Publication:
Evaluation of polylactide film for prevention of pericardial adhesion in a rabbit model

dc.contributor.authorGürbüz, Orçun
dc.contributor.authorErcan, Abdulkadir
dc.contributor.authorBiçer, Murat
dc.contributor.authorKumtepe, Gencehan
dc.contributor.authorBayram, Sami
dc.contributor.authorŞenkaya, Işık
dc.contributor.authorSaba, Davit
dc.contributor.buuauthorBİÇER, MURAT
dc.contributor.buuauthorBAYRAM, AHMET SAMİ
dc.contributor.buuauthorŞENKAYA SIĞNAK, IŞIK
dc.contributor.buuauthorSaba, Davit
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.
dc.contributor.researcheridABC-2231-2020
dc.contributor.researcheridABB-7580-2020
dc.contributor.researcheridDTC-2331-2022
dc.contributor.researcheridDPS-9311-2022
dc.date.accessioned2024-08-05T09:17:23Z
dc.date.available2024-08-05T09:17:23Z
dc.date.issued2015-01-01
dc.description.abstractBackground: This study aims to evaluate the efficacy of a bioabsorbable polylactide film, which was proven to be effective in preventing pelvic adhesions, in prevention of postoperative pericardial adhesions in an animal model.Methods: Forty New Zealand white rabbits were divided equally into control and treatment groups. Subjects were performed left anterior thoracotomy and partial pericardiectomy followed by epicardial abrasion. In control groups (group 1 and 2), the pericardium was left open to allow retrosternal adhesions. In treatment groups (group 3 and 4), the pericardial defect was closed with 0.02 mm bioabsorbable polylactide film. Postoperative macroscopic and microscopic evaluations were made by the same blinded observers at the end of the third week in group 1 and 3, and at the end of the sixth week in group 2 and 4.Results: Macroscopic and histopathologic examinations revealed no significant differences between control and treatment groups in terms of adhesion formation. However, polylactide film supported the growth of a mesothelium-like layer in the treatment groups.Conclusion: Although polylactide film assists in the regeneration of mesothelial cells layer, it does not prevent the development of pericardial adhesions.
dc.identifier.doi10.5606/tgkdc.dergisi.2015.10487
dc.identifier.endpage104
dc.identifier.issn1301-5680
dc.identifier.issue1
dc.identifier.startpage98
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2015.10487
dc.identifier.urihttps://tgkdc.dergisi.org/text.php3?id=2157
dc.identifier.urihttps://hdl.handle.net/11452/43703
dc.identifier.volume23
dc.identifier.wos000348962500016
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherBaycinar Medical Publ-Bayçınar Tıbbi Yayıncılık
dc.relation.journalTürk Göğüs Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHyaluronic-acid
dc.subjectReduction
dc.subjectMembrane
dc.subjectReoperation
dc.subjectSubstitutes
dc.subjectSurgery
dc.subjectBioabsorbable polylactide film
dc.subjectCardiac surgery
dc.subjectPericardial adhesions
dc.subjectSurgery
dc.titleEvaluation of polylactide film for prevention of pericardial adhesion in a rabbit model
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication10e6b267-dba0-4030-a6f8-a296856cf7ba
relation.isAuthorOfPublicationbdb7801d-f0bc-4abc-af2c-5bf7df23fbd5
relation.isAuthorOfPublication2a293106-b1cc-4862-991b-7c0cc74d3ea2
relation.isAuthorOfPublication.latestForDiscovery10e6b267-dba0-4030-a6f8-a296856cf7ba

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