Publication:
Spectral domain optical coherence tomography findings in Turkish sickle-cell disease and beta thalassemia major patients

dc.contributor.authorUlusoy, Mahmut Oğuz
dc.contributor.authorTürk, Hakan
dc.contributor.authorKıvanç, Sertaç Argun
dc.contributor.buuauthorKIVANÇ, SERTAÇ ARGUN
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı
dc.contributor.researcheridAAH-6518-2021
dc.date.accessioned2024-07-22T06:22:05Z
dc.date.available2024-07-22T06:22:05Z
dc.date.issued2019-09-01
dc.description.abstractPurpose: To assess probable structural changes using spectral domain optical coherence tomography (SD-OCT) on sickle-cell disease (SCD) and beta thalassemia major (B-TM) patients, without any retinal abnormalities.Methods: This cross-sectional study included 32 B-TM, 34 SCD patients, and 44 healthy controls. One of the eyes of all participants was evaluated for SD-OCT and choroidal thickness, retinal nerve fiber layer (RNFL) thickness, central macular thickness (CMT), ganglion cell complex (GCC).Results: Age, gender, and intraocular pressure (IOP) were not statistically different between the three groups. Hemoglobin (Hgb), hematocrite (Htc), and ferritin levels were not statistically different between the SCD and B-TM groups. Choroidal thickness at the subfoveal region was statistically higher in the control group (353.79 +/- 71.93) than in the B-TM (317.41 +/- 53.44) and SCD (283.21 +/- 63.27) groups. In addition, it was statistically higher in the B-TM group than the SCD group (P = 0.05). CMT did not differ among the three groups, average RNFL was only significantly thinner in SCD than in controls, and GCC thickness was significantly thinner in SCD than in controls and B-TM.Conclusion: In both diseases, we can show early structural changes even if proliferative or non-proliferative retinopathy or other ocular manifestations were not developed yet. Copyright (C) 2019, Iranian Society of Ophthalmology. Production and hosting by Elsevier B.V.
dc.identifier.doi10.1016/j.joco.2019.01.012
dc.identifier.endpage280
dc.identifier.issn2452-2325
dc.identifier.issue3
dc.identifier.startpage275
dc.identifier.urihttps://doi.org/10.1016/j.joco.2019.01.012
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2452232518303007
dc.identifier.urihttps://europepmc.org/backend/ptpmcrender.fcgi
dc.identifier.urihttps://hdl.handle.net/11452/43354
dc.identifier.volume31
dc.identifier.wos000485175300005
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.journalJournal of Current Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFiber layer thickness
dc.subjectChoroidal thickness
dc.subjectOcular manifestations
dc.subjectChildren
dc.subjectBeta thalassemia major
dc.subjectChoroidal thickness
dc.subjectSickle-cell disease
dc.subjectSpectral domain optical coherence tomography
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectOphthalmology
dc.titleSpectral domain optical coherence tomography findings in Turkish sickle-cell disease and beta thalassemia major patients
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationc34828fa-eda6-42fd-a25f-67d0b219d1bb
relation.isAuthorOfPublication.latestForDiscoveryc34828fa-eda6-42fd-a25f-67d0b219d1bb

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