Publication: The OVLT initiates the fall in arterial pressure evoked by high dose lipopolysaccharide: Evidence that dichotomous, dose-related mechanisms mediate endotoxic hypotension
dc.contributor.author | Feleder, Carlos | |
dc.contributor.author | Yılmaz, M. Sertaç | |
dc.contributor.author | Peng, Jianya | |
dc.contributor.author | Göktalay, Gökhan | |
dc.contributor.author | Millington, William R. | |
dc.contributor.buuauthor | YILMAZ, MUSTAFA SERTAÇ | |
dc.contributor.buuauthor | GÖKTALAY, GÖKHAN | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı. | |
dc.contributor.orcid | 0000-0001-9496-1475 | |
dc.contributor.orcid | 0000-0002-2617-3626 | |
dc.contributor.researcherid | AAH-1448-2021 | |
dc.contributor.researcherid | AAH-1571-2021 | |
dc.date.accessioned | 2024-08-13T10:20:00Z | |
dc.date.available | 2024-08-13T10:20:00Z | |
dc.date.issued | 2015-05-27 | |
dc.description.abstract | This study tested the hypothesis that lipopolysaccharide (LPS) lowers arterial pressure through two different mechanisms depending on the dose. Previously, we found that a low hypotensive dose of LPS (1 mg/kg) lowers arterial pressure by activating vagus nerve afferents. Here we report that hypotension evoked by high dose LPS (15 mg/kg) can be prevented by injecting lidocaine into the OVLT but not by vagotomy or inactivation of the NTS. The hypotension produced by both LPS doses was correlated with elevated extracellular norepinephrine concentrations in the POA and prevented by blocking alpha-adrenergic receptors. Thus, initiation of endotoxic hypotension is dose-related, mechanistically. (C) 2015 Elsevier B.V. All rights reserved. | |
dc.description.sponsorship | United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Allergy & Infectious Diseases (NIAID) R15AI072744 | |
dc.identifier.doi | 10.1016/j.jneuroim.2015.05.023 | |
dc.identifier.endpage | 100 | |
dc.identifier.issn | 0165-5728 | |
dc.identifier.startpage | 94 | |
dc.identifier.uri | https://doi.org/10.1016/j.jneuroim.2015.05.023 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0165572815001563 | |
dc.identifier.uri | https://hdl.handle.net/11452/43971 | |
dc.identifier.volume | 285 | |
dc.identifier.wos | 000359175100014 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.relation.journal | Journal of Neuroimmunology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Ventrolateral periaqueductal gray | |
dc.subject | Vasculosum-laminae-terminalis | |
dc.subject | Organum-vasculosum | |
dc.subject | Vagus nerve | |
dc.subject | Preoptic nucleus | |
dc.subject | Thermoregulatory response | |
dc.subject | Subdiaphragmatic vagotomy | |
dc.subject | Rat | |
dc.subject | Fever | |
dc.subject | Sepsis | |
dc.subject | Endotoxin | |
dc.subject | Lipopolysaccharide | |
dc.subject | Septic shock | |
dc.subject | Ovlt | |
dc.subject | Preoptic area | |
dc.subject | Immunology | |
dc.subject | Neurosciences & neurology | |
dc.title | The OVLT initiates the fall in arterial pressure evoked by high dose lipopolysaccharide: Evidence that dichotomous, dose-related mechanisms mediate endotoxic hypotension | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | b8126534-324f-44c7-9d6f-2d2bef667926 | |
relation.isAuthorOfPublication | c134bdf1-13f0-4729-829d-1f6b6b68d435 | |
relation.isAuthorOfPublication.latestForDiscovery | b8126534-324f-44c7-9d6f-2d2bef667926 |
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