Publication:
Statistical shape analysis of putamen in early-onset Parkinson's disease

dc.contributor.authorSığırlı, Deniz
dc.contributor.authorÖzdemir, Senem Turan
dc.contributor.authorErer, Sevda
dc.contributor.authorŞahin, İbrahim
dc.contributor.authorErcan, İlker
dc.contributor.authorÖzpar, Rifat
dc.contributor.authorÖrün, Muhammet Okay
dc.contributor.authorHakyemez, Bahattin
dc.contributor.buuauthorSIĞIRLI, DENİZ
dc.contributor.buuauthorERER ÖZBEK, ÇİĞDEM SEVDA
dc.contributor.buuauthorERCAN, İLKER
dc.contributor.buuauthorÖZPAR, RİFAT
dc.contributor.buuauthorHAKYEMEZ, BAHATTİN
dc.contributor.buuauthorÖzdemir, Senem Turan
dc.contributor.buuauthorŞahin, İbrahim
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi
dc.contributor.orcid0000-0001-9031-3040
dc.contributor.orcid0000-0002-3425-0740
dc.contributor.orcid0000-0001-6649-9287
dc.contributor.researcheridAAA-7472-2021
dc.contributor.researcheridFPU-9468-2022
dc.contributor.researcheridDVY-9744-2022
dc.contributor.researcheridHII-7787-2022
dc.contributor.researcheridABF-2367-2020
dc.contributor.researcheridAAH-5062-2021
dc.contributor.researcheridAAI-2318-2021
dc.date.accessioned2024-06-24T13:25:06Z
dc.date.available2024-06-24T13:25:06Z
dc.date.issued2021-10
dc.description.abstractObjective: To investigate the shape differences in the putamen of early-onset Parkinson's patients compared with healthy controls and to assess and to assess sub-regional brain abnormalities. Methods: This study was conducted using the 3-T MRI scans of 23 early-onset Parkinson's patients and age and gender matched control subjects. Landmark coordinate data obtained and Procrustes analysis was used to compare mean shapes. The relationships between the centroid sizes of the left and right putamen, and the durations of disease examined using growth curve models. Results: While there was a significant difference between the right putamen shape of control and patient groups, there was not found a significant difference in terms of left putamen. Sub-regional analyses showed that for the right putamen, the most prominent deformations were localized in the middle-posterior putamen and minimal deformations were seen in the anterior putamen. Conclusion: Although they were not as pronounced as those in the right putamen, the deformations in the left putamen mimic the deformations in the right putamen which are found mainly in the middle-posterior putamen and at a lesser extend in the anterior putamen.
dc.identifier.doi10.1016/j.clineuro.2021.106936
dc.identifier.issn0303-8467
dc.identifier.issn1872-6968
dc.identifier.pubmed34530266
dc.identifier.urihttps://doi.org/10.1016/j.clineuro.2021.106936
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0303846721004650
dc.identifier.urihttps://hdl.handle.net/11452/42301
dc.identifier.volume209
dc.identifier.wos000704947800008
dc.indexed.pubmedPubMed
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherElsevier
dc.relation.journalClinical Neurology and Neurosurgery
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBasal ganglia
dc.subjectAlzheimers-disease
dc.subjectGray-matter
dc.subjectStriatum
dc.subjectVolume
dc.subjectThalamus
dc.subjectAtrophy
dc.subjectReward
dc.subjectBrain
dc.subjectAssociation
dc.subjectParkinson's disease
dc.subjectEarly-onset
dc.subjectPutamen
dc.subjectStatistical shape analysis
dc.subjectMagnetic resonance imaging
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectClinical neurology
dc.subjectSurgery
dc.subjectNeurosciences & neurology
dc.titleStatistical shape analysis of putamen in early-onset Parkinson's disease
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoveryf8b7b771-12ea-4f9a-889d-25079d8c862d

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