Publication:
Effects of repeated intravenous doses of tranexamic acid on closed tibial fracture healing: Experimental study based on the rat model

dc.contributor.authorDoğan, İbrahim
dc.contributor.authorBirişik, Fevzi
dc.contributor.authorKalyenci, Ahmet Sinan
dc.contributor.authorBozkurt, Erol Rüstü
dc.contributor.authorÖztürkmen, Yusuf
dc.contributor.buuauthorBilgin, Yücel
dc.contributor.buuauthorBİLGİN, YÜCEL
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentOrtopedi ve Travmatoloji Ana Bilim Dalı
dc.date.accessioned2024-09-10T11:57:11Z
dc.date.available2024-09-10T11:57:11Z
dc.date.issued2023-09-01
dc.description.abstractObjective: The aim of this study was to assess the effects of tranexamic acid on fracture healing in the rat tibia closed fracture model.Methods: Sixty-four male Sprague-Dawley rats were included in this study, where closed fracture and intramedullary nailing were performed on their right tibial diaphyses. They were divided into 2 main groups, the experimental group, which was given weekly tranexamic acid injections, and the control group, which received no additional treatment. Eight rats from each group were sacrificed and evaluated for fracture healing at the first experimental group and control group, second experimental group and control group, third experimental group and control group, and fourth experimental group and control group weeks. Fracture healing was radiologically assessed according to the "Spencer Index" and "Lane and Sandhu Scoring System," and histologically evaluated according to the scoring system devised by Huo et al.Results: According to the Spencer Index, the mean union score was statistically significantly higher in the E3 group than in the third con-trol group (P = .014). Furthermore, the mean union score was statistically significantly higher in the fourth experimental group compared to the fourth control group (P = .047). According to the Lane and Sandhu Scoring System, only the mean union scores of the E3-4 groups were statistically significantly higher than the mean union scores of the C3-4 groups (P = .048). There was no histological difference between groups in terms of union, according to the criteria defined by Huo et al (P > .05).Conclusion: This study showed us that repeated intravenous administrations of tranexamic acid had no negative effect on fracture heal-ing in the rat tibia fracture model. Although tranexamic acid demonstrated better radiological healing in the late period, it had no effect on histological union.
dc.identifier.doi10.5152/j.aott.2023.22132
dc.identifier.issn1017-995X
dc.identifier.issue5
dc.identifier.urihttps://doi.org/10.5152/j.aott.2023.22132
dc.identifier.urihttps://hdl.handle.net/11452/44501
dc.identifier.volume57
dc.identifier.wos001127628500014
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherTurkish Assoc Orthopaedics Traumatology
dc.relation.journalActa Orthopaedica Et Traumatologica Turcica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTranexamic acid
dc.subjectClosed fracture
dc.subjectRat model
dc.subjectFracture healing
dc.subjectIntramedullary nailing
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectOrthopedics
dc.titleEffects of repeated intravenous doses of tranexamic acid on closed tibial fracture healing: Experimental study based on the rat model
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Ortopedi ve Travmatoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Ortopedi ve Travmatoloji Ana Bilim Dalı
relation.isAuthorOfPublication6c76eee8-6a44-4d69-a10c-613e41eaf796
relation.isAuthorOfPublication.latestForDiscovery6c76eee8-6a44-4d69-a10c-613e41eaf796

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