Publication: Correlation between arterial stiffness and inflammatory markers in autosomal dominant polycystic kidney disease patients with preserved renal function
dc.contributor.author | Gül, Cuma Bülent | |
dc.contributor.author | Yıldız, Abdülmecit | |
dc.contributor.author | Ersoy, Alparslan | |
dc.contributor.author | Kahvecioğlu, Serdar | |
dc.contributor.author | Asiltaş, Burak | |
dc.contributor.author | Yıldırım, Fatih | |
dc.contributor.author | Ermurat, Selime | |
dc.contributor.author | Sağ, Saim | |
dc.contributor.author | Oruç, Ayşegül | |
dc.contributor.author | Güllülü, Sumeyye | |
dc.contributor.author | Güllülü, Mustafa | |
dc.contributor.buuauthor | YILDIZ, ABDULMECİT | |
dc.contributor.buuauthor | ERSOY, ALPARSLAN | |
dc.contributor.buuauthor | Asıltaş, Burak | |
dc.contributor.buuauthor | YILDIRIM, FATİH | |
dc.contributor.buuauthor | Ermurat, Selime | |
dc.contributor.buuauthor | Sağ, Saim | |
dc.contributor.buuauthor | ORUÇ, AYŞEGÜL | |
dc.contributor.buuauthor | GÜLLÜLÜ, NAZMİYE SÜMEYYE | |
dc.contributor.buuauthor | GÜLLÜLÜ, MUSTAFA | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı. | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı. | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı. | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı. | |
dc.contributor.orcid | 0000-0003-2467-9356 | |
dc.contributor.orcid | 0000-0002-0342-9692 | |
dc.contributor.orcid | 0000-0002-3090-1585 | |
dc.contributor.orcid | 0000-0001-8404-8252 | |
dc.contributor.researcherid | HIG-9032-2022 | |
dc.contributor.researcherid | AAH-5054-2021 | |
dc.contributor.researcherid | JCN-7114-2023 | |
dc.contributor.researcherid | AAH-4002-2021 | |
dc.contributor.researcherid | ABE-4424-2022 | |
dc.contributor.researcherid | AAW-9185-2020 | |
dc.contributor.researcherid | EKV-7386-2022 | |
dc.contributor.researcherid | EXG-3181-2022 | |
dc.contributor.researcherid | CTG-8811-2022 | |
dc.date.accessioned | 2024-08-12T08:00:32Z | |
dc.date.available | 2024-08-12T08:00:32Z | |
dc.date.issued | 2015-07-01 | |
dc.description.abstract | To evaluate the association between arterial stiffness and inflammatory markers including C-reactive protein (CRP), pentraxin 3 (PTX3) and neutrophil-to-lymphocyte ratio (NLR) in autosomal dominant polycystic kidney disease (ADPKD) patients with preserved renal function.A total of 52 ADPKD patients [mean (SD) age 38.2 (12.8) years, 69.2 % were females] with preserved renal function and 25 healthy volunteers [mean (SD) age 35.5 (6.5) years, 48.0 % were females] were included. Data on patient characteristics, blood biochemistry, inflammatory markers [PTX3 (pg/mL), CRP (mg/dL) and NLR] and arterial stiffness [large artery elasticity index (LAEI) (mL/mmHg x 10) and small artery elasticity index (SAEI) (mL/mmHg x 100)] were recorded in patient and control groups. Correlation between inflammatory markers and arterial stiffness parameters was analysed in patients.Overall, 42.3 % of ADPKD patients were hypertensive and 44.4 % were receiving renin-angiotensin-aldosterone system (RAAS) blockade therapy. Median levels for PTX3 [442.0 (20.0-4140.0) pg/mL vs. 220.5 (14.7-393.0) pg/mL, p < 0.001] and SAEI [4.90 (1.60-11.80) mL/mmHg x 100 vs. 6.45 (2.80-15.70) mL/mmHg x 10, p = 0.013] were significantly higher in ADPKD patients than in controls. PTX3 and CRP were not correlated with arterial elasticity, while NLR was significantly correlated with LAEI negatively (Rho = -0.278, p = 0.042).In conclusion, our findings revealed increased PTX3 levels and reduced SAEI in patients as compared with controls, while no correlation between inflammatory markers studied and the small artery elasticity. | |
dc.identifier.doi | 10.1007/s11255-015-1022-0 | |
dc.identifier.endpage | 1194 | |
dc.identifier.issn | 0301-1623 | |
dc.identifier.issue | 7 | |
dc.identifier.startpage | 1187 | |
dc.identifier.uri | https://doi.org/10.1007/s11255-015-1022-0 | |
dc.identifier.uri | https://link.springer.com/article/10.1007/s11255-015-1022-0 | |
dc.identifier.uri | https://hdl.handle.net/11452/43897 | |
dc.identifier.volume | 47 | |
dc.identifier.wos | 000356902100022 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Springer | |
dc.relation.journal | International Urology and Nephrology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | To-lymphocyte ratio | |
dc.subject | Endothelial dysfunction | |
dc.subject | Hemodialysis-patients | |
dc.subject | Pentraxin-3 | |
dc.subject | Associations | |
dc.subject | Elasticity | |
dc.subject | Risk | |
dc.subject | Hypertension | |
dc.subject | Mortality | |
dc.subject | Protein | |
dc.subject | Autosomal dominant polycystic kidney disease | |
dc.subject | Arterial stiffness | |
dc.subject | Arterial elasticity | |
dc.subject | Endothelial dysfunction | |
dc.subject | Inflammatory markers | |
dc.subject | Urology & nephrology | |
dc.title | Correlation between arterial stiffness and inflammatory markers in autosomal dominant polycystic kidney disease patients with preserved renal function | |
dc.type | Article | |
dspace.entity.type | Publication | |
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