Publication:
Peritumoral and intratumoral lymphocytic infiltration and stromal reaction in high-risk endometrioid carcinomas

dc.contributor.buuauthorÖzsen, Mine
dc.contributor.buuauthorÖZŞEN, MİNE
dc.contributor.buuauthorAtalay, Fatma Öz
dc.contributor.buuauthorÖZ ATALAY, FATMA
dc.contributor.buuauthorOCAK, BİROL
dc.contributor.buuauthorHasdemir, Seçil
dc.contributor.buuauthorHASDEMİR, SEÇİL
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.
dc.contributor.orcid0000-0002-7188-6115
dc.contributor.researcheridAEC-2238-2022
dc.date.accessioned2024-11-04T11:05:29Z
dc.date.available2024-11-04T11:05:29Z
dc.date.issued2023-01-01
dc.description.abstractObjective: This study aims to evaluate the relationship between the local immune response such as peritumoral and intratumoral lymphocytic infiltration and stromal reaction, with prognosis and other clinicopathological parameters in high-risk endometrioid carcinomas.Method: Totally 98 high-risk cases diagnosed as endometrioid carcinoma in our center between 2005 and 2017, were retrieved from the pathology archives and re-evaluated.Results: Totally 98 cases diagnosed as high-risk endometrial carcinoma were evaluated. Intratumoral and peritumoral lymphocytic infiltration was compared to overall survival period and overall survival was significantly higher in tumors showing peritumoral and intratumoral lymphocytic infiltration (p=0.000 <alpha=0.05, p=0.008 <alpha =0.05). However, a similar relationship between stromal reaction and overall survival rate was not detected. Intratumoral and peritumoral lymphocytic infiltration was compared to recurrence-free survival and recurrence-free survival period was significantly higher in cases showing either type of lymphocytic infiltration (p=0.003 <alpha =0.05, p=0.050 <alpha=0.05).Conclusions: Presence of peritumoral and intratumoral lymphocytic infiltration positively affects prognosis, similar to results of other studies. These parameters are important and necessary in predicting the prognosis of the patients and they should be included in pathology reports.
dc.identifier.doi10.12996/gmj.2023.31
dc.identifier.endpage154
dc.identifier.issn2147-2092
dc.identifier.issue2
dc.identifier.startpage150
dc.identifier.urihttps://doi.org/10.12996/gmj.2023.31
dc.identifier.urihttps://hdl.handle.net/11452/47390
dc.identifier.volume34
dc.identifier.wos000957627000005
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherGazi Univ, Fac Med
dc.relation.journalGazi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPrognostic-significance
dc.subjectCancer
dc.subjectAdenocarcinoma
dc.subjectMutations
dc.subjectSurvival
dc.subjectEndometrioid carcinoma
dc.subjectIntratumoral
dc.subjectHigh grade
dc.subjectLymphocytic infiltration
dc.subjectPeritumoral
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectMedicine, general & internal
dc.subjectGeneral & internal medicine
dc.titlePeritumoral and intratumoral lymphocytic infiltration and stromal reaction in high-risk endometrioid carcinomas
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication736328be-f008-46e1-825a-46199f11dad9
relation.isAuthorOfPublication1ce7be89-9690-438f-b756-18b50aad8607
relation.isAuthorOfPublication2f0a7090-a0f8-4520-aa3f-0171466752bd
relation.isAuthorOfPublication5e129638-8221-4fc2-8956-7c31d3fea07b
relation.isAuthorOfPublication.latestForDiscovery736328be-f008-46e1-825a-46199f11dad9

Files

Collections