Publication:
Modified histopathological classification with age-related glomerulosclerosis for predicting kidney survival in ANCA-associated glomerulonephritis

dc.contributor.authorAydın, Mehmet Fethullah
dc.contributor.authorYıldız, Abdülmecit
dc.contributor.authorOruç, Ayşegül
dc.contributor.authorVuruşkan, Berna Aytaç
dc.contributor.authorAkgür, Suat
dc.contributor.authorAyar, Yavuz
dc.contributor.authorGüllülü, Mustafa
dc.contributor.authorDilek, Kamil
dc.contributor.authorYavuz, Mahmut
dc.contributor.authorOrtaç, Hatice
dc.contributor.authorErsoy, Alparslan
dc.contributor.buuauthorAydın, Mehmet Fethullah
dc.contributor.buuauthorYILDIZ, ABDULMECİT
dc.contributor.buuauthorORUÇ, AYŞEGÜL
dc.contributor.buuauthorAYTAÇ VURUŞKAN, BERNA
dc.contributor.buuauthorOrtaç, Hatice
dc.contributor.buuauthorGÜLLÜLÜ, MUSTAFA
dc.contributor.buuauthorDİLEK, KAMİL
dc.contributor.buuauthorERSOY, ALPARSLAN
dc.contributor.buuauthorYAVUZ, MAHMUT
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-0342-9692
dc.contributor.orcid0000-0002-5665-7402
dc.contributor.researcheridAAJ-8220-2020
dc.contributor.researcheridHIG-9032-2022
dc.contributor.researcheridAAH-4002-2021
dc.contributor.researcheridEEJ-1452-2022
dc.contributor.researcheridJGS-9425-2023
dc.contributor.researcheridEUF-5229-2022
dc.contributor.researcheridEHM-7377-2022
dc.contributor.researcheridHJF-9598-2022
dc.contributor.researcheridCPX-5894-2022
dc.date.accessioned2024-11-08T06:26:14Z
dc.date.available2024-11-08T06:26:14Z
dc.date.issued2022-09-25
dc.description.abstractBackground The histopathological classification of ANCA-GN divides patients into four groups based on signs of glomerular injury. However, this classification did not consider age-related glomerulosclerosis. In this study, we aimed to compare the prediction of renal survival between Berden's ANCA-GN histopathological classification and ANCA-GN histopathological classification modified with age-related glomerulosclerosis. Methods Between January 2004 and December 2019, 65 patients diagnosed with ANCA-GN were enrolled. Demographic, laboratory, and histopathologic findings were retrospectively analyzed. Renal survival analyses were compared according to classical and modified ANCA-GN histopathological classifications. Multivariate Cox regression analysis for the factors affecting renal survival was performed. Results In Berden's ANCA-GN histopathological classification, 15 patients were in the focal group, 21 in the crescentic, 21 in the sclerotic, and 8 in the mixed group. The ANCA-GN histopathological classification model generated statistically significant predictions for renal survival (p = 0.022). When the histopathological classification was modified with age-related glomerulosclerosis, eight of the nine patients previously classified in the sclerotic group were classified in the mixed and one in the crescentic groups. Modification of histopathological classification with age-related glomerulosclerosis increases the statistical significance in renal survival analysis (p = 0.009). The multivariate Cox regression analysis showed that the disease-related global sclerotic glomeruli percentage and serum creatinine level were significant independent factors. Conclusion Modification of Berden's ANCA-GN histopathological classification model with age-related glomerulosclerosis may increase the statistical significance of the histopathological classification model.
dc.identifier.doi10.1007/s11255-022-03371-6
dc.identifier.endpage748
dc.identifier.issn0301-1623
dc.identifier.issue3
dc.identifier.startpage741
dc.identifier.urihttps://doi.org/10.1007/s11255-022-03371-6
dc.identifier.urihttps://link.springer.com/article/10.1007/s11255-022-03371-6
dc.identifier.urihttps://hdl.handle.net/11452/47611
dc.identifier.volume55
dc.identifier.wos000858800000002
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer
dc.relation.journalInternational Urology and Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntibody-associated glomerulonephritis
dc.subjectHistological classification
dc.subjectNephrosclerosis
dc.subjectValidation
dc.subjectDisease
dc.subjectBiopsy
dc.subjectAnca
dc.subjectAnca-associated vasculitis
dc.subjectAnti-neutrophil cytoplasmic antibodies
dc.subjectAge-related glomerulosclerosis
dc.subjectHistopathological classification
dc.subjectRenal pathology
dc.subjectUrology & nephrology
dc.titleModified histopathological classification with age-related glomerulosclerosis for predicting kidney survival in ANCA-associated glomerulonephritis
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Nefroloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Biyoistatistik Ana Bilim Dalı
relation.isAuthorOfPublicatione0f20ddb-a439-4c4a-b87e-d468370abf60
relation.isAuthorOfPublicationbd386ce4-0765-45b7-9a09-c10b5eca584a
relation.isAuthorOfPublicationb2f0fe6f-b16a-49fd-8a29-8bb3d5cb4671
relation.isAuthorOfPublication47f5ec68-c479-4f62-9aed-37ba604a689c
relation.isAuthorOfPublication3483aae5-153f-4555-aa02-81efd2ace822
relation.isAuthorOfPublication3b0ea0d7-f953-4c53-9e92-e260b04f90b4
relation.isAuthorOfPublicationa096c377-129d-4ccb-94eb-205aaea33a01
relation.isAuthorOfPublication.latestForDiscoverye0f20ddb-a439-4c4a-b87e-d468370abf60

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Aydin_vd_2023.pdf
Size:
544.57 KB
Format:
Adobe Portable Document Format

Collections