Publication:
Low molecular weight heparin-aspirin-prednisolone combination does not increase the live birth rate in recurrent implantation failure: A retrospective cohort study

dc.contributor.authorAslan, Kiper
dc.contributor.authorKasapoğlu, Işıl
dc.contributor.authorÇınar, Ceren
dc.contributor.authorÇakır, Cihan
dc.contributor.authorAvcı, Berrin
dc.contributor.authorUncu, Gürkan
dc.contributor.buuauthorASLAN, MÜNİR KİPER
dc.contributor.buuauthorKASAPOĞLU, IŞIL
dc.contributor.buuauthorÇINAR, CEREN
dc.contributor.buuauthorÇAKIR, CİHAN
dc.contributor.buuauthorAVCI, BERRİN
dc.contributor.buuauthorUNCU, GÜRKAN
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.
dc.contributor.orcid0000-0002-9277-7735
dc.contributor.orcid0000-0002-8332-7353
dc.contributor.researcheridAER-7173-2022
dc.contributor.researcheridCXJ-7203-2022
dc.contributor.researcheridIUD-1217-2023
dc.contributor.researcheridAAH-5249-2021
dc.contributor.researcheridELU-2357-2022
dc.contributor.researcheridAAT-3479-2021
dc.date.accessioned2024-10-04T13:14:33Z
dc.date.available2024-10-04T13:14:33Z
dc.date.issued2023-05-30
dc.description.abstractThis study investigates the triple combination of adjuvants (low molecular weight heparin (LMWH)-aspirin-prednisolone) whether it improves the live birth rates of IVF&ICSI patients with previous implantation failure. This retrospective study included 1095 patients with >2 failed either fresh or frozen single embryo transfer cycles between 2014 Jan and 2021 Jan. Patients were divided into two subgroups. Group A consisted of patients with only vaginal progesterone for luteal phase support. Group B consisted of patients with triple (daily subcutaneous LMWH, daily 150 mg aspirin, and daily 16 mg prednisolone) luteal phase supplementation to vaginal progesterone. Demographic parameters, cycle characteristics, embryology, and pregnancy outcomes were compared, and the study's primary outcome was the live birth rate. Demographic parameters were similar between the groups. Positive b-hCG, miscarriage, and live birth rates were similar between groups as Group A vs. Group B, positive b-hCG 30.8% (190/617) vs. 35.4% (169/478), miscarriage rates 4.4% (27/617) vs. 6.7% (32/478), and live birth rates 20.4% (126/617) vs. 23.8% (114/478), respectively. When patients were stratified according to previous failures, live birth rates were still similar. Pregnancy outcomes were significantly improved in only patients with diminished ovarian reserve (Group A vs. Group B, positive b-hCG 24.2% vs. 34.3%, live birth rate 12.1% vs. 21.9%, p < 0.01). Whether the embryo transfer was fresh or frozen-thawed did not affect the results. A combined supplementation of LMWH, aspirin, and prednisolone in the luteal phase does not improve live birth rates of IVF&ICSI patients with previous implantation failure except potentially for patients with diminished ovarian reserve.
dc.identifier.doi10.1007/s43032-023-01233-9
dc.identifier.endpage3260
dc.identifier.issn1933-7191
dc.identifier.issue11
dc.identifier.startpage3253
dc.identifier.urihttps://doi.org/10.1007/s43032-023-01233-9
dc.identifier.urihttps://link.springer.com/article/10.1007/s43032-023-01233-9
dc.identifier.urihttps://hdl.handle.net/11452/45906
dc.identifier.volume30
dc.identifier.wos000999630100002
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.journalReproductive Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEpidermal-growth-factor
dc.subjectIn-vitro fertilization
dc.subjectLow-dose aspirin
dc.subjectBlood-flow
dc.subjectPregnancy
dc.subjectIvf
dc.subjectDefinition
dc.subjectUterine
dc.subjectPreeclampsia
dc.subjectPrevention
dc.subjectLow molecular weight heparin
dc.subjectAspirin
dc.subjectPrednisolone
dc.subjectImplantation failure
dc.subjectInfertility
dc.subjectDiminished ovarian reserve
dc.subjectObstetrics & gynecology
dc.subjectReproductive biology
dc.titleLow molecular weight heparin-aspirin-prednisolone combination does not increase the live birth rate in recurrent implantation failure: A retrospective cohort study
dc.typeArticle
dspace.entity.typePublication
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