Publication:
Riluzole is effective on spinal decompression for treating acute spinal injury when compared with methylprednisolone and the combination of two drugs: In vivo rat model

dc.contributor.authorÖnder, Çiğdem
dc.contributor.buuauthorÖnder, Cem
dc.contributor.buuauthorÖNDER, CEM
dc.contributor.buuauthorAkesen, Selcan
dc.contributor.buuauthorAKESEN, SELCAN
dc.contributor.buuauthorAkesen, Burak
dc.contributor.buuauthorAKESEN, BURAK
dc.contributor.buuauthorYumusak, Ezgi
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Ortopedi ve Travmotoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
dc.contributor.orcid0000-0002-7773-3419
dc.contributor.researcheridHKW-7185-2023
dc.date.accessioned2024-09-09T07:28:11Z
dc.date.available2024-09-09T07:28:11Z
dc.date.issued2023-02-22
dc.description.abstractStudy Design Randomized controlled animal experiment. Objectives To determine and compare the efficacy of riluzole, MPS and the combination of two drugs in a rat model with acute spinal trauma, electrophysiologically and histopathologically. Methods 59 rats were divided into 4 groups as control, riluzole (6 mg/kg, every 12 hours for 7 days), MPS (30 mg/kg, 2nd and 4th hours after injury) and riluzole + MPS. Spinal trauma was created and the subjects were followed for 7 days. Electrophysiological recordings were made via neuromonitoring. The subjects were sacrificed and histopathological examination was made. Results For the amplitude values, mean alteration in the period from the spinal cord injury to the end of the 7th day is 15.89 +/- 20.00%, 210.93 +/- 199.44%, 24.75% +/- 10.13% increase and 18.91 +/- 30.01% decrease for the control, riluzole, riluzole + MPS and MPS groups, respectively. Although the riluzole treatment group produced the greatest increase in amplitude, it was observed that no treatment provided a significant improvement compared to the control group, in terms of latency and amplitude. It was observed that there was significantly less cavitation area in the riluzole treatment group compared to the control group (P = .020). (P < .05). Conclusions Electrophysiologically, no treatment was found to provide significant improvement. Histopathologically, it was observed that riluzole provided significant neural tissue protection.
dc.identifier.doi10.1177/21925682231159068
dc.identifier.issn2192-5682
dc.identifier.urihttps://doi.org/10.1177/21925682231159068
dc.identifier.urihttps://hdl.handle.net/11452/44392
dc.identifier.wos000936267900001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.journalGlobal Spine Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTranscranial magnetic stimulation
dc.subjectHigh-dose methylprednisolone
dc.subjectCord-injury
dc.subjectAmino-acids
dc.subjectLipid-peroxidation
dc.subjectGene-expression
dc.subjectMotor
dc.subjectMechanisms
dc.subjectAnesthesia
dc.subjectManagement
dc.subjectRiluzole
dc.subjectMethylprednisolone
dc.subjectSpinal injuries
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectClinical neurology
dc.subjectOrthopedics
dc.subjectNeurosciences & neurology
dc.titleRiluzole is effective on spinal decompression for treating acute spinal injury when compared with methylprednisolone and the combination of two drugs: In vivo rat model
dc.typeArticle
dc.typeEarly Access
dspace.entity.typePublication
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relation.isAuthorOfPublication7d69bf4b-5b6e-4ffb-8c62-24c57cf808aa
relation.isAuthorOfPublication.latestForDiscoveryeaf7c6a9-98a0-4b57-b201-77f2d8d7da73

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