Publication: Mitochondrial mirnas (mitomirs): Their potential roles in breast and other cancers
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Date
2022-09-01
Authors
Ertürk, Elif
ARI, FERDA
Onur, Ömer Enes
Akgün, Oğuzhan
Arı, Ferda
Tuna, Gonca
Yıldız, Yaren
Authors
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Publisher
Elsevier Sci Ltd
Abstract
Breast cancer is the most common cancer in women worldwide. MicroRNAs (miRNAs) are non-coding RNAs that are involved in the post-transcriptional regulation of gene expression. Although miRNAs mainly act in the cytoplasm, they can be found in the mitochondrial compartment of the cell. These miRNAs called "MitomiR", they can change mitochondrial functions by regulating proteins at the mitochondrial level and cause cancer.In this review, we have aimed to explain miRNA biogenesis, transport pathways to mitochondria, and summarize mitomiRs that have been shown to play an important role in mitochondrial function, especially in the initiation and progression of breast cancer.
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Keywords
Transcription factor, Rna import, Microrna, Cell, Expression, Gene, Biogenesis, Apoptosis, Proteins, Hypoxia, Breast cancer, Mirnas, Mitochondria, Mitomirs, Science & technology, Life sciences & biomedicine, Cell biology, Genetics & heredity