Publication: Choline or cdp-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally-induced endotoxic shock
dc.contributor.author | Ozarda, Yesim | |
dc.contributor.author | Ceron, Jose Joaquin | |
dc.contributor.author | Buturak, Ali | |
dc.contributor.author | Ulus, Ismail H. | |
dc.contributor.buuauthor | Kocaturk, Meric | |
dc.contributor.buuauthor | KOCATÜRK, MERİÇ | |
dc.contributor.buuauthor | Yilmaz, Zeki | |
dc.contributor.buuauthor | YILMAZ, ZEKİ | |
dc.contributor.buuauthor | Cansev, Mehmet | |
dc.contributor.buuauthor | CANSEV, MEHMET | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Veteriner Fakültesi. | |
dc.contributor.orcid | 0000-0002-2849-1222 | |
dc.contributor.orcid | 0000-0001-9836-0749 | |
dc.contributor.orcid | 0000-0003-2918-5064 | |
dc.contributor.orcid | 0000-0002-8654-1793 | |
dc.contributor.researcherid | H-9043-2015 | |
dc.contributor.researcherid | D-5340-2015 | |
dc.contributor.researcherid | V-5578-2017 | |
dc.contributor.researcherid | A-9637-2008 | |
dc.date.accessioned | 2024-06-26T12:45:01Z | |
dc.date.available | 2024-06-26T12:45:01Z | |
dc.date.issued | 2021-10-27 | |
dc.description.abstract | Endotoxin shock is associated with severe impairments in cardiovascular and respiratory functions. We showed previously that choline or cytidine-5 '-diphosphocholine (CDP-choline) provides beneficial effects in experimental endotoxin shock in dogs. The objective of the present study was to determine the effects of choline or CDPcholine on endotoxin-induced cardiovascular and respiratory dysfunctions. Dogs were treated intravenously (i.v.) with saline or endotoxin (LPS, 0.1 mg/kg) 5 min before i.v. infusion of saline, choline (20 mg/kg) or CDP-choline (70 mg/kg). Blood pressure, cardiac rate, myocardial and left ventricular functions, respiratory rate, blood gases, serum electrolytes and cardiac injury markers were determined before and at 0.5-48 h after endotoxin. Plasma tumor necrosis factor alpha (TNF-alpha), high mobility group box-1 (HMGB1), catecholamine and nitric oxide (NO) levels were measured 2 h and 24 h after the treatments. Endotoxin caused immediate and sustained reductions in blood pressure, cardiac output, pO2 and pH; changes in left ventricular functions, structure and volume parameters; and elevations in heart rate, respiratory rate, pCO2 and serum electrolytes (Na, K, Cl, Ca and P). Endotoxin also resulted in elevations in blood levels of cardiac injury markers, TNF-alpha, HMGB1, catecholamine and NO. In choline- or CDP-choline-treated dogs, all endotoxin effects were much smaller in magnitude and shorter in duration than observed values in controls. These data show that treatment with choline or CDP-choline improves functions of cardiovascular and respiratory systems in experimental endotoxemia and suggest that they may be useful in treatment of endotoxin shock in clinical setting. | |
dc.identifier.doi | 10.1016/j.rvsc.2021.10.010 | |
dc.identifier.endpage | 128 | |
dc.identifier.issn | 0034-5288 | |
dc.identifier.startpage | 116 | |
dc.identifier.uri | https://doi.org/10.1016/j.rvsc.2021.10.010 | |
dc.identifier.uri | https://hdl.handle.net/11452/42456 | |
dc.identifier.volume | 141 | |
dc.identifier.wos | 000714142900010 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.relation.journal | Research In Veterinary Science | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Adrenal tyrosine-hydroxylase | |
dc.subject | Reverses hypotension | |
dc.subject | Acetylcholine synthesis | |
dc.subject | Blood-pressure | |
dc.subject | Canine model | |
dc.subject | Involvement | |
dc.subject | Release | |
dc.subject | Rat | |
dc.subject | Induction | |
dc.subject | Stimulation | |
dc.subject | Choline | |
dc.subject | Endotoxemia | |
dc.subject | Sepsis | |
dc.subject | Cardiopulmonary function | |
dc.subject | Dogs | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Veterinary sciences | |
dc.subject | Veterinary sciences | |
dc.title | Choline or cdp-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally-induced endotoxic shock | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | e5873878-33c6-4ae4-89e6-5c1c62fd4768 | |
relation.isAuthorOfPublication | f5c45ca8-95ff-4f54-8b7d-67fa0acfe53f | |
relation.isAuthorOfPublication | 162b5961-162a-4862-89cd-97b30e2a2552 | |
relation.isAuthorOfPublication.latestForDiscovery | e5873878-33c6-4ae4-89e6-5c1c62fd4768 |