Publication:
Co-loading of Temozolomide with Oleuropein or rutin into polylactic acid core-shell nanofiber webs inhibit glioblastoma cell by controlled release

Simple item page
dc.contributor.authorErçelik, Melis
dc.contributor.authorTekin, Çağla
dc.contributor.authorParin, Fatma Nur
dc.contributor.authorMutlu, Büşra
dc.contributor.authorDoğan, Hazal Yılmaz
dc.contributor.authorTezcan, Gülçin
dc.contributor.authorAksoy, Seçil Ak
dc.contributor.authorGürbüz, Melisa
dc.contributor.authorYıldırım, Kenan
dc.contributor.authorBekar, Ahmet
dc.contributor.authorKocaeli, Hasan
dc.contributor.authorTaşkapılıoğlu, Mevlüt Özgür
dc.contributor.authorEser, Pınar
dc.contributor.authorTunca, Berrin
dc.contributor.buuauthorErçelik, Melis
dc.contributor.buuauthorTekin, Çağla
dc.contributor.buuauthorTEZCAN, GÜLÇİN
dc.contributor.buuauthorAksoy, Seçil Ak
dc.contributor.buuauthorGürbüz, Melisa
dc.contributor.buuauthorBEKAR, AHMET
dc.contributor.buuauthorKOCAELİ, HASAN
dc.contributor.buuauthorTAŞKAPILIOĞLU, MEVLÜT ÖZGÜR
dc.contributor.buuauthorEser, Pınar
dc.contributor.buuauthorTUNCA, BERRİN
dc.contributor.departmentDiş Hekimliği Fakültesi
dc.contributor.departmentBeyin Cerrahi Ana Bilim Dalı
dc.contributor.orcid0000-0002-1640-6035
dc.contributor.orcid0000-0003-0132-9927
dc.contributor.orcid0000-0002-1619-6680
dc.contributor.researcheridABX-9081-2022
dc.contributor.researcheridAAI-2073-2021
dc.contributor.researcheridHKM-7750-2023
dc.contributor.researcheridEUG-3329-2022
dc.contributor.researcheridGDC-6329-2022
dc.contributor.researcheridJJL-1176-2023
dc.contributor.researcheridJJH-2235-2023
dc.contributor.researcheridCGB-7869-2022
dc.contributor.researcheridFDK-3229-2022
dc.contributor.researcheridIRO-2619-2023
dc.date.accessioned2024-09-09T10:02:16Z
dc.date.available2024-09-09T10:02:16Z
dc.date.issued2023-09-03
dc.description.abstractGlioblastoma (GB) has susceptibility to post-surgical recurrence. Therefore, local treatment methods are required against recurrent GB cells in the post-surgical area. In this study, we developed a nanofiber-based local therapy against GB cells using Oleuropein (OL), and rutin and their combinations with Temozolomide (TMZ). The polylactic acid (PLA) coreshell nanofiber webs were encapsulated with OL (PLA(OL)), rutin (PLA(rutin)), and TMZ (PLA(TMZ)) by an electrospinning process. A SEM visualized the morphology and the total immersion method determined the release characteristics of PLA webs. Real-time cell tracking analysis for cell growth, dual Acridine Orange/Propidium Iodide staining for cell viability, a scratch wound healing assay for migration capacity, and a sphere formation assay for tumor spheroid aggressiveness were used. All polymeric nanofiber webs had core -shell structures with an average diameter between 133 +/- 30.7-139 +/- 20.5 nm. All PLA webs promoted apoptotic cell death, suppressed cell migration, and spheres growth (p < 0.0001). PLA(OL) and PLA(TMZ) suppressed GB cell viability with a controlled release that increased over 120 h, while PLA(rutin) caused rapid cell inhibition (p < 0.0001). Collectively, our findings suggest that core-shell nanowebs could be a novel and effective therapeutic tool for the controlled release of OL and TMZ against recurrent GB cells.
dc.description.sponsorship100/2000 The Council of Higher Education (CoHE)
dc.description.sponsorship2211-C priority areas PhD program scholarship
dc.identifier.doi10.1016/j.ijbiomac.2023.126722
dc.identifier.issn0141-8130
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2023.126722
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S014181302303619X?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11452/44396
dc.identifier.volume253
dc.identifier.wos001077751100001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherElsevier
dc.relation.journalInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak121S624
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSustained delivery
dc.subjectNanoparticles
dc.subjectRadiotherapy
dc.subjectCytotoxicity
dc.subjectScaffolds
dc.subjectPolymers
dc.subjectCurcumin
dc.subjectBehavior
dc.subjectTherapy
dc.subjectSystem
dc.subjectCombined treatment
dc.subjectGlioblastoma local treatment
dc.subjectNano-based drug delivery systems
dc.subjectBiochemistry & molecular biology
dc.subjectChemistry
dc.subjectPolymer science
dc.titleCo-loading of Temozolomide with Oleuropein or rutin into polylactic acid core-shell nanofiber webs inhibit glioblastoma cell by controlled release
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Biyoloji Ana Bilim Dalı
local.contributor.departmentDiş Hekimliği Fakültesi/Temel Bilimler Bölümü
local.contributor.departmentİnegöl Meslek Yüksekokulu
local.contributor.departmentTıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Birimi
local.contributor.departmentTıp Fakültesi/Beyin Cerrahi Ana Bilim Dalı
relation.isAuthorOfPublicatione171a866-0a2e-4df4-9f4b-d9058971c979
relation.isAuthorOfPublicatione929e321-8731-462f-8655-65e237321fef
relation.isAuthorOfPublication077eba38-acbc-49db-8784-0153575936ae
relation.isAuthorOfPublication5366e0c2-f020-4a2d-8d97-46928026680f
relation.isAuthorOfPublication121a3732-be5d-4aff-9195-357c8347daca
relation.isAuthorOfPublication.latestForDiscoverye171a866-0a2e-4df4-9f4b-d9058971c979

Files

Collections

Yeni Yayınlar