Publication:
Effect of locoregional treatments in hepatocellular carcinoma: What are the pathologic/radiologic Milan Criteria?

dc.contributor.authorAksoy, Fuat
dc.contributor.authorDündar, Halit Ziya
dc.contributor.authorÇelik, Fatih
dc.contributor.authorÖngen, Gökhan
dc.contributor.authorNas, Ömer Fatih
dc.contributor.authorSağlam, Kutay
dc.contributor.authorGürlüler, Ercüment
dc.contributor.authorKıyıcı, Murat
dc.contributor.authorKaya, Ekrem
dc.contributor.buuauthorAKSOY, FUAT
dc.contributor.buuauthorDÜNDAR, HALİT ZİYA
dc.contributor.buuauthorÇELİK, FATİH
dc.contributor.buuauthorÖNGEN, GÖKHAN
dc.contributor.buuauthorNAS, ÖMER FATİH
dc.contributor.buuauthorSAĞLAM, KUTAY
dc.contributor.buuauthorGÜRLÜLER, ERCÜMENT
dc.contributor.buuauthorKIYICI, MURAT
dc.contributor.buuauthorKAYA, EKREM
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Organ Nakli Merkezi.
dc.contributor.orcid0000-0001-5808-9384
dc.contributor.orcid0000-0003-2728-9521
dc.contributor.researcheridHII-8895-2022
dc.contributor.researcheridX-7425-2018
dc.contributor.researcheridEWI-3634-2022
dc.contributor.researcheridJYY-5340-2024
dc.contributor.researcheridFQR-8472-2022
dc.contributor.researcheridJJS-3965-2023
dc.contributor.researcheridJSD-3843-2023
dc.contributor.researcheridFHW-0015-2022
dc.contributor.researcheridJSF-3184-2023
dc.date.accessioned2024-10-07T12:50:26Z
dc.date.available2024-10-07T12:50:26Z
dc.date.issued2023-10-01
dc.description.abstractObjectives: Milan criteria is the most commonly used criteria for patients with hepatocellular carcinoma awaiting liver transplant. The effects of locoregional therapy on downstaging or bridging before liver transplant on survival remain controversial. Considering that the tumor size may change with locoregional therapy and formalin fixation after explantation, we aimed to evaluate the effects of locoregional therapy on radiological and pathological Milan criteria and survival.Materials and Methods: Demographic data, etiology, preoperative alpha-fetoprotein value, Child-Pugh and Model for End-Stage Liver Disease-Na scores, status of being inside or outside of radiological Milan criteria, status of being inside or outside of Milan criteria in explant (pathological Milan criteria), and the locoregional therapy types and combinations were evaluated for their effects on inclusion in Milan criteria and survival.Results: During the study period, 396 patients underwent liver transplant at our center, with 97 because of cirrhosis and hepatocellular carcinoma. When we viewed patients according to preoperative radiologic evaluations, 67.9% were within Milan criteria and 32.1% were outside. When we viewed according to explant (pathological) evaluations, 80.7% of patients were within Milan criteria. Among 97 patients, 71 (73.2%) had locoregional therapy (22 [30.9%] for downstaging, 49 [69.0%] for bridging to transplant), and 12 patients (12.3%) were within Milan criteria on explant examination while outside of Milan criteria before LT. One-year, 3-year, and 5-year survival rates were 80.7%, 76.1%, and 71.6%, respectively. Conclusions: As a result of radiological evaluations, in patients who were outside of Milan criteria and underwent locoregional therapy, explant pathology within Milan criteria had a positive effect on survival; however, after locoregional therapy, there was no significant effect on survival in patients who were still outside of Milan criteria.
dc.identifier.doi10.6002/ect.2023.0221
dc.identifier.endpage825
dc.identifier.issn1304-0855
dc.identifier.issue10
dc.identifier.startpage820
dc.identifier.urihttps://doi.org/10.6002/ect.2023.0221
dc.identifier.urihttps://www.ectrx.org/detail/archive/2023/21/10/0/820/0
dc.identifier.urihttps://hdl.handle.net/11452/45997
dc.identifier.volume21
dc.identifier.wos001101358600005
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherBaşkent Üniversitesi
dc.relation.journalExperimental and Clinical Transplantation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLiver-transplantation
dc.subjectRadiofrequency ablation
dc.subjectCandidates
dc.subjectSurvival
dc.subjectFixation
dc.subjectCancer
dc.subjectBridge
dc.subjectRisk
dc.subjectBridge to transplant
dc.subjectDownstaging
dc.subjectLocoregional therapy
dc.subjectTransplantation
dc.titleEffect of locoregional treatments in hepatocellular carcinoma: What are the pathologic/radiologic Milan Criteria?
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery9188647a-59b3-41bd-be73-594de198226a

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