Publication:
Choline or cdp-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally-induced endotoxic shock

dc.contributor.authorOzarda, Yesim
dc.contributor.authorCeron, Jose Joaquin
dc.contributor.authorButurak, Ali
dc.contributor.authorUlus, Ismail H.
dc.contributor.buuauthorKocaturk, Meric
dc.contributor.buuauthorKOCATÜRK, MERİÇ
dc.contributor.buuauthorYilmaz, Zeki
dc.contributor.buuauthorYILMAZ, ZEKİ
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.buuauthorCANSEV, MEHMET
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi.
dc.contributor.orcid0000-0002-2849-1222
dc.contributor.orcid0000-0001-9836-0749
dc.contributor.orcid0000-0003-2918-5064
dc.contributor.orcid0000-0002-8654-1793
dc.contributor.researcheridH-9043-2015
dc.contributor.researcheridD-5340-2015
dc.contributor.researcheridV-5578-2017
dc.contributor.researcheridA-9637-2008
dc.date.accessioned2024-06-26T12:45:01Z
dc.date.available2024-06-26T12:45:01Z
dc.date.issued2021-10-27
dc.description.abstractEndotoxin shock is associated with severe impairments in cardiovascular and respiratory functions. We showed previously that choline or cytidine-5 '-diphosphocholine (CDP-choline) provides beneficial effects in experimental endotoxin shock in dogs. The objective of the present study was to determine the effects of choline or CDPcholine on endotoxin-induced cardiovascular and respiratory dysfunctions. Dogs were treated intravenously (i.v.) with saline or endotoxin (LPS, 0.1 mg/kg) 5 min before i.v. infusion of saline, choline (20 mg/kg) or CDP-choline (70 mg/kg). Blood pressure, cardiac rate, myocardial and left ventricular functions, respiratory rate, blood gases, serum electrolytes and cardiac injury markers were determined before and at 0.5-48 h after endotoxin. Plasma tumor necrosis factor alpha (TNF-alpha), high mobility group box-1 (HMGB1), catecholamine and nitric oxide (NO) levels were measured 2 h and 24 h after the treatments. Endotoxin caused immediate and sustained reductions in blood pressure, cardiac output, pO2 and pH; changes in left ventricular functions, structure and volume parameters; and elevations in heart rate, respiratory rate, pCO2 and serum electrolytes (Na, K, Cl, Ca and P). Endotoxin also resulted in elevations in blood levels of cardiac injury markers, TNF-alpha, HMGB1, catecholamine and NO. In choline- or CDP-choline-treated dogs, all endotoxin effects were much smaller in magnitude and shorter in duration than observed values in controls. These data show that treatment with choline or CDP-choline improves functions of cardiovascular and respiratory systems in experimental endotoxemia and suggest that they may be useful in treatment of endotoxin shock in clinical setting.
dc.identifier.doi10.1016/j.rvsc.2021.10.010
dc.identifier.endpage128
dc.identifier.issn0034-5288
dc.identifier.startpage116
dc.identifier.urihttps://doi.org/10.1016/j.rvsc.2021.10.010
dc.identifier.urihttps://hdl.handle.net/11452/42456
dc.identifier.volume141
dc.identifier.wos000714142900010
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherElsevier
dc.relation.journalResearch In Veterinary Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdrenal tyrosine-hydroxylase
dc.subjectReverses hypotension
dc.subjectAcetylcholine synthesis
dc.subjectBlood-pressure
dc.subjectCanine model
dc.subjectInvolvement
dc.subjectRelease
dc.subjectRat
dc.subjectInduction
dc.subjectStimulation
dc.subjectCholine
dc.subjectEndotoxemia
dc.subjectSepsis
dc.subjectCardiopulmonary function
dc.subjectDogs
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectVeterinary sciences
dc.subjectVeterinary sciences
dc.titleCholine or cdp-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally-induced endotoxic shock
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicatione5873878-33c6-4ae4-89e6-5c1c62fd4768
relation.isAuthorOfPublicationf5c45ca8-95ff-4f54-8b7d-67fa0acfe53f
relation.isAuthorOfPublication162b5961-162a-4862-89cd-97b30e2a2552
relation.isAuthorOfPublication.latestForDiscoverye5873878-33c6-4ae4-89e6-5c1c62fd4768

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