Publication:
Tadalafil against hyperoxia-induced oxidative stress; an experimental study

dc.contributor.authorDemir, Aslan
dc.contributor.authorKılıçarslan, Nermin
dc.contributor.buuauthorYENİ, SEZGİN
dc.contributor.buuauthorÇiçek, Mehmet Çağatay
dc.contributor.buuauthorÇİÇEK, MEHMET ÇAĞATAY
dc.contributor.buuauthorSarıçetin, Aysun
dc.contributor.buuauthorDirican, Melahat
dc.contributor.buuauthorErtan, Erol
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.
dc.contributor.orcid0000-0001-5143-6507
dc.contributor.orcid0000-0002-5855-9099
dc.contributor.orcid0000-0002-0471-5404
dc.date.accessioned2024-10-09T05:51:37Z
dc.date.available2024-10-09T05:51:37Z
dc.date.issued2022-06-08
dc.description.abstractThis study aimed to investigate the protective effect of tadalafil on reactive oxygen species induced by a hyperoxia model in rats, both in terms of enzymes such as superoxide dismutase (SOD) and nitric oxide (NO), and its pathological effects on the corpus cavernosum. Overall, 24 rats were divided into three groups. The control group (eight rats) was not exposed to any intervention. The second group (eight rats), was exposed to hyperoxia in a hyperoxia cabinet for 8 h a day for 10 days. The third group (eight rats) was exposed to hyperoxia the same as in the second group, tadalafil at a dose of 10 mg/kg was given orally as a dissolved form in water in the amount of 10-12 ml/100 g/day to the rats placed in separate cages having removed from the hyperoxia cabin. SOD levels differ enough to create a difference, but there was no significant difference in terms of NO levels. The SOD level was highest in hyperoxia conditions and lowest in the group given tadalafil. While corpus cavernosum hyperemia was found to be higher statistically in the experimental groups than in the control group, we found that the severity of hyperemia was less in the group given tadalafil. The corpus cavernosum was found to be statistically more dilated in the experimental groups than in the control group. We determined that hyperoxia status increased the level of SOD and this level decreased with tadalafil administration, which would make a statistical difference.
dc.identifier.doi10.1111/and.14494
dc.identifier.issn0303-4569
dc.identifier.urihttps://doi.org/10.1111/and.14494
dc.identifier.urihttps://hdl.handle.net/11452/46109
dc.identifier.wos000807726900001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWiley
dc.relation.journalAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFree-radicals
dc.subjectErectile dysfunction
dc.subjectAntioxidants
dc.subjectAntioxidants
dc.subjectErectile dysfunction
dc.subjectTadalafil
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectAndrology
dc.subjectEndocrinology & metabolism
dc.titleTadalafil against hyperoxia-induced oxidative stress; an experimental study
dc.typeArticle
dc.typeEarly Access
dspace.entity.typePublication
relation.isAuthorOfPublication27ed7a6c-fea4-4bfd-8cde-4506947b3fe8
relation.isAuthorOfPublication7c4a68a5-1acc-4fc7-877a-59b23dc62d26
relation.isAuthorOfPublication.latestForDiscovery27ed7a6c-fea4-4bfd-8cde-4506947b3fe8

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