Publication:
Hypothalamic volume and asymmetry in the pediatric population: A retrospective mri study

dc.contributor.buuauthorIşıklar, Sefa
dc.contributor.buuauthorIŞIKLAR, SEFA
dc.contributor.buuauthorÖzdemir, Senem Turan
dc.contributor.buuauthorÖzkaya, Güven
dc.contributor.buuauthorÖZKAYA, GÜVEN
dc.contributor.buuauthorÖzpar, Rıfat
dc.contributor.buuauthorÖZPAR, RİFAT
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.
dc.contributor.orcid0000-0002-2070-5193
dc.contributor.orcid0000-0003-0297-846X
dc.contributor.orcid0000-0001-6649-9287
dc.contributor.researcheridAAK-3779-2021
dc.contributor.researcheridA-4421-2016
dc.date.accessioned2024-10-07T05:58:43Z
dc.date.available2024-10-07T05:58:43Z
dc.date.issued2022-08-16
dc.description.abstractThis study investigated age- and sex-related changes in the volumetric development and asymmetry of the normal hypothalamus from birth to 18. Individuals aged 0-18 with MRI from 2012 to 2020 were selected for this retrospective study. Seven hundred individuals (369 [52.7%] Males) who had 3D-T1 sequences and were radiologically normal were included in the study. Hypothalamus volume was calculated using MRICloud automated segmentation pipelines. Hypothalamus asymmetry was calculated as the difference between right and left volumes divided by the mean (in percent). The measurement results of 23 age groups were analyzed with SPSS (ver.23). The mean hypothalamic volume in the first year of life reached 69% of the mean hypothalamic volume between 0 and 18 years (1119.01 +/- 196.09 mm(3)), 88% in the second year. The mean volume of the hypothalamus without mammillary body increased in the five-age segment, while it increased in the six-age segment with mammillary body. Although the hypothalamus volumes of males were larger than females in all age groups, a significant difference was found between the age groups of 3-8 and 12-18 years (p < 0.05). In the pediatric brain, the hypothalamus was right-lateralized between 2.39% and 14.02%. The first 2 years of life were critical in the volumetric development of the hypothalamus. A segmental and logarithmic increase in the hypothalamus volume was demonstrated. In the pediatric brain, asymmetry and sexual dimorphism were detected in the hypothalamus. Information on normal hypothalamus structure and development facilitates the recognition of abnormal developmental trajectories.
dc.identifier.doi10.1007/s00429-022-02542-6
dc.identifier.endpage2501
dc.identifier.issn1863-2653
dc.identifier.issue7
dc.identifier.startpage2489
dc.identifier.urihttps://doi.org/10.1007/s00429-022-02542-6
dc.identifier.urihttps://hdl.handle.net/11452/45928
dc.identifier.volume227
dc.identifier.wos000841087400001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.journalBrain Structure & Function
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBrain-development
dc.subjectSchizophrenia
dc.subjectGender
dc.subjectAtlas
dc.subjectHypothalamus
dc.subjectPediatrics
dc.subjectDevelopment
dc.subjectVolume
dc.subjectAsymmetry
dc.subjectMri
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectAnatomy & morphology
dc.subjectNeurosciences
dc.subjectNeurosciences & neurology
dc.titleHypothalamic volume and asymmetry in the pediatric population: A retrospective mri study
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication8183356b-fb17-47f9-86d8-9566fdeb85ab
relation.isAuthorOfPublication648e85b9-2f4f-4f92-a2d7-794286abd0fd
relation.isAuthorOfPublication597eca82-1312-4286-b1b1-b47aec03619c
relation.isAuthorOfPublication.latestForDiscovery8183356b-fb17-47f9-86d8-9566fdeb85ab

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