Publication:
Tarantula cubensis extract (Theranekron®) inhibits inflammation in carrageenan-induced acute paw edema in rats

dc.contributor.authorİpek, Volkan
dc.contributor.buuauthorÖzfırat, E. C.
dc.contributor.buuauthorÖZFIRAT, NEVZAT
dc.contributor.buuauthorTopal, A.
dc.contributor.buuauthorSatar, N. Y. G.
dc.contributor.buuauthorGÜL SATAR, NİHAL YAŞAR
dc.contributor.buuauthorPamukçular, O.
dc.contributor.buuauthorUçkan, E. M.
dc.contributor.buuauthorAkkoç A.
dc.contributor.buuauthorAKKOÇ, AHMET
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi
dc.contributor.orcid0000-0002-5090-7917
dc.contributor.orcid0000-0001-5874-7797
dc.date.accessioned2024-09-13T05:48:23Z
dc.date.available2024-09-13T05:48:23Z
dc.date.issued2022-01-01
dc.description.abstractThe aim of this study was to investigate the anti-inflammatory effect of alcoholic extract of Tarantula cubensis alcoholic extract (TCAE) in experimentally induced inflammation in rats. Fifty-four adult Sprague-Dawley male rats were randomly divided into nine groups. Paw edema was induced by 0.2mL subplantar (s.p.) injection of 1% carrageenan (CAR) into the right hind paw. Rats were treated with the nonsteroidal anti-inflammatory drug (NSAID) indomethacin (INDO) (10mg/kg, p.o.) or TCAE at different doses (1, 10 or 100 mu g/kg) injected s.c. for systemic or s.p. for local anti-inflammatory effect. Saline was used as control. Changes in paw thickness, volume, and weight were calculated as percentages. Formalin-fixed paws were used for histopathological examination. We detected that TCAE applied s.c. at 10 mu g/kg and 100 mu g/kg doses resulted in thinner paw thickness, lower paw volume, and lower paw weights four hours after the induction of inflammation when compared with the INDO group (p<0.05). The paw edema inhibitory effect of TCAE applied at a dose of 10 mu g/kg, s.c. was 68% when compared with the INDO which had an inhibitory effect of 56%. These results were verified with similar histopathological findings. The anti-inflammatory feature of 10 mu g/kg of TCAE given systematically was similar to the effects of INDO. Our results suggest that TCAE has anti-inflammatory effects by reducing edema and decreasing inflammatory reaction. These results may be attributed to the inhibition of the production of proinflammatory mediators. Thus, TCAE may be considered as a potential anti-inflammatory agent for treating acute inflammatory conditions.
dc.identifier.doi10.1590/1678-4162-12550
dc.identifier.endpage64
dc.identifier.issn0102-0935
dc.identifier.issue1
dc.identifier.startpage56
dc.identifier.urihttps://doi.org/10.1590/1678-4162-12550
dc.identifier.urihttps://hdl.handle.net/11452/44684
dc.identifier.volume74
dc.identifier.wos000791588100007
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherArquivo Brasileiro Medicina Veterinaria Zootecnia
dc.relation.journalArquivo Brasileiro De Medicina Veterinaria E Zootecnia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEfficacy
dc.subjectCattle
dc.subjectTrial
dc.subjectVenom
dc.subjectInflammation
dc.subjectPaw edema
dc.subjectRat
dc.subjectTarantula cubensis
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectVeterinary sciences
dc.titleTarantula cubensis extract (Theranekron®) inhibits inflammation in carrageenan-induced acute paw edema in rats
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication0da63533-977a-4d63-8bbe-3914e673a1bd
relation.isAuthorOfPublication2b229b19-2fb1-47e0-9752-4c82ad01fcb8
relation.isAuthorOfPublication77d6f8ff-e2a2-45b4-a991-48f59fee43a4
relation.isAuthorOfPublication.latestForDiscovery0da63533-977a-4d63-8bbe-3914e673a1bd

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