients (<= 18 years) by quantitative real-time polymerase chain reaction (RealStar; Altona Diagnostics). The results of samples from January 2014 to December 2017 are included. HAdV-DNA was positive for at least one sample type in 50 (32.67%) patients. HAdV-DNA positivity rate was 8.92% (N: 145/1625), 40.25% (N: 64/159), and 25% (N: 2/8) for plasma, stool, and urine samples, respectively. HAdV-DNA was positive in the plasma of 38 (24.83%) patients at a median 16 (range: 1-58 days) days after HSCT. The mortality rate was 23.68% and 6.95% in plasma HAdV-positive and HAdV-negative patients (p = .014). Moreover, HAdV-DNA positivity had an impact on overall survival for allogeneic-HSCT (p = .013), with the cumulative effect including graft-versus-host disease state in multivariate analysis (p = .014).Conclusions: Plasma HAdV-DNA positivity is a potential influencer that decreases survival in the early post-transplant period. Due to the high mortality rates, close monitoring is required of HAdV infections after HSCT with sensitive methods, especially at the early stage. | |
dc.identifier.doi | 10.1111/ctr.14209 | |
dc.identifier.eissn | 1399-0012 | |
dc.identifier.issn | 0902-0063 | |
dc.identifier.issue | 3 | |
dc.identifier.uri | https://doi.org/10.1111/ctr.14209 | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1111/ctr.14209 | |
dc.identifier.uri | https://hdl.handle.net/11452/42518 | |
dc.identifier.volume | 35 | |
dc.identifier.wos | 000607910900001 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.relation.journal | Clinical Transplantation | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Risk-factors | |
dc.subject | Infection | |
dc.subject | Diagnosis | |
dc.subject | Cytomegalovirus | |
dc.subject | Reconstitution | |
dc.subject | Virus | |
dc.subject | Hematopoietic stem cell transplantation | |
dc.subject | Human adenovirus | |
dc.subject | Quantitative polymerase chain reaction | |
dc.subject | Survival | |
dc.subject | Surgery | |
dc.subject | Transplantation | |
dc.title | Follow-up of human adenovirus viral load in pediatric hematopoietic stem cell transplant recipients | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Tıbbi Mikrobiyoloji Ana Bilim Dalı | |
relation.isAuthorOfPublication | aab7d5dd-72a4-4f3a-a677-1fdf3e13cadc | |
relation.isAuthorOfPublication.latestForDiscovery | aab7d5dd-72a4-4f3a-a677-1fdf3e13cadc |