Publication:
Examination of the development and asymmetry of the cerebellum and its lobules in individuals aged 1-18 years: A retrospective mri study

dc.contributor.buuauthorIŞIKLAR, SEFA
dc.contributor.buuauthorDemir, İmren
dc.contributor.buuauthorDEMİR AKKUŞ, İMREN
dc.contributor.buuauthorÖzdemir, Senem Turan
dc.contributor.buuauthorÖzpar, Rıfat
dc.contributor.buuauthorÖZPAR, RİFAT
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloj Anabilim Dalı.
dc.contributor.orcid0000-0002-2070-5193
dc.contributor.orcid0000-0001-6649-9287
dc.contributor.researcheridAAK-3779-2021
dc.contributor.researcheridJCN-7254-2023
dc.date.accessioned2024-10-03T11:51:30Z
dc.date.available2024-10-03T11:51:30Z
dc.date.issued2023-08-08
dc.description.abstractDevelopmental studies of cerebellar lobules were limited. To our knowledge, structural asymmetry has not been studied in immature cerebellar lobules in the 1-18 age group. This study investigated the effect of age and gender on the volumetric development and asymmetry of the global cerebellum and cerebellar lobules in children and adolescents. In this retrospective study, we included 670 individuals [376 (56.1%) males] aged 1-18 years with normal brain MRIs between 2012 and 2021. volBrain CERES automatically segmented the right and left sides of the cerebellar lobules on three-dimensional T1-weighted MRIs. Volume and asymmetry data from individuals in 16 different age ranges were compared with SPSS (ver.28). The absolute volumetric development of the total cerebellum was consistent with the "S" development model in both sexes. The developmental trajectories of the cerebellar lobules were different from each other and showed sexual dimorphism. In the 1-18 age group, the absolute volumes of the total cerebellum and cerebellar lobules were significantly greater in males (p < 0.05). Absolute volumes of lobules IV, VIIB, VIIIA and VIIIB in the age groups had more gender differences. However, sexual dimorphism was insignificant in the cerebellum's total and lobular relative volume. Lobules IV, V, VI, VIIIA and VIIIB had left > right asymmetry and other lobules and total cerebellum had right > left asymmetry. This study confirmed the developmental heterogeneity and sexual dimorphism in the cerebellar lobules. It also provided volumetric data of the immature cerebellum to enable comparison in various neurological and neuropsychiatric diseases.
dc.identifier.doi10.1007/s10548-023-00997-2
dc.identifier.endpage925
dc.identifier.issn0896-0267
dc.identifier.issue6
dc.identifier.startpage901
dc.identifier.urihttps://doi.org/10.1007/s10548-023-00997-2
dc.identifier.urihttps://hdl.handle.net/11452/45803
dc.identifier.volume36
dc.identifier.wos001043649600001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer
dc.relation.journalBrain Topography
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.subjectHuman brain-development
dc.subjectVolume reduction
dc.subjectSex-differences
dc.subjectChildren
dc.subjectSegmentation
dc.subjectMetaanalysis
dc.subjectAdolescence
dc.subjectCerebellum
dc.subjectDevelopment
dc.subjectPaediatrics
dc.subjectVolume
dc.subjectAsymmetry
dc.subjectMri
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectClinical neurology
dc.subjectNeurosciences
dc.subjectNeurosciences & neurology
dc.titleExamination of the development and asymmetry of the cerebellum and its lobules in individuals aged 1-18 years: A retrospective mri study
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication8183356b-fb17-47f9-86d8-9566fdeb85ab
relation.isAuthorOfPublicationdc3d8b26-28ff-4873-afe7-20a4e670fa03
relation.isAuthorOfPublication597eca82-1312-4286-b1b1-b47aec03619c
relation.isAuthorOfPublication.latestForDiscovery8183356b-fb17-47f9-86d8-9566fdeb85ab

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