Publication: The effect of topical 5-fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve
dc.contributor.author | Çavuş Özkan, Melekber | |
dc.contributor.author | Tuncel, Betül | |
dc.contributor.author | Özgenel, Güzin Yeşim | |
dc.contributor.buuauthor | ÖZGENEL, GÜZİN YEŞİM | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Plastik, Rekonstrüktif ve Estetik Cerrahi Anabilim Dalı. | |
dc.contributor.researcherid | AAH-4233-2021 | |
dc.date.accessioned | 2024-09-11T08:32:46Z | |
dc.date.available | 2024-09-11T08:32:46Z | |
dc.date.issued | 2018-01-01 | |
dc.description.abstract | Objective: This study investigated the effect of topical 5-fluorouracil (5-FU) application on the epineural scar tissue, which has a negative impact on the outcome after a peripheral nerve surgery, and whether the application of two doses of 5-FU would change the outcome.Materials and Methods: The study involved 72, 3-month-old female Sprague-Dawley rats weighing 250-300 g each. After the experimental animals were observed for a week to make certain that they were healthy, they were randomly divided into 3 main groups; Group A: skin incision + epineurotomy + isotonic solution (n=24), Group B: skin incision + epineurotomy + single dose of 5-FU (n=24) and Group C: skin incision + epineurotomy + two doses of 5-FU (n=24). Each group was divided into 2 subgroups based on the weeks in which they were examined. The two subgroups in each of the three groups were made subject to a walking test, and macroscopic and histopathological examinations at Week 4 and Week 8.Results: An evaluation of the macroscopic results showed that there was a statistically significant difference between Group A and Group C in sciatic nerve adhesion and severability of its branches. We obtained better results in Group C, when compared with the results obtained in Group A.Conclusion: We demonstrated in our study that 5-FU had a positive effect on the scar tissue developed around the epineurectomized nerve. This positive effect was also reflected in the nerve's functional capacity, and a second dose of 5-FU application further improved this effect. | |
dc.identifier.doi | 10.5472/marumj.342046 | |
dc.identifier.endpage | 10 | |
dc.identifier.issn | 1309-9469 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 1 | |
dc.identifier.uri | https://doi.org/10.5472/marumj.342046 | |
dc.identifier.uri | https://dergipark.org.tr/en/pub/marumj/issue/33298/342046 | |
dc.identifier.uri | https://hdl.handle.net/11452/44552 | |
dc.identifier.volume | 31 | |
dc.identifier.wos | 000430072000001 | |
dc.indexed.wos | WOS.ESCI | |
dc.language.iso | en | |
dc.publisher | Marmara Üniversitesi | |
dc.relation.journal | Marmara Medical Journal | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Walking-track analysis | |
dc.subject | Carpal-tunnel-syndrome | |
dc.subject | Mitomycin-c | |
dc.subject | Functional-evaluation | |
dc.subject | Tibial nerve | |
dc.subject | Fibroblasts | |
dc.subject | Subconjunctival | |
dc.subject | Regeneration | |
dc.subject | Fluorouracil | |
dc.subject | Exposures | |
dc.subject | Epineural scar tissue | |
dc.subject | 5-fluorouracil | |
dc.subject | Nerve adhesion | |
dc.subject | General & internal medicine | |
dc.title | The effect of topical 5-fluorouracil application on epineural scar tissue in epineurectomized rat sciatic nerve | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 3c738968-ecbd-4034-82f6-d3bc1da94b7a | |
relation.isAuthorOfPublication.latestForDiscovery | 3c738968-ecbd-4034-82f6-d3bc1da94b7a |
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