Publication:
Correlation between arterial stiffness and inflammatory markers in autosomal dominant polycystic kidney disease patients with preserved renal function

dc.contributor.authorGül, Cuma Bülent
dc.contributor.authorYıldız, Abdülmecit
dc.contributor.authorErsoy, Alparslan
dc.contributor.authorKahvecioğlu, Serdar
dc.contributor.authorAsiltaş, Burak
dc.contributor.authorYıldırım, Fatih
dc.contributor.authorErmurat, Selime
dc.contributor.authorSağ, Saim
dc.contributor.authorOruç, Ayşegül
dc.contributor.authorGüllülü, Sumeyye
dc.contributor.authorGüllülü, Mustafa
dc.contributor.buuauthorYILDIZ, ABDULMECİT
dc.contributor.buuauthorERSOY, ALPARSLAN
dc.contributor.buuauthorAsıltaş, Burak
dc.contributor.buuauthorYILDIRIM, FATİH
dc.contributor.buuauthorErmurat, Selime
dc.contributor.buuauthorSağ, Saim
dc.contributor.buuauthorORUÇ, AYŞEGÜL
dc.contributor.buuauthorGÜLLÜLÜ, NAZMİYE SÜMEYYE
dc.contributor.buuauthorGÜLLÜLÜ, MUSTAFA
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.
dc.contributor.orcid0000-0003-2467-9356
dc.contributor.orcid0000-0002-0342-9692
dc.contributor.orcid0000-0002-3090-1585
dc.contributor.orcid0000-0001-8404-8252
dc.contributor.researcheridHIG-9032-2022
dc.contributor.researcheridAAH-5054-2021
dc.contributor.researcheridJCN-7114-2023
dc.contributor.researcheridAAH-4002-2021
dc.contributor.researcheridABE-4424-2022
dc.contributor.researcheridAAW-9185-2020
dc.contributor.researcheridEKV-7386-2022
dc.contributor.researcheridEXG-3181-2022
dc.contributor.researcheridCTG-8811-2022
dc.date.accessioned2024-08-12T08:00:32Z
dc.date.available2024-08-12T08:00:32Z
dc.date.issued2015-07-01
dc.description.abstractTo evaluate the association between arterial stiffness and inflammatory markers including C-reactive protein (CRP), pentraxin 3 (PTX3) and neutrophil-to-lymphocyte ratio (NLR) in autosomal dominant polycystic kidney disease (ADPKD) patients with preserved renal function.A total of 52 ADPKD patients [mean (SD) age 38.2 (12.8) years, 69.2 % were females] with preserved renal function and 25 healthy volunteers [mean (SD) age 35.5 (6.5) years, 48.0 % were females] were included. Data on patient characteristics, blood biochemistry, inflammatory markers [PTX3 (pg/mL), CRP (mg/dL) and NLR] and arterial stiffness [large artery elasticity index (LAEI) (mL/mmHg x 10) and small artery elasticity index (SAEI) (mL/mmHg x 100)] were recorded in patient and control groups. Correlation between inflammatory markers and arterial stiffness parameters was analysed in patients.Overall, 42.3 % of ADPKD patients were hypertensive and 44.4 % were receiving renin-angiotensin-aldosterone system (RAAS) blockade therapy. Median levels for PTX3 [442.0 (20.0-4140.0) pg/mL vs. 220.5 (14.7-393.0) pg/mL, p < 0.001] and SAEI [4.90 (1.60-11.80) mL/mmHg x 100 vs. 6.45 (2.80-15.70) mL/mmHg x 10, p = 0.013] were significantly higher in ADPKD patients than in controls. PTX3 and CRP were not correlated with arterial elasticity, while NLR was significantly correlated with LAEI negatively (Rho = -0.278, p = 0.042).In conclusion, our findings revealed increased PTX3 levels and reduced SAEI in patients as compared with controls, while no correlation between inflammatory markers studied and the small artery elasticity.
dc.identifier.doi10.1007/s11255-015-1022-0
dc.identifier.endpage1194
dc.identifier.issn0301-1623
dc.identifier.issue7
dc.identifier.startpage1187
dc.identifier.urihttps://doi.org/10.1007/s11255-015-1022-0
dc.identifier.urihttps://link.springer.com/article/10.1007/s11255-015-1022-0
dc.identifier.urihttps://hdl.handle.net/11452/43897
dc.identifier.volume47
dc.identifier.wos000356902100022
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer
dc.relation.journalInternational Urology and Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTo-lymphocyte ratio
dc.subjectEndothelial dysfunction
dc.subjectHemodialysis-patients
dc.subjectPentraxin-3
dc.subjectAssociations
dc.subjectElasticity
dc.subjectRisk
dc.subjectHypertension
dc.subjectMortality
dc.subjectProtein
dc.subjectAutosomal dominant polycystic kidney disease
dc.subjectArterial stiffness
dc.subjectArterial elasticity
dc.subjectEndothelial dysfunction
dc.subjectInflammatory markers
dc.subjectUrology & nephrology
dc.titleCorrelation between arterial stiffness and inflammatory markers in autosomal dominant polycystic kidney disease patients with preserved renal function
dc.typeArticle
dspace.entity.typePublication
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