Publication:
Assessment of neurodegeneration by optical coherence tomography and mini-mental test in parkinson's disease

dc.contributor.authorYıldız, Demet
dc.contributor.authorPekel, Nilufer Büyükkoyuncu
dc.contributor.authorYener, Neslihan Parmak
dc.contributor.authorSeferoğlu, Meral
dc.contributor.authorGüneş, Aygül
dc.contributor.buuauthorSığırlı, Deniz
dc.contributor.buuauthorSIĞIRLI, DENİZ
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
dc.contributor.researcheridAAA-7472-2021
dc.date.accessioned2024-07-12T12:44:08Z
dc.date.available2024-07-12T12:44:08Z
dc.date.issued2019-04-01
dc.description.abstractBackground: Parkinson's disease is a neurodegenerative disease. Cognitive disorders and retinal degeneration may occur during the early stages of the disease. Retinal degeneration and cognitive findings can be assessed easily with optical coherence tomography and mini-mental test, respectively. Materials and Methods: Twenty-two patients who are being followed-up with Parkinson's disease and 22 healthy controls have been included in the study. The Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn-Yahr staging of the patients have been conducted at the time of admission. Retinal nerve fiber layer analysis and ganglion cell thickness (ganglion cell complexes [GCCs]) were evaluated through optical coherence tomography (OCT). And at the same time, we aimed to compare the stage of the disease, the UPDRS score and the duration of the disease with OCT and cognitive functions by mini-mental test. Results: Mini-mental test total score value (P = 0.025) and language value (P = 0.021) were lower in the patient group compared to the control group. In patients, there is a reverse significant correlation between UPDRS-T and GCC-left-superior (r = -0.495; P = 0.026), GCC-left-inferior (r = -0.517; P = 0.019), and GCC-left-to (r = -0.508; P = 0.022). There is a significant parallel relation between recall and RFNL-right-mean (r = 0.626; P = 0.039). Conclusion: Our findings indicate that the neurodegeneration continues multisystemically and neurodegeneration increases simultaneously with the disease. OCT, which is a noninvasive method, can be used as an indicator of neurodegeneration in patients with P arkinson's disease.
dc.identifier.doi10.4103/aian.AIAN_424_17
dc.identifier.endpage+
dc.identifier.issn0972-2327
dc.identifier.issue2
dc.identifier.startpage212
dc.identifier.urihttps://doi.org/10.4103/aian.AIAN_424_17
dc.identifier.urihttps://hdl.handle.net/11452/43266
dc.identifier.volume22
dc.identifier.wos000464167900016
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.journalAnnals Of Indian Academy Of Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectVisual dysfunction
dc.subjectSeverity
dc.subjectChoroidal thickness
dc.subjectOptical coherence tomography
dc.subjectParkinson's disease
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectClinical neurology
dc.subjectNeurosciences & neurology
dc.titleAssessment of neurodegeneration by optical coherence tomography and mini-mental test in parkinson's disease
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationf8b7b771-12ea-4f9a-889d-25079d8c862d
relation.isAuthorOfPublication.latestForDiscoveryf8b7b771-12ea-4f9a-889d-25079d8c862d

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