Publication:
Distribution of hepatitis c virus genotypes in the south Marmara Region

dc.contributor.buuauthorAğca, Harun
dc.contributor.buuauthorAĞCA, HARUN
dc.contributor.buuauthorMistik, Reşit
dc.contributor.buuauthorKazak, Esra
dc.contributor.buuauthorKAZAK, ESRA
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.
dc.contributor.orcid0000-0002-2651-2034
dc.contributor.researcheridISU-9626-2023
dc.contributor.researcheridAAG-8459-2021
dc.contributor.researcheridAAH-4027-2021
dc.date.accessioned2024-10-21T11:28:18Z
dc.date.available2024-10-21T11:28:18Z
dc.date.issued2015-03-01
dc.description.abstractAim: Hepatitis C virus (HCV) is an important caustive agent of hepatitis, cirrhosis and hepatocellular carcinoma both in our country and the world. Prognosis and response to treatment is related with the genotype of HCV which has six genotypes and over a hundred quasispecies. Knowing the HCV genotype is also important for epidemiological data. In this study we aimed to investigate the HCV genotypes of samples sent to Uludag University Hospital Microbiology Laboratory which is the reference centre in the South Marmara Region. Material and Method: This study was done retrospectively to analyse the HCV patients' sera sent to our laboratory between July 2010 and December 2012 for HCV genotyping. Artus HCV QS-RGQ PCR kit (Qiagene, Hilden, Germany) was used in Rotor-Gene Q (Qiagene, Hilden Germany) for detection of HCV RNA. HCV RNA positive samples of patients' sera were were used for genotyping by the Linear Array HCV genotyping test (Roche, NJ, USA). Results: 214 (92.6 %) of total 231 patients included in the study were genotype 1, one (0.4 %) was genotype 2, nine (3.9 %) were genotype 3 and, seven (3.4 %) were found genotype 4. Three of genotype 3 patients were of foreign nationality, two were born abroad and one of the genotype 4 patients were born abroad. Discussion: Concordant with our country data the most frequent genotype was 1, genotype 2 was seen in patients especially related with foreign countries and genotype 4 was seen rare. The importance of genotype 1, which is seen more frequent in our country and region is; resistance to antiviral treatment and prolonged treatment duration in chronic hepatitis C patients.
dc.identifier.doi10.4328/JCAM.1954
dc.identifier.endpage192
dc.identifier.issn1309-0720
dc.identifier.issue2
dc.identifier.startpage190
dc.identifier.urihttps://doi.org/10.4328/JCAM.1954
dc.identifier.urihttps://hdl.handle.net/11452/46777
dc.identifier.volume6
dc.identifier.wos000376563600028
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherDerman Medical Publ
dc.relation.journalJournal Of Clinical And Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHcv genotypes
dc.subjectBoceprevir
dc.subjectTelaprevir
dc.subjectProvince
dc.subjectHcv
dc.subjectGenotype
dc.subjectTreatment
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectMedicine, general & internal
dc.subjectGeneral & internal medicine
dc.titleDistribution of hepatitis c virus genotypes in the south Marmara Region
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationeeb102e3-a297-417f-962b-8b6991f5b89b
relation.isAuthorOfPublication44aa832e-512b-446e-b095-bd59406744bd
relation.isAuthorOfPublication.latestForDiscoveryeeb102e3-a297-417f-962b-8b6991f5b89b

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