Publication:
Comparing the effect of ammonium molybdate versus ammonium molybdate and menbutone on hepatic functions of sheep with subclinical copper poisoning

dc.contributor.authorKaçar, Yiğit
dc.contributor.authorMecitoğlu, Zafer
dc.contributor.authorBatmaz, Hasan
dc.contributor.buuauthorKAÇAR, YİĞİT
dc.contributor.buuauthorMECİTOĞLU, ZAFER
dc.contributor.buuauthorBATMAZ, HASAN
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı
dc.contributor.researcheridAAH-4972-2021
dc.contributor.researcheridFQB-3477-2022
dc.contributor.researcheridHXD-1722-2023
dc.date.accessioned2024-09-12T06:00:39Z
dc.date.available2024-09-12T06:00:39Z
dc.date.issued2022-09-27
dc.description.abstractThis study aimed to investigate the effect of using menbutone in addition to ammonium molybdate on liver enzymes in sheep naturally poisoned with copper. Merino lambs (n = 30), naturally poisoned with copper and which also had high liver enzyme levels, were divided into two groups, each with 15 lambs. The AM + MEN group received ammonium molybdate and menbutone and the AM group received only ammonium molybdate solution. Both groups received 1.7% ammonium molybdate solution (1 mL per 10 kg body weight [BW]) subcutaneously on 0, 2nd and 4th days of the study. Menbutone (Genabil (R), Boehringer Ingelheim, Germany) was administered intramuscularly at a dose of 10 mg/kg BW on days 0 and 2, in addition to ammonium molybdate in the AM + MEN group. Blood samples were collected on days 0 and 7, and aspartate aminotransferase (AST), gamma-glutamyltranspeptidase (GGT) and creatinine levels were evaluated. Over 7 days, AST levels decreased from 351.04 +/- 63.50 IU/L to 286.40 +/- 55.68 IU/L in the AM group (P > 0.05) and from 425.00 +/- 119.25 IU/L to 240.83 +/- 29.62 IU/L in the AM + MEN group (P <= 0.05). GGT levels decreased from 121.16 +/- 15.88 IU/L to 110.39 +/- 10.13 IU/L in the AM group (P > 0.05) and 124.52 +/- 15.50 to 98.60 +/- 9.08 IU/L in the AM + MEN group (P <= 0.05). Based on these findings, the use of menbutone, in addition to ammonium molybdate, has significantly reduced the level of liver enzymes.
dc.identifier.doi10.1111/avj.13207
dc.identifier.eissn1751-0813
dc.identifier.endpage599
dc.identifier.issn0005-0423
dc.identifier.issue12
dc.identifier.startpage596
dc.identifier.urihttps://doi.org/10.1111/avj.13207
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/avj.13207
dc.identifier.urihttps://hdl.handle.net/11452/44609
dc.identifier.volume100
dc.identifier.wos000859903700001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWiley
dc.relation.journalAustralian Veterinary Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiagnosis
dc.subjectAst
dc.subjectCopper poisoning
dc.subjectGgt
dc.subjectMenbutone
dc.subjectSheep
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectVeterinary sciences
dc.titleComparing the effect of ammonium molybdate versus ammonium molybdate and menbutone on hepatic functions of sheep with subclinical copper poisoning
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication73c59977-f1a6-4737-9b24-60658c2706c4
relation.isAuthorOfPublication66f17370-913f-4987-b8fb-1e44969deff2
relation.isAuthorOfPublication485139b1-b60e-4e07-a83a-eb553b0a835d
relation.isAuthorOfPublication.latestForDiscovery73c59977-f1a6-4737-9b24-60658c2706c4

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