Publication: Cytotoxic potential of rare plant salvia candidissima subsp candidissima on breast cancer cells
dc.contributor.author | Özel, Mustafa Zafer | |
dc.contributor.author | Fırat, Mehmet | |
dc.contributor.buuauthor | Ertürk, Elif | |
dc.contributor.buuauthor | ERTÜRK, ELİF | |
dc.contributor.buuauthor | Onur, Ömer Enes | |
dc.contributor.buuauthor | Aydın, İpek | |
dc.contributor.buuauthor | İPEK, AYDIN | |
dc.contributor.buuauthor | Arı, Ferda | |
dc.contributor.buuauthor | ARI, FERDA | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Biyoloji Bölümü. | |
dc.contributor.orcid | 0000-0001-8707-5918 | |
dc.contributor.orcid | 0000-0002-6729-7908 | |
dc.contributor.researcherid | IUO-8513-2023 | |
dc.contributor.researcherid | AAG-7012-2021 | |
dc.contributor.researcherid | JQI-3400-2023 | |
dc.date.accessioned | 2024-10-22T05:40:35Z | |
dc.date.available | 2024-10-22T05:40:35Z | |
dc.date.issued | 2023-01-01 | |
dc.description.abstract | Breast cancer is the leading cause of cancer-related deaths in women throughout the world. Research on natural anti-cancer products from plants has gained traction. Salvia L. species and their derivatives are rare in Turkey and have suggested for their potential anti-cancer effects. The aim of this study is to assess the potential cytotoxic/apoptotic activities of methanol extract of Salvia candidissima Vahl. subsp. candidissima (SCE) on MCF-7 and MDA-MB-231 breast cancer cells. A GCxGC-TOF/MS system and a dual stage commercial thermal desorption injector were used to determine the chemical components of SCE. MTT and ATP viability tests were used to investigate the anti-growth activity. The apoptosis-inducing effect was assessed using a fluorescence staining method. Caspase-cleaved keratin 18 (ccK18, M30-antigen) levels measured by M30-CytoDeath ELISA Kit. The results showed that SCE suppressed the survival of the MCF-7 and MDA-MB-231 breast cancer cells in a dose-dependent manner, based on the findings of both MTT and ATP cell viability tests and pyknotic cell nuclei were observed via fluorescent staining in both cell lines after 48 h of treatment. The treatment group had greater levels of caspase-cleaved keratin 18 in the MCF-7 cells than the untreated group. These results showed that SCE triggers apoptosis, causes cell death in MCF-7 and MDA-MB-231 cell lines. SCE may become promising therapeutic strategy in the treatment of breast cancer with further in vitro and in vivo studies. | |
dc.identifier.doi | 10.1590/1678-4324-2023220358 | |
dc.identifier.issn | 1516-8913 | |
dc.identifier.uri | https://doi.org/10.1590/1678-4324-2023220358 | |
dc.identifier.uri | https://hdl.handle.net/11452/46811 | |
dc.identifier.volume | 66 | |
dc.identifier.wos | 001019697900001 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Inst Tecnologia Parana | |
dc.relation.bap | BAP | |
dc.relation.journal | Brazilian Archives Of Biology And Technology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Beta-caryophyllene | |
dc.subject | Essential oil | |
dc.subject | Chemical-composition | |
dc.subject | Growth-inhibition | |
dc.subject | Myrica-rubra | |
dc.subject | Apoptosis | |
dc.subject | Roots | |
dc.subject | Antioxidant | |
dc.subject | Induction | |
dc.subject | Sclareol | |
dc.subject | Salvia candidissima vahl | |
dc.subject | Subsp | |
dc.subject | Candidissima | |
dc.subject | Breast cancer | |
dc.subject | Mcf-7 | |
dc.subject | Mda-mb-231 | |
dc.subject | Cytotoxicity | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine - other topics | |
dc.subject | Biology | |
dc.title | Cytotoxic potential of rare plant salvia candidissima subsp candidissima on breast cancer cells | |
dc.type | Article | |
dspace.entity.type | Publication | |
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relation.isAuthorOfPublication.latestForDiscovery | 54fbb8ee-6806-4d77-9430-9b360d81a2ab |