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An observational, multicenter, registry-based cohort study of Turkish neonatal society in neonates with hypoxic ischemic encephalopathy

dc.contributor.authorOkulu, Emel
dc.contributor.authorHirfanoğlu, İbrahim Murat
dc.contributor.authorSatar, Mehmet
dc.contributor.authorErdeve, Ömer
dc.contributor.authorKoç, Esin
dc.contributor.authorÖzlü, Ferda
dc.contributor.authorGökçe, Mahmut
dc.contributor.authorArmangil, Didem
dc.contributor.authorTunc, Gaffari
dc.contributor.authorDemirel, Nihal
dc.contributor.authorÜnal, Sezin
dc.contributor.authorÖzdemir, Ramazan
dc.contributor.authorDeveci, Mehmet Fatih
dc.contributor.authorAkar, Melek
dc.contributor.authorDemirel, Melike Kefeli
dc.contributor.authorÇetinkaya, Merih
dc.contributor.authorBuker, Halime Sema Can
dc.contributor.authorKaragöl, Belma Saygılı
dc.contributor.authorYaprak, Deniz
dc.contributor.authorAkcan, Abdullah Barış
dc.contributor.authorAnik, Ayşe
dc.contributor.authorNarter, Fatma
dc.contributor.authorArayıcı, Sema
dc.contributor.authorYıldırım, Egemen
dc.contributor.authorAkın, Ilke Mungan
dc.contributor.authorŞahin, Özlem
dc.contributor.authorÖzdemir, Özgül Emel Bulut
dc.contributor.authorOvalı, Fahri
dc.contributor.authorAkın, Mustafa Ali
dc.contributor.authorÇelik, Yalçın
dc.contributor.authorOrman, Ayşen
dc.contributor.authorUslu, Sinan
dc.contributor.authorTaştekin, Ayhan
dc.contributor.authorGündüz, Mehmet
dc.contributor.authorArısoy, Ayşe Engin
dc.contributor.authorGürpınar, Reşat
dc.contributor.authorOrs, Rahmi
dc.contributor.authorAltunhan, Hüseyin
dc.contributor.authorKeçeci, Ramazan
dc.contributor.authorYıldızdas, Hacer Yapıcıoğlu
dc.contributor.authorTerek, Demet
dc.contributor.authorAteş, Mehmet
dc.contributor.authorKader, Şebnem
dc.contributor.authorMutlu, Mehmet
dc.contributor.authorÇelik, Kıymet
dc.contributor.authorYücesoy, Ebru
dc.contributor.authorMert, Mustafa Kurthan
dc.contributor.authorGulasi, Selvi
dc.contributor.authorKüçüktasçı, Kazım
dc.contributor.authorArman, Didem
dc.contributor.authorHekimoğlu, Berna
dc.contributor.authorGültekin, Nazlı Dilay
dc.contributor.authorÇelik, Hasan Tolga
dc.contributor.authorKahvecioğlu, Dilek
dc.contributor.authorAkyıldız, Can
dc.contributor.authorTaşkın, Erdal
dc.contributor.authorÇiftdemir, Nukhet Aladag
dc.contributor.authorUygun, Saime Sündüs
dc.contributor.authorKaya, Tuğba Barsan
dc.contributor.authorAkdağ, Arzu
dc.contributor.authorYılmaz, Aslan
dc.contributor.buuauthorÖzkan, Hilal
dc.contributor.buuauthorÖZKAN, HİLAL
dc.contributor.buuauthorKöksal, Nilgün
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentÇocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.contributor.researcheridIGT-7005-2023
dc.contributor.researcheridCZV-1969-2022
dc.date.accessioned2024-12-03T05:16:40Z
dc.date.available2024-12-03T05:16:40Z
dc.date.issued2023-12-14
dc.description.abstractBackground Hypoxic ischemic encephalopathy (HIE) is a significant cause of mortality and short- and long-term morbidities. Therapeutic hypothermia (TH) has been shown to be the standard care for HIE of infants >= 36 weeks gestational age (GA), as it has been demonstrated to reduce the rates of mortality, and adverse neurodevelopmental outcomes. This study aims to determine the incidence of HIE in our country, to assess the TH management in infants with HIE, and present short-term outcomes of these infants. Methods The Turkish Hypoxic Ischemic Encephalopathy Online Registry database was established for this multicenter, prospective, observational, nationally-based cohort study to evaluate the data of infants born at >= 34 weeks GA who displayed evidence of neonatal encephalopathy (NE) between March, 2020 and April 2022. Results The incidence of HIE among infants born at >= 36 weeks GA (n = 965) was 2.13 per 1000 live births (517:242440), and accounting for 1.55% (965:62062) of all neonatal intensive care unit admissions. The rates of mild, moderate and severe HIE were 25.5% (n = 246), 58.9% (n = 568), and 15.6% (n = 151), respectively. Infants with severe HIE had higher rates of abnormal magnetic resonance imaging (MRI) findings, and mortality (p<0.001). No significant difference in mortality and abnormal MRI results was found according to the time of TH initiation (<3 h, 3-6 h and >6 h) (p>0.05). TH was administered to 85 (34.5%) infants with mild HIE, and of those born of 34-35 weeks of GA, 67.4% (n = 31) received TH. A total of 58 (6%) deaths were reported with a higher mortality rate in infants born at 34-35 weeks of GA (OR 3.941, 95% Cl 1.446-10.7422, p = 0.007). Conclusion The incidence of HIE remained similar over time with a reduction in mortality rate. The timing of TH initiation, whether <3 or 3-6 h, did not result in lower occurrences of brain lesions on MRI or mortality. An increasing number of infants with mild HIE and late preterm infants with HIE are receiving TH; however, the indications for TH require further clarification. Longer follow-up studies are necessary for this vulnerable population.
dc.identifier.doi10.1371/journal.pone.0295759
dc.identifier.issn1932-6203
dc.identifier.issue12
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0295759
dc.identifier.urihttps://hdl.handle.net/11452/48784
dc.identifier.volume18
dc.identifier.wos001158744900075
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherPublic Library Science
dc.relation.journalPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectWhole-body hypothermia
dc.subjectTherapeutic hypothermia
dc.subjectTerm
dc.subjectNewborns
dc.subjectOutcomes
dc.subjectInfants
dc.subjectDysfunction
dc.subjectSeverity
dc.subjectInjury
dc.subjectScience & technology
dc.subjectMultidisciplinary sciences
dc.subjectScience & technology - other topics
dc.titleAn observational, multicenter, registry-based cohort study of Turkish neonatal society in neonates with hypoxic ischemic encephalopathy
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
relation.isAuthorOfPublication67242d15-556e-43b2-a23e-e80ce158b468
relation.isAuthorOfPublication.latestForDiscovery67242d15-556e-43b2-a23e-e80ce158b468

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