Publication:
Serum indoleamine 2,3-dioxygenase level and diagnostic value in patients with rosacea

dc.contributor.authorOdabaşı, Merve Sena
dc.contributor.buuauthorYAZİCİ, SERKAN
dc.contributor.buuauthorÖzkaya, Güven
dc.contributor.buuauthorÖZKAYA, GÜVEN
dc.contributor.buuauthorBaşkan, Emel Bülbül
dc.contributor.buuauthorYILMAZTEPE ORAL, ARZU
dc.contributor.buuauthorBÜLBÜL BAŞKAN, EMEL
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
dc.contributor.orcid0000-0001-6407-0962
dc.contributor.orcid0000-0003-0297-846X
dc.contributor.researcheridJAX-2733-2023
dc.contributor.researcheridA-4421-2016
dc.date.accessioned2024-11-07T06:02:16Z
dc.date.available2024-11-07T06:02:16Z
dc.date.issued2023-01-01
dc.description.abstractBackground: Indoleamine 2,3-dioxygenase (IDO), an enzyme in the first step of tryptophan catabolism, plays a role in the pathogenesis of various malignancies and inflammatory diseases. Although its pathogenesis is unclear, vascular dysregulation and chronic inflammation are the most common culprits for rosacea. Objectives: The aim of this study is to evaluate the relationship between IDO and rosacea and whether there is a correlation with disease severity. Methods: Fifty-two patients with rosacea and 29 healthy volunteers were recruited. The patients were grouped according to severity stage, period, and subtype of the disease. Serum IDO levels were measured with enzyme-linked immunosorbent assay. Results: Serum IDO levels were significantly higher in the patients with rosacea compared to the healthy controls (P < 0.001) and were significantly higher in the patients in remission period and with papulopustular type rosacea compared to the controls (P = 0.002 and P = 0.001, respectively). The serum IDO levels of the female rosacea patients were higher than those of the healthy female controls (P < 0.001). When the diagnostic value of the parameter was investigated, it was observed that the serum IDO level has high sensitivity (83.3%) and specificity (76.1%), with a cutoff value of 47.1 ng/mL for female rosacea patients. Conclusion: IDO was found to increase in rosacea patients. With the high specificity and sensitivity observed, especially in female patients, IDO may be a supporting parameter in the diagnosis of rosacea.
dc.identifier.doi10.4103/ds.DS-D-22-00055
dc.identifier.endpage30
dc.identifier.issn1027-8117
dc.identifier.issue1
dc.identifier.startpage25
dc.identifier.urihttps://doi.org/10.4103/ds.DS-D-22-00055
dc.identifier.urihttps://hdl.handle.net/11452/47529
dc.identifier.volume41
dc.identifier.wos000974491300005
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.journalDermatologica Sinica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIdo activity
dc.subjectExpression
dc.subjectInduction
dc.subjectDisease
dc.subjectIndoleamine 2,3-dioxygenase
dc.subjectInflammatory skin disease
dc.subjectRosacea
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectDermatology
dc.titleSerum indoleamine 2,3-dioxygenase level and diagnostic value in patients with rosacea
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery9bc5c730-985b-47f5-a6ce-72d472c96078

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