Publication:
Long-term results of splenectomy in transfusion-dependent thalassemia

dc.contributor.authorÖzdemir, Gül N.
dc.contributor.authorAyçiçek, Ali
dc.contributor.buuauthorAkça, Tuğberk
dc.contributor.buuauthorAKÇA, TUĞBERK
dc.contributor.buuauthorÖzkaya, Güven
dc.contributor.buuauthorÖZKAYA, GÜVEN
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentÇocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.contributor.orcid0000-0002-3204-4353
dc.contributor.orcid0000-0003-0297-846X
dc.contributor.researcheridABI-3846-2020
dc.contributor.researcheridAAO-9962-2020
dc.contributor.researcheridA-4421-2016
dc.contributor.researcheridAEX-4557-2022
dc.date.accessioned2024-11-05T10:12:40Z
dc.date.available2024-11-05T10:12:40Z
dc.date.issued2023-04-01
dc.description.abstractSplenectomy is indicated in transfusion-dependent thalassemia (TDT) only in certain situations. This study aimed to present the effectiveness, complications, and long-term follow-up results of splenectomy in children with TDT. We performed a 30-year single-institution analysis of cases of splenectomy for TDT between 1987 and 2017 and their follow-up until 2021. A total of 39 children (female/male: 24/15) were included. The mean age at splenectomy was 11.2 +/- 3.2 years, and their mean follow-up duration after splenectomy was 21.5 +/- 6.4 years. Response was defined according to the patient's annual transfusion requirement in the first year postsplenectomy and on the last follow-up year. Complete response was not seen in any of the cases; partial response was observed in 32.3% and no response in 67.6%. Thrombocytosis was seen in 87% of the patients. The platelet counts of 7 (17.9%) patients were >1000 (10(9)/L), and aspirin prophylaxis was given to 22 (56.4%) patients. Complications were thrombosis in 2 (5.1%) patients, infections in 11 (28.2%) patients, and pulmonary hypertension in 4 (10.2%) patients. Our study showed that after splenectomy, the need for transfusion only partially decreased in a small number of TDT patients. We think splenectomy can be delayed with appropriate chelation therapy up to higher annual transfusion requirement values.
dc.identifier.doi10.1097/MPH.0000000000002468
dc.identifier.endpage148
dc.identifier.issn1077-4114
dc.identifier.issue3
dc.identifier.startpage143
dc.identifier.urihttps://doi.org/10.1097/MPH.0000000000002468
dc.identifier.urihttps://hdl.handle.net/11452/47427
dc.identifier.volume45
dc.identifier.wos000957943100007
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.journalJournal Of Pediatric Hematology Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLaparoscopic splenectomy
dc.subjectMagnetic-resonance
dc.subjectChelation-therapy
dc.subjectPrevalence
dc.subjectStrategies
dc.subjectSepsis
dc.subjectSplenectomy
dc.subjectChildren
dc.subjectThalassemia
dc.subjectTransfusion-dependent
dc.subjectLong-term
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectOncology
dc.subjectPediatrics
dc.subjectHematology
dc.titleLong-term results of splenectomy in transfusion-dependent thalassemia
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Biyoistatistik Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
relation.isAuthorOfPublication4357973e-e9f1-4210-9941-a3f560720dd8
relation.isAuthorOfPublication648e85b9-2f4f-4f92-a2d7-794286abd0fd
relation.isAuthorOfPublication.latestForDiscovery4357973e-e9f1-4210-9941-a3f560720dd8

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