Publication:
Focal segmental glomerulosclerosis: A single center experience

dc.contributor.authorAyar, Yavuz
dc.contributor.authorErsoy, Alparslan
dc.contributor.authorYıldız, Abdülmecit
dc.contributor.authorOruç, Ayşegül
dc.contributor.authorCan, Fatma Ezgi
dc.contributor.authorOcakoğlu, Gökhan
dc.contributor.authorGüllülü, Mustafa
dc.contributor.authorDemirayak, Dilay
dc.contributor.authorBayrakçı, İsmail
dc.contributor.authorDüger, Hakan
dc.contributor.authorOcak, Tuğba
dc.contributor.authorKorkut, Bayram
dc.contributor.authorŞahin, Ahmet Bilgehan
dc.contributor.authorAkan, Mustafa
dc.contributor.authorEylemer, Eda
dc.contributor.buuauthorAyar, Yavuz
dc.contributor.buuauthorERSOY, ALPARSLAN
dc.contributor.buuauthorYILDIZ, ABDULMECİT
dc.contributor.buuauthorORUÇ, AYŞEGÜL
dc.contributor.buuauthorCan, Fatma Ezgi
dc.contributor.buuauthorOCAKOĞLU, GÖKHAN
dc.contributor.buuauthorGÜLLÜLÜ, MUSTAFA
dc.contributor.buuauthorDemirayak, Dilay
dc.contributor.buuauthorBayrakçı, İsmail
dc.contributor.buuauthorDüger, Hakan
dc.contributor.buuauthorOCAK, TUĞBA
dc.contributor.buuauthorKorkut, Bayram
dc.contributor.buuauthorŞAHİN, AHMET BİLGEHAN
dc.contributor.buuauthorAkan, Mustafa
dc.contributor.buuauthorEylemer, Eda
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentİç Hastalıkları Ana Bilim Dalı
dc.contributor.orcid0000-0003-4607-9220
dc.contributor.orcid0000-0002-0342-9692
dc.contributor.orcid0000-0002-1114-6051
dc.contributor.orcid0000-0001-5926-6813
dc.contributor.orcid0000-0001-5478-3192
dc.contributor.orcid0000-0002-7846-0870
dc.contributor.orcid0000-0002-9252-8341
dc.contributor.orcid0000-0002-0710-0923
dc.contributor.orcid0000-0002-1953-7735
dc.contributor.researcheridAGF-0767-2022
dc.contributor.researcheridAAH-5054-2021
dc.contributor.researcheridHIG-9032-2022
dc.contributor.researcheridAAH-4002-2021
dc.contributor.researcheridJSL-7718-2023
dc.contributor.researcheridHLG-6346-2023
dc.contributor.researcheridJGS-9425-2023
dc.contributor.researcheridEQO-1344-2022
dc.contributor.researcheridJLB-1564-2023
dc.contributor.researcheridIZP-9361-2023
dc.contributor.researcheridFPM-3131-2022
dc.contributor.researcheridFFH-4157-2022
dc.contributor.researcheridAAM-4927-2020
dc.contributor.researcheridKUI-8062-2024
dc.contributor.researcheridCOF-1782-2022
dc.date.accessioned2024-10-22T06:34:00Z
dc.date.available2024-10-22T06:34:00Z
dc.date.issued2016-09-01
dc.description.abstractAim: Focal segmental glomerulosclerosis (FSGS) is one of the most common glomerulonephritis (GNP) worldwide. Despite treatment, it may progress to end-stage renal disease. In the present study, we compared clinical and histopathological data on FSGS with primary and secondary GNP retrospectively.Methods: We retrospectively analyzed data on clinical and laboratory findings, treatment response, and risk factors associated with mortality in patients, who had been diagnosed with FSGS and other GNP via renal biopsy between January 2009 and December 2014. The average follow-up time was 22 (8-76) months.Results: FSGS and primary GNP were more frequently seen in males than in females (55.9% vs. 65.3%, p=0.033). Nephrotic syndrome was more common in patients with FSGS (41.2%) and primary GNP (57.7%), while chronic renal disease was more frequent in patients with secondary GNP (35%). In FSGS, the complete remission rate was 54.4%. 63.2% of patients had continued to receive treatment. According to the biopsy findings, interstitial inflammation and fibrosis were observed in 100% and 98.5% of patients with FSGS, respectively (p=0.010 and p<0.001, respectively). Serum albumin level was found to be increased and proteinuria, total cholesterol, triglyceride, and LDL levels to be decreased after treatment (p<0.001). Serum creatinine levels and type of GNP (secondary GNP) were detected to be 1.48 and 8.14 fold increased in mortality analysis, respectively.Conclusion: Renal biopsy is the gold standard for the diagnosis of glomerular diseases. Renal function at the time of diagnosis, follow-up and appropriate immunosuppressive therapy have effects on mortality and clinical progress in FSGS as is the case in all GNPs.
dc.identifier.doi10.4274/haseki.2941
dc.identifier.endpage143
dc.identifier.issn1302-0072
dc.identifier.issue3
dc.identifier.startpage137
dc.identifier.urihttps://doi.org/10.4274/haseki.2941
dc.identifier.urihttps://hasekidergisi.com/articles/doi/haseki.2941
dc.identifier.urihttps://hdl.handle.net/11452/46828
dc.identifier.volume54
dc.identifier.wos000391198800003
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherGalenos Yayıncılık
dc.relation.journalHaseki Tıp Bülteni-Medical Bulletin of Haseki
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGlomerular-diseases
dc.subjectGlomerulonephritis
dc.subjectProteinuria
dc.subjectFocal segmental glomerulosclerosis
dc.subjectGlomerulonephritis
dc.subjectProteinuria
dc.subjectRenal biopsy
dc.subjectGeneral & internal medicine
dc.titleFocal segmental glomerulosclerosis: A single center experience
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Nefroloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Biyoistatistik Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/İç Hastalıkları Ana Bilim Dalı
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