Publication:
Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing

dc.contributor.authorBağdaş, Deniz
dc.contributor.authorGül, Nihal Yaşar
dc.contributor.authorTopal, Ayşe
dc.contributor.authorTaş, Sibel
dc.contributor.authorÖzyiğit, Musa Özgür
dc.contributor.authorCinkIlıç, NilÜfer
dc.contributor.authorGül, Zülfiye
dc.contributor.authorEtoz, Betül Cam
dc.contributor.authorZiyanok, Sedef
dc.contributor.authorİnan, Sevda
dc.contributor.authorTuracozen, Özge
dc.contributor.authorGürün, Mine Sibel
dc.contributor.buuauthorBağdaş, Deniz
dc.contributor.buuauthorGÜL SATAR, NİHAL YAŞAR
dc.contributor.buuauthorTOPAL, AYŞE
dc.contributor.buuauthorTAŞ, SİBEL
dc.contributor.buuauthorÖZYİĞİT, MUSA ÖZGÜR
dc.contributor.buuauthorCinkIlıç, Nilüfer
dc.contributor.buuauthorGül, Zülfiye
dc.contributor.buuauthorEtoz, Betül Cam
dc.contributor.buuauthorZİYANOK DEMİRTAŞ, SEDEF
dc.contributor.buuauthorİnan, Sevda
dc.contributor.buuauthorTuracözen, Özge
dc.contributor.buuauthorGÜRÜN, MİNE SİBEL
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi
dc.contributor.departmentUludağ Üniversitesi Veteriner Fakültesi, Cerrahi Anabilim Dalı
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı
dc.contributor.orcid0000-0001-6225-774X
dc.contributor.orcid0000-0002-3595-6286
dc.contributor.orcid0000-0002-8872-0074
dc.contributor.orcid0000-0003-3878-3808
dc.contributor.orcid0000-0001-8138-5851
dc.contributor.researcheridAAG-8716-2019
dc.contributor.researcheridAAH-4272-2021
dc.contributor.researcheridAAF-9939-2020
dc.contributor.researcheridABE-6873-2020
dc.contributor.researcheridJBJ-7162-2023
dc.contributor.researcheridAAH-5296-2021
dc.contributor.researcheridAAR-6478-2021
dc.contributor.researcheridAAH-2873-2021
dc.contributor.researcheridE-3364-2018
dc.contributor.researcheridEOB-5882-2022
dc.contributor.researcheridGGO-6894-2022
dc.contributor.researcheridAAH-5296-2021
dc.date.accessioned2024-08-15T09:59:39Z
dc.date.available2024-08-15T09:59:39Z
dc.date.issued2014-11-01
dc.description.abstractChlorogenic acid (CGA) is a well-known natural antioxidant in human diet. To understand the effects of CGA on wound healing by enhancing antioxidant defense in the body, the present study sought to investigate the potential role of systemic CGA therapy on wound healing and oxidative stress markers of the skin. We also aimed to understand whether chronic CGA treatment has side effects on pivotal organs or rat bone marrow during therapy. Full-thickness experimental wounds were created on the backs of rats. CGA (25, 50, 100, 200 mg/kg) or vehicle was administered intraperitoneally for 15 days. All rats were sacrificed on the 16th day. Biochemical, histopathological, and immunohistochemical examinations were performed. Possible side effects were also investigated. The results suggested that CGA accelerated wound healing in a dose-dependent manner. CGA enhanced hydroxyproline content, decreased malondialdehyde and nitric oxide levels. and elevated reduced glutathione, superoxide dismutase, and catalase levels in wound tissues. Epithelialization, angiogenesis, fibroblast proliferation, and collagen formation increased by CGA while polymorph nuclear leukocytes infiltration decreased. CGA modulated matrix metalloproteinase-9 and tissue inhibitor-2 expression in biopsies. Otherwise, high dose of CGA increased lipid peroxidation of liver and kidney without affecting the heart and muscle samples. Chronic CGA increased micronuclei formation and induced cytotoxicity in the bone marrow. In conclusion, systemic CGA has beneficial effects in improving wound repair. Antioxidant, free radical scavenger, angiogenesis, and anti-inflammatory effects of CGA may ameliorate wound healing. High dose of CGA may induce side effects. In light of these observations, CGA supplementation or dietary CGA may have benefit on wound healing.
dc.identifier.doi10.1007/s00210-014-1034-9
dc.identifier.eissn1432-1912
dc.identifier.endpage1116
dc.identifier.issn0028-1298
dc.identifier.issue11
dc.identifier.startpage1101
dc.identifier.urihttps://doi.org/10.1007/s00210-014-1034-9
dc.identifier.urihttps://link.springer.com/article/10.1007/s00210-014-1034-9
dc.identifier.urihttps://hdl.handle.net/11452/44056
dc.identifier.volume387
dc.identifier.wos000344166500010
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer
dc.relation.bapKUAP (T) 2012/37
dc.relation.bapHDP (T) 2012/33
dc.relation.journalNaunyn-schmiedebergs Archives of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCaffeic acid
dc.subjectNitric-oxide
dc.subjectMatrix metalloproteinases
dc.subjectDifferential expression
dc.subjectProoxidant activities
dc.subjectTopical application
dc.subjectOxidative stress
dc.subjectPhenethyl ester
dc.subjectInstant coffee
dc.subjectDna-damage
dc.subjectAntioxidant
dc.subjectChlorogenic acid
dc.subjectHydroxyproline
dc.subjectMatrix metalloproteinase-9
dc.subjectTissue inhibitor-2
dc.subjectWound
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectPharmacology & pharmacy
dc.titlePharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery2b229b19-2fb1-47e0-9752-4c82ad01fcb8

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