Publication: Comparing the effect of ammonium molybdate versus ammonium molybdate and menbutone on hepatic functions of sheep with subclinical copper poisoning
dc.contributor.author | Kaçar, Yiğit | |
dc.contributor.author | Mecitoğlu, Zafer | |
dc.contributor.author | Batmaz, Hasan | |
dc.contributor.buuauthor | KAÇAR, YİĞİT | |
dc.contributor.buuauthor | MECİTOĞLU, ZAFER | |
dc.contributor.buuauthor | BATMAZ, HASAN | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı | |
dc.contributor.researcherid | AAH-4972-2021 | |
dc.contributor.researcherid | FQB-3477-2022 | |
dc.contributor.researcherid | HXD-1722-2023 | |
dc.date.accessioned | 2024-09-12T06:00:39Z | |
dc.date.available | 2024-09-12T06:00:39Z | |
dc.date.issued | 2022-09-27 | |
dc.description.abstract | This study aimed to investigate the effect of using menbutone in addition to ammonium molybdate on liver enzymes in sheep naturally poisoned with copper. Merino lambs (n = 30), naturally poisoned with copper and which also had high liver enzyme levels, were divided into two groups, each with 15 lambs. The AM + MEN group received ammonium molybdate and menbutone and the AM group received only ammonium molybdate solution. Both groups received 1.7% ammonium molybdate solution (1 mL per 10 kg body weight [BW]) subcutaneously on 0, 2nd and 4th days of the study. Menbutone (Genabil (R), Boehringer Ingelheim, Germany) was administered intramuscularly at a dose of 10 mg/kg BW on days 0 and 2, in addition to ammonium molybdate in the AM + MEN group. Blood samples were collected on days 0 and 7, and aspartate aminotransferase (AST), gamma-glutamyltranspeptidase (GGT) and creatinine levels were evaluated. Over 7 days, AST levels decreased from 351.04 +/- 63.50 IU/L to 286.40 +/- 55.68 IU/L in the AM group (P > 0.05) and from 425.00 +/- 119.25 IU/L to 240.83 +/- 29.62 IU/L in the AM + MEN group (P <= 0.05). GGT levels decreased from 121.16 +/- 15.88 IU/L to 110.39 +/- 10.13 IU/L in the AM group (P > 0.05) and 124.52 +/- 15.50 to 98.60 +/- 9.08 IU/L in the AM + MEN group (P <= 0.05). Based on these findings, the use of menbutone, in addition to ammonium molybdate, has significantly reduced the level of liver enzymes. | |
dc.identifier.doi | 10.1111/avj.13207 | |
dc.identifier.eissn | 1751-0813 | |
dc.identifier.endpage | 599 | |
dc.identifier.issn | 0005-0423 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 596 | |
dc.identifier.uri | https://doi.org/10.1111/avj.13207 | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1111/avj.13207 | |
dc.identifier.uri | https://hdl.handle.net/11452/44609 | |
dc.identifier.volume | 100 | |
dc.identifier.wos | 000859903700001 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.relation.journal | Australian Veterinary Journal | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Diagnosis | |
dc.subject | Ast | |
dc.subject | Copper poisoning | |
dc.subject | Ggt | |
dc.subject | Menbutone | |
dc.subject | Sheep | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Veterinary sciences | |
dc.title | Comparing the effect of ammonium molybdate versus ammonium molybdate and menbutone on hepatic functions of sheep with subclinical copper poisoning | |
dc.type | Article | |
dspace.entity.type | Publication | |
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relation.isAuthorOfPublication.latestForDiscovery | 73c59977-f1a6-4737-9b24-60658c2706c4 |