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The evaluation to relationship between serum vascular endothelial growth factor (VEGF) level, metastases and other tumor markers in patients with lung cancer

dc.contributor.authorSağlam, Dursun Ali
dc.contributor.authorUrsavaş, Ahmet
dc.contributor.authorKaradağ, Mehmet
dc.contributor.authorOral, Arzu Yılmaztepe
dc.contributor.authorCoşkun, Funda
dc.contributor.authorGözü, R. Oktay
dc.contributor.buuauthorSağlam, Dursun Ali
dc.contributor.buuauthorKARADAĞ, MEHMET
dc.contributor.buuauthorURSAVAŞ, AHMET
dc.contributor.buuauthorYILMAZTEPE ORAL, ARZU
dc.contributor.buuauthorCOŞKUN, NECMİYE FUNDA
dc.contributor.buuauthorGözü, R. Oktay
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.
dc.contributor.orcid0000-0002-9027-1132
dc.contributor.orcid0000-0002-8962-9758
dc.contributor.orcid0000-0003-3604-8826
dc.contributor.researcheridDNS-0810-2022
dc.contributor.researcheridAAI-3169-2021
dc.contributor.researcheridAAG-8744-2021
dc.contributor.researcheridA-5841-2017
dc.contributor.researcheridAAD-1271-2019
dc.contributor.researcheridJKV-0503-2023
dc.date.accessioned2024-10-02T13:15:04Z
dc.date.available2024-10-02T13:15:04Z
dc.date.issued2008-01-01
dc.description.abstractVascular endothelial growth factor (VEGF) is a potent mediator of angiogenesis. Increased expression of VEGF may be associated with advanced stage and poor prognosis in patients with lung cancer. We investigated the relationship between serum VEGF level and lung cancer stage. We also studied the correlation between serum VEGF level and some other tumor markers. Forty newly diagnosed lung cancer (31 non-small cell, 9 small cell) patients and 25 age-matched controls were enrolled in this study. Serum VEGF levels of lung cancer group (345.16 +/- 159.36 pg/mL) were significantly higher than that of the control group (230.36 +/- 47.87 pg/mL) (p<0.001). The area under the ROC curve was 0.727 (p<0.05) for serum VEGF threshold of 249.8 pg/mL predictive sensitivity and specificity, for lung cancer were respectively 70.0% and 76.0%. There were no significant relationship between serum VEGF level and age, gender, histologic type, lung cancer stage, distant metastases and site of metastases. In addition, there were no correlation between serum VEGF level and other tumor markers (NSE, CYFRA 21-1, CEA, CA125, LDH)
dc.identifier.endpage55
dc.identifier.issn0494-1373
dc.identifier.issue1
dc.identifier.startpage50
dc.identifier.urihttps://hdl.handle.net/11452/45716
dc.identifier.volume56
dc.identifier.wos000421236800007
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherTurkish Assoc Tuberculosis & Thorax
dc.relation.journalTüberküloz ve Torak-Tuberculosis And Thorax
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSerum vegf
dc.subjectLung cancer
dc.subjectRespiratory system
dc.titleThe evaluation to relationship between serum vascular endothelial growth factor (VEGF) level, metastases and other tumor markers in patients with lung cancer
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery09f93f96-5325-45e7-bf28-4ad8e8c46d6d

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