Publication:
The importance of hemosiderin deposition in the infant brain: An autopsy study

dc.contributor.authorİnanır, Türkmen N.
dc.contributor.authorEren, F.
dc.contributor.authorAkgöz, S.
dc.contributor.authorEren, B.
dc.contributor.authorÇetin, S.
dc.contributor.authorGündoğmuş, U. N.
dc.contributor.authorÇomunoğlu, N.
dc.contributor.authorÇomunoğlu, C.
dc.contributor.buuauthorTÜRKMEN İNANIR, NURSEL
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.
dc.contributor.researcheridACP-5545-2022
dc.date.accessioned2024-08-08T11:54:37Z
dc.date.available2024-08-08T11:54:37Z
dc.date.issued2015-01-01
dc.description.abstractBackground/aim: Iron is an essential element involved in many metabolic processes. Presence and accumulation of iron in various body systems can result in different outcomes. Its accumulation in the central nervous system (CNS) cannot be detected routinely by application of hematoxylin-eosin staining. Detection of the presence of hemosiderin in the brain and cerebellum by application of Perls' dye is of importance in cases of infant deaths.Material and Methods: In this study, brain and cerebellar specimens obtained from 52 eligible infants (aged 0-1 years) autopsied in our institute between the years 2010 and 2013, independent of the cause of death, were analyzed in order to detect possible presence of hemosiderin. Perls' dye was used to detect histopathological staining intensity and distribution of hemosiderin in the brain and cerebellum.Results: Cases did not differ significantly as for the patients' age and gender (p = 0.473), type of the culprit trauma (p = 0.414), death/crime scene (p = 0.587), and diagnosis groups (p = 0.550). In this autopsy study blue colored hemosiderin granulations, stained with Perls' dye were detected in the brain (n: 39, 75%), and cerebellum (n: 35, 67.3%). A weakly negative, but significant correlation was detected between the postmortem interval and intensity values of cerebellar hemosiderin (Spearman's correlation coefficient: -0.381, p = 0.024). A statistically significant difference was found between the distribution scores of cerebral hemosiderin in cases with and without trauma history (p = 0.03). Median cerebral hemosiderin distribution scores were 2.5 and 2, respectively.Conclusions: The detection of a correlation between the presence of cerebral and cerebellar hemosiderin, and post-mortem interval in the age group of 0-1 years, should be interpreted as an important finding in the analysis of cerebral iron. The presence of hemosiderin in the CNS may be a significant finding in the elucidation of infant deaths and this procedure should be carried out on a routine basis.
dc.identifier.endpage171
dc.identifier.issn1108-4189
dc.identifier.issue2
dc.identifier.startpage164
dc.identifier.urihttps://hdl.handle.net/11452/43821
dc.identifier.volume19
dc.identifier.wos000367154400012
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherLithographia
dc.relation.journalHippokratia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIron accumulation
dc.subjectNeurodegeneration
dc.subjectDeficiency
dc.subjectHippocampus
dc.subjectHomeostasis
dc.subjectHemorrhage
dc.subjectFerritin
dc.subjectFetal
dc.subjectRat
dc.subjectBrain
dc.subjectHemosiderin
dc.subjectInfant
dc.subjectAutopsy
dc.subjectGeneral & internal medicine
dc.titleThe importance of hemosiderin deposition in the infant brain: An autopsy study
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationb47dba7f-e6a6-4844-a4de-3d51ee5a82c4
relation.isAuthorOfPublication.latestForDiscoveryb47dba7f-e6a6-4844-a4de-3d51ee5a82c4

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