Publication:
Modulation of nesfatin-1-induced cardiovascular effects by the central cholinergic system

dc.contributor.buuauthorAydın, Begüm
dc.contributor.buuauthorGüvenç, Gökçen
dc.contributor.buuauthorAltınbaş, Burçin
dc.contributor.buuauthorNiaz, Nasir
dc.contributor.buuauthorYalçın, Murat
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentFizyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-5600-8162
dc.contributor.orcid0000-0002-9534-736X
dc.contributor.orcid0000-0002-1413-3651
dc.contributor.researcheridAAR-6815-2021
dc.contributor.researcheridAAC-4975-2022
dc.contributor.researcheridAAG-6956-2021
dc.contributor.researcheridHLA-3520-2023
dc.contributor.researcheridIYS-2646-2023
dc.contributor.scopusid57194022849
dc.contributor.scopusid56529426800
dc.contributor.scopusid55356919300
dc.contributor.scopusid57060367600
dc.contributor.scopusid57192959734
dc.date.accessioned2024-03-26T08:57:54Z
dc.date.available2024-03-26T08:57:54Z
dc.date.issued2018-05-03
dc.description.abstractNesfatin-1, a peptide whose receptor is yet to be identified, has been shown to be involved in the modulation of feeding, stress, and metabolic responses. Recently, increasing evidence has supported a modulatory role of nesfatin-1 in cardiovascular activity. We have previously reported that nesfatin-1 causes an increase in blood pressure in normotensive and hypotensive rats by increasing plasma catecholamine, vasopressin, and renin levels. Recent reports suggest that nesfatin-1 may activate the central cholinergic system. However, there is no evidence showing an interaction between central nesfatin-1 and the cholinergic system. Therefore, this study aimed to determine whether the central cholinergic system may have a functional role in the nesfatin-1-induced cardiovascular effect observed in normotensive rats. Intracerebroventricular injection of nesfatin-1 caused short-term increases in mean arterial pressure and heart rate responses including bradycardic/tachycardic phases in normotensive animals. Central injection of nesfatin-1 increased the acetylcholine and choline levels in the posterior hypothalamus, as shown in microdialysis studies. Central pretreatment with the cholinergic muscarinic receptor antagonist atropine and/or nicotinic receptor antagonist mecamylamine blocked nesfatin-1-induced cardiovascular effects. In conclusion, the results show that centrally administered nesfatin-1 produces a pressor effect on blood pressure and heart rate responses including bradycardic/tachycardic phases in normotensive rats. Moreover, according to our findings, the central cholinergic system can modulate nesfatin-1-evoked cardiovascular activity.
dc.description.sponsorshipCollege of Pharmacy and Health Sciences, Lipscomb University (CPHS)
dc.identifier.citationAydın, B. vd. (2018). ''Modulation of nesfatin-1-induced cardiovascular effects by the central cholinergic system''. Neuropeptides, 70, 9-15.
dc.identifier.doihttps://doi.org/10.1016/j.npep.2018.05.001
dc.identifier.eissn1532-2785
dc.identifier.endpage15
dc.identifier.issn0143-4179
dc.identifier.pubmed29751997
dc.identifier.scopus2-s2.0-85046634362
dc.identifier.startpage9
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0143417918300386
dc.identifier.urihttps://hdl.handle.net/11452/40626
dc.identifier.volume70
dc.identifier.wos000440957400002
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.collaborationYurt dışı
dc.relation.collaborationYurt içi
dc.relation.journalNeuropeptides
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak215S872
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEndocrinology & metabolism
dc.subjectNeurosciences & neurology
dc.subjectNesfatin-1
dc.subjectBlood pressure
dc.subjectHeart rate
dc.subjectPosterior hypothalamic choline/acetylcholine
dc.subjectCholinergic muscarinic and nicotinic receptors
dc.subjectThromboxane A2 analog
dc.subjectInjected cdp-choline
dc.subjectBlood-pressure
dc.subjectHypotensive rats
dc.subjectConscious rats
dc.subjectSolitary tract
dc.subjectNeurons
dc.subjectBrain
dc.subjectInvolvement
dc.subjectNucleus
dc.subject.emtreeAcetylcholine
dc.subject.emtreeCholine
dc.subject.emtreeMuscarinic receptor
dc.subject.emtreeNesfatin 1
dc.subject.emtreeNeuropeptide
dc.subject.emtreeNicotinic receptor
dc.subject.emtreeUnclassified drug
dc.subject.emtreeAcetylcholine
dc.subject.emtreeCalcium binding protein
dc.subject.emtreeCatecholamine
dc.subject.emtreeCholinergic receptor stimulating agent
dc.subject.emtreeDNA binding protein
dc.subject.emtreeMecamylamine
dc.subject.emtreeNerve protein
dc.subject.emtreeNucleobindin
dc.subject.emtreeVasoconstrictor agent
dc.subject.emtreeVasopressin derivative
dc.subject.emtreeAdult
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeBradycardia
dc.subject.emtreeCardiovascular effect
dc.subject.emtreeCholinergic system
dc.subject.emtreeControlled study
dc.subject.emtreeHeart rate
dc.subject.emtreeMale
dc.subject.emtreeMean arterial pressure
dc.subject.emtreeNonhuman
dc.subject.emtreePosterior hypothalamus
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.emtreeTachycardia
dc.subject.emtreeAnimal
dc.subject.emtreeBlood
dc.subject.emtreeBlood pressure
dc.subject.emtreeBrain
dc.subject.emtreeDrug effect
dc.subject.emtreeHypotension
dc.subject.emtreeMetabolism
dc.subject.emtreeSprague dawley rat
dc.subject.meshAcetylcholine
dc.subject.meshAnimals
dc.subject.meshBlood pressure
dc.subject.meshBrain
dc.subject.meshCalcium-binding proteins
dc.subject.meshCatecholamines
dc.subject.meshCholinergic agents
dc.subject.meshDNA-binding proteins
dc.subject.meshHeart rate
dc.subject.meshHypotension
dc.subject.meshMale
dc.subject.meshMecamylamine
dc.subject.meshNerve tissue proteins
dc.subject.meshRats, sprague-dawley
dc.subject.meshVasoconstrictor agents
dc.subject.meshVasopressins
dc.subject.scopusSubfornical Organ; Animals; Hypothalamic Paraventricular Nucleus
dc.subject.wosEndocrinology & metabolism
dc.subject.wosNeurosciences
dc.titleModulation of nesfatin-1-induced cardiovascular effects by the central cholinergic system
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/Fizyoloji Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

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