Publication: Tarantula cubensis extract (Theranekron®) inhibits inflammation in carrageenan-induced acute paw edema in rats
dc.contributor.author | İpek, Volkan | |
dc.contributor.buuauthor | Özfırat, E. C. | |
dc.contributor.buuauthor | ÖZFIRAT, NEVZAT | |
dc.contributor.buuauthor | Topal, A. | |
dc.contributor.buuauthor | Satar, N. Y. G. | |
dc.contributor.buuauthor | GÜL SATAR, NİHAL YAŞAR | |
dc.contributor.buuauthor | Pamukçular, O. | |
dc.contributor.buuauthor | Uçkan, E. M. | |
dc.contributor.buuauthor | Akkoç A. | |
dc.contributor.buuauthor | AKKOÇ, AHMET | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Veteriner Fakültesi | |
dc.contributor.orcid | 0000-0002-5090-7917 | |
dc.contributor.orcid | 0000-0001-5874-7797 | |
dc.date.accessioned | 2024-09-13T05:48:23Z | |
dc.date.available | 2024-09-13T05:48:23Z | |
dc.date.issued | 2022-01-01 | |
dc.description.abstract | The aim of this study was to investigate the anti-inflammatory effect of alcoholic extract of Tarantula cubensis alcoholic extract (TCAE) in experimentally induced inflammation in rats. Fifty-four adult Sprague-Dawley male rats were randomly divided into nine groups. Paw edema was induced by 0.2mL subplantar (s.p.) injection of 1% carrageenan (CAR) into the right hind paw. Rats were treated with the nonsteroidal anti-inflammatory drug (NSAID) indomethacin (INDO) (10mg/kg, p.o.) or TCAE at different doses (1, 10 or 100 mu g/kg) injected s.c. for systemic or s.p. for local anti-inflammatory effect. Saline was used as control. Changes in paw thickness, volume, and weight were calculated as percentages. Formalin-fixed paws were used for histopathological examination. We detected that TCAE applied s.c. at 10 mu g/kg and 100 mu g/kg doses resulted in thinner paw thickness, lower paw volume, and lower paw weights four hours after the induction of inflammation when compared with the INDO group (p<0.05). The paw edema inhibitory effect of TCAE applied at a dose of 10 mu g/kg, s.c. was 68% when compared with the INDO which had an inhibitory effect of 56%. These results were verified with similar histopathological findings. The anti-inflammatory feature of 10 mu g/kg of TCAE given systematically was similar to the effects of INDO. Our results suggest that TCAE has anti-inflammatory effects by reducing edema and decreasing inflammatory reaction. These results may be attributed to the inhibition of the production of proinflammatory mediators. Thus, TCAE may be considered as a potential anti-inflammatory agent for treating acute inflammatory conditions. | |
dc.identifier.doi | 10.1590/1678-4162-12550 | |
dc.identifier.endpage | 64 | |
dc.identifier.issn | 0102-0935 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 56 | |
dc.identifier.uri | https://doi.org/10.1590/1678-4162-12550 | |
dc.identifier.uri | https://hdl.handle.net/11452/44684 | |
dc.identifier.volume | 74 | |
dc.identifier.wos | 000791588100007 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Arquivo Brasileiro Medicina Veterinaria Zootecnia | |
dc.relation.journal | Arquivo Brasileiro De Medicina Veterinaria E Zootecnia | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Efficacy | |
dc.subject | Cattle | |
dc.subject | Trial | |
dc.subject | Venom | |
dc.subject | Inflammation | |
dc.subject | Paw edema | |
dc.subject | Rat | |
dc.subject | Tarantula cubensis | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Veterinary sciences | |
dc.title | Tarantula cubensis extract (Theranekron®) inhibits inflammation in carrageenan-induced acute paw edema in rats | |
dc.type | Article | |
dspace.entity.type | Publication | |
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relation.isAuthorOfPublication.latestForDiscovery | 0da63533-977a-4d63-8bbe-3914e673a1bd |