Publication:
Therapeutic applications of curcumin nanomedicine formulations in cystic fibrosis

dc.contributor.authorQuispe, Cristina
dc.contributor.authorHerrera-Bravo, Jesus
dc.contributor.authorKhan, Khushbukhat
dc.contributor.authorJaved, Zeeshan
dc.contributor.authorSemwal, Prabhakar
dc.contributor.authorPainuli, Sakshi
dc.contributor.authorMartorell, Miquel
dc.contributor.authorCalina, Daniela
dc.contributor.authorSharifi-Rad, Javad
dc.contributor.buuauthorKamiloğlu, Senem
dc.contributor.buuauthorKAMİLOĞLU BEŞTEPE, SENEM
dc.contributor.departmentBursa Uludağ Üniversitesi/Bilim ve Teknoloji Uygulama ve Araştırma Merkezi.
dc.contributor.researcheridP-3633-2018
dc.date.accessioned2024-10-14T13:13:04Z
dc.date.available2024-10-14T13:13:04Z
dc.date.issued2022-07-29
dc.description.abstractMedicinal applications of turmeric-derived curcumin have been known to mankind for long ages. Its potential in managing "cystic fibrosis" has also been evaluated. This autosomal recessive genetic disease is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) which involves an impaired secretion of chloride ions and leads to hypersecretion of thick and sticky mucus and serious complications including airway obstruction, chronic lung infection, and inflammatory reactions. This narrative review aims to highlight the available evidence for the efficacy of curcumin nanoformulations in its potential treatment of cystic fibrosis. Recent research has shown that curcumin acts on the localized mutant CFTR ion channel at the plasma membrane. Preclinical studies have also shown that curcumin nanoformulations have promising effects in the treatment of cystic fibrosis. In this context, the purpose of this narrative review is to highlight the general bioactivity of curcumin, the types of formulations and related studies, thus opening new therapeutic perspectives for CF.
dc.identifier.doi10.1007/s40204-022-00198-3
dc.identifier.endpage329
dc.identifier.issn2194-0509
dc.identifier.issue4
dc.identifier.startpage321
dc.identifier.urihttps://doi.org/10.1007/s40204-022-00198-3
dc.identifier.urihttps://hdl.handle.net/11452/46391
dc.identifier.volume11
dc.identifier.wos000832809200001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.journalProgress In Biomaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTransmembrane conductance regulator
dc.subjectMesoporous silica nanoparticles
dc.subjectPseudomonas-aeruginosa
dc.subjectPlga nanoparticles
dc.subjectCo-delivery
dc.subjectDesign
dc.subjectExpression
dc.subjectStrategy
dc.subjectRescue
dc.subjectCftr
dc.subjectCystic fibrosis
dc.subjectCurcumin nanoparticles
dc.subjectBioavailability
dc.subjectMolecular mechanisms
dc.subjectSignalling pathways
dc.subjectScience & technology
dc.subjectTechnology
dc.subjectEngineering, biomedical
dc.subjectMaterials science, biomaterials
dc.subjectEngineering
dc.subjectMaterials science
dc.titleTherapeutic applications of curcumin nanomedicine formulations in cystic fibrosis
dc.typeReview
dspace.entity.typePublication
relation.isAuthorOfPublication5b927446-2c67-44ca-9435-3496356c40be
relation.isAuthorOfPublication.latestForDiscovery5b927446-2c67-44ca-9435-3496356c40be

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