Publication: Peritumoral and intratumoral lymphocytic infiltration and stromal reaction in high-risk endometrioid carcinomas
dc.contributor.buuauthor | Özsen, Mine | |
dc.contributor.buuauthor | ÖZŞEN, MİNE | |
dc.contributor.buuauthor | Atalay, Fatma Öz | |
dc.contributor.buuauthor | ÖZ ATALAY, FATMA | |
dc.contributor.buuauthor | OCAK, BİROL | |
dc.contributor.buuauthor | Hasdemir, Seçil | |
dc.contributor.buuauthor | HASDEMİR, SEÇİL | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı. | |
dc.contributor.orcid | 0000-0002-7188-6115 | |
dc.contributor.researcherid | AEC-2238-2022 | |
dc.date.accessioned | 2024-11-04T11:05:29Z | |
dc.date.available | 2024-11-04T11:05:29Z | |
dc.date.issued | 2023-01-01 | |
dc.description.abstract | Objective: This study aims to evaluate the relationship between the local immune response such as peritumoral and intratumoral lymphocytic infiltration and stromal reaction, with prognosis and other clinicopathological parameters in high-risk endometrioid carcinomas.Method: Totally 98 high-risk cases diagnosed as endometrioid carcinoma in our center between 2005 and 2017, were retrieved from the pathology archives and re-evaluated.Results: Totally 98 cases diagnosed as high-risk endometrial carcinoma were evaluated. Intratumoral and peritumoral lymphocytic infiltration was compared to overall survival period and overall survival was significantly higher in tumors showing peritumoral and intratumoral lymphocytic infiltration (p=0.000 <alpha=0.05, p=0.008 <alpha =0.05). However, a similar relationship between stromal reaction and overall survival rate was not detected. Intratumoral and peritumoral lymphocytic infiltration was compared to recurrence-free survival and recurrence-free survival period was significantly higher in cases showing either type of lymphocytic infiltration (p=0.003 <alpha =0.05, p=0.050 <alpha=0.05).Conclusions: Presence of peritumoral and intratumoral lymphocytic infiltration positively affects prognosis, similar to results of other studies. These parameters are important and necessary in predicting the prognosis of the patients and they should be included in pathology reports. | |
dc.identifier.doi | 10.12996/gmj.2023.31 | |
dc.identifier.endpage | 154 | |
dc.identifier.issn | 2147-2092 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 150 | |
dc.identifier.uri | https://doi.org/10.12996/gmj.2023.31 | |
dc.identifier.uri | https://hdl.handle.net/11452/47390 | |
dc.identifier.volume | 34 | |
dc.identifier.wos | 000957627000005 | |
dc.indexed.wos | WOS.ESCI | |
dc.language.iso | en | |
dc.publisher | Gazi Univ, Fac Med | |
dc.relation.journal | Gazi Medical Journal | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Prognostic-significance | |
dc.subject | Cancer | |
dc.subject | Adenocarcinoma | |
dc.subject | Mutations | |
dc.subject | Survival | |
dc.subject | Endometrioid carcinoma | |
dc.subject | Intratumoral | |
dc.subject | High grade | |
dc.subject | Lymphocytic infiltration | |
dc.subject | Peritumoral | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Medicine, general & internal | |
dc.subject | General & internal medicine | |
dc.title | Peritumoral and intratumoral lymphocytic infiltration and stromal reaction in high-risk endometrioid carcinomas | |
dc.type | Article | |
dspace.entity.type | Publication | |
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relation.isAuthorOfPublication | 5e129638-8221-4fc2-8956-7c31d3fea07b | |
relation.isAuthorOfPublication.latestForDiscovery | 736328be-f008-46e1-825a-46199f11dad9 |