Publication:
Cytotoxic potential of rare plant salvia candidissima subsp candidissima on breast cancer cells

dc.contributor.authorÖzel, Mustafa Zafer
dc.contributor.authorFırat, Mehmet
dc.contributor.buuauthorErtürk, Elif
dc.contributor.buuauthorERTÜRK, ELİF
dc.contributor.buuauthorOnur, Ömer Enes
dc.contributor.buuauthorAydın, İpek
dc.contributor.buuauthorİPEK, AYDIN
dc.contributor.buuauthorArı, Ferda
dc.contributor.buuauthorARI, FERDA
dc.contributor.departmentBursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Biyoloji Bölümü.
dc.contributor.orcid0000-0001-8707-5918
dc.contributor.orcid0000-0002-6729-7908
dc.contributor.researcheridIUO-8513-2023
dc.contributor.researcheridAAG-7012-2021
dc.contributor.researcheridJQI-3400-2023
dc.date.accessioned2024-10-22T05:40:35Z
dc.date.available2024-10-22T05:40:35Z
dc.date.issued2023-01-01
dc.description.abstractBreast cancer is the leading cause of cancer-related deaths in women throughout the world. Research on natural anti-cancer products from plants has gained traction. Salvia L. species and their derivatives are rare in Turkey and have suggested for their potential anti-cancer effects. The aim of this study is to assess the potential cytotoxic/apoptotic activities of methanol extract of Salvia candidissima Vahl. subsp. candidissima (SCE) on MCF-7 and MDA-MB-231 breast cancer cells. A GCxGC-TOF/MS system and a dual stage commercial thermal desorption injector were used to determine the chemical components of SCE. MTT and ATP viability tests were used to investigate the anti-growth activity. The apoptosis-inducing effect was assessed using a fluorescence staining method. Caspase-cleaved keratin 18 (ccK18, M30-antigen) levels measured by M30-CytoDeath ELISA Kit. The results showed that SCE suppressed the survival of the MCF-7 and MDA-MB-231 breast cancer cells in a dose-dependent manner, based on the findings of both MTT and ATP cell viability tests and pyknotic cell nuclei were observed via fluorescent staining in both cell lines after 48 h of treatment. The treatment group had greater levels of caspase-cleaved keratin 18 in the MCF-7 cells than the untreated group. These results showed that SCE triggers apoptosis, causes cell death in MCF-7 and MDA-MB-231 cell lines. SCE may become promising therapeutic strategy in the treatment of breast cancer with further in vitro and in vivo studies.
dc.identifier.doi10.1590/1678-4324-2023220358
dc.identifier.issn1516-8913
dc.identifier.urihttps://doi.org/10.1590/1678-4324-2023220358
dc.identifier.urihttps://hdl.handle.net/11452/46811
dc.identifier.volume66
dc.identifier.wos001019697900001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherInst Tecnologia Parana
dc.relation.bapBAP
dc.relation.journalBrazilian Archives Of Biology And Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBeta-caryophyllene
dc.subjectEssential oil
dc.subjectChemical-composition
dc.subjectGrowth-inhibition
dc.subjectMyrica-rubra
dc.subjectApoptosis
dc.subjectRoots
dc.subjectAntioxidant
dc.subjectInduction
dc.subjectSclareol
dc.subjectSalvia candidissima vahl
dc.subjectSubsp
dc.subjectCandidissima
dc.subjectBreast cancer
dc.subjectMcf-7
dc.subjectMda-mb-231
dc.subjectCytotoxicity
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine - other topics
dc.subjectBiology
dc.titleCytotoxic potential of rare plant salvia candidissima subsp candidissima on breast cancer cells
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication54fbb8ee-6806-4d77-9430-9b360d81a2ab
relation.isAuthorOfPublication5a1dd361-f549-401f-9131-862a6347b97f
relation.isAuthorOfPublication1dd517bb-3e11-411e-a8db-27d448dcd55e
relation.isAuthorOfPublication.latestForDiscovery54fbb8ee-6806-4d77-9430-9b360d81a2ab

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