Publication:
The OVLT initiates the fall in arterial pressure evoked by high dose lipopolysaccharide: Evidence that dichotomous, dose-related mechanisms mediate endotoxic hypotension

dc.contributor.authorFeleder, Carlos
dc.contributor.authorYılmaz, M. Sertaç
dc.contributor.authorPeng, Jianya
dc.contributor.authorGöktalay, Gökhan
dc.contributor.authorMillington, William R.
dc.contributor.buuauthorYILMAZ, MUSTAFA SERTAÇ
dc.contributor.buuauthorGÖKTALAY, GÖKHAN
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.
dc.contributor.orcid0000-0001-9496-1475
dc.contributor.orcid0000-0002-2617-3626
dc.contributor.researcheridAAH-1448-2021
dc.contributor.researcheridAAH-1571-2021
dc.date.accessioned2024-08-13T10:20:00Z
dc.date.available2024-08-13T10:20:00Z
dc.date.issued2015-05-27
dc.description.abstractThis study tested the hypothesis that lipopolysaccharide (LPS) lowers arterial pressure through two different mechanisms depending on the dose. Previously, we found that a low hypotensive dose of LPS (1 mg/kg) lowers arterial pressure by activating vagus nerve afferents. Here we report that hypotension evoked by high dose LPS (15 mg/kg) can be prevented by injecting lidocaine into the OVLT but not by vagotomy or inactivation of the NTS. The hypotension produced by both LPS doses was correlated with elevated extracellular norepinephrine concentrations in the POA and prevented by blocking alpha-adrenergic receptors. Thus, initiation of endotoxic hypotension is dose-related, mechanistically. (C) 2015 Elsevier B.V. All rights reserved.
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Allergy & Infectious Diseases (NIAID) R15AI072744
dc.identifier.doi10.1016/j.jneuroim.2015.05.023
dc.identifier.endpage100
dc.identifier.issn0165-5728
dc.identifier.startpage94
dc.identifier.urihttps://doi.org/10.1016/j.jneuroim.2015.05.023
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0165572815001563
dc.identifier.urihttps://hdl.handle.net/11452/43971
dc.identifier.volume285
dc.identifier.wos000359175100014
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherElsevier
dc.relation.journalJournal of Neuroimmunology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVentrolateral periaqueductal gray
dc.subjectVasculosum-laminae-terminalis
dc.subjectOrganum-vasculosum
dc.subjectVagus nerve
dc.subjectPreoptic nucleus
dc.subjectThermoregulatory response
dc.subjectSubdiaphragmatic vagotomy
dc.subjectRat
dc.subjectFever
dc.subjectSepsis
dc.subjectEndotoxin
dc.subjectLipopolysaccharide
dc.subjectSeptic shock
dc.subjectOvlt
dc.subjectPreoptic area
dc.subjectImmunology
dc.subjectNeurosciences & neurology
dc.titleThe OVLT initiates the fall in arterial pressure evoked by high dose lipopolysaccharide: Evidence that dichotomous, dose-related mechanisms mediate endotoxic hypotension
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationb8126534-324f-44c7-9d6f-2d2bef667926
relation.isAuthorOfPublicationc134bdf1-13f0-4729-829d-1f6b6b68d435
relation.isAuthorOfPublication.latestForDiscoveryb8126534-324f-44c7-9d6f-2d2bef667926

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