Publication:
Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease

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dc.contributor.authorWang, Lei
dc.contributor.authorMaher, Timothy John
dc.contributor.authorWurtman, Richard
dc.contributor.buuauthorCansev, Mehmet
dc.contributor.buuauthorUlus, İsmail Hakkı
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmakoloji ve Klinik Farmakoloji Ana Bilim Dalı
dc.contributor.orcid0000-0003-2918-5064
dc.contributor.researcheridD-5340-2015
dc.contributor.researcheridM-9071-2019
dc.contributor.scopusid8872816100
dc.contributor.scopusid7004271086
dc.date.accessioned2021-11-09T07:32:20Z
dc.date.available2021-11-09T07:32:20Z
dc.date.issued2008-11
dc.description.abstractAdministering uridine-5'-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 clays after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may Partially restore dopaminergic neurotransmission in this model of Parkinson's disease.
dc.description.sponsorshipUnited States Department of Health & Human Services (MH-28783) National Institutes of Health (NIH) - USA
dc.description.sponsorshipCenter for Brain Sciences and Metabolism Charitable Trust
dc.description.sponsorshipTürkiye Bilimler Akademisi
dc.description.sponsorshipUnited States Department of Health & Human Services (R37MH028783) National Institutes of Health (NIH) - USA
dc.description.sponsorshipNational Institute of Mental Health (NIMH) (R01MH028783)
dc.identifier.citationCansev, M. vd. (208). ''Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease''. Neuroscience Research, 62(3), 206-209.
dc.identifier.endpage209
dc.identifier.issn0168-0102
dc.identifier.issn1872-8111
dc.identifier.issue3
dc.identifier.pubmed18761383
dc.identifier.scopus2-s2.0-52949131866
dc.identifier.startpage206
dc.identifier.urihttps://doi.org/10.1016/j.neures.2008.07.005
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0168010208002174
dc.identifier.urihttp://hdl.handle.net/11452/22592
dc.identifier.volume62
dc.identifier.wos000260929600008
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt dışı
dc.relation.collaborationSanayi
dc.relation.journalNeuroscience Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectParkinson's disease
dc.subjectUridine
dc.subjectDocosahexaenoic acid
dc.subjectDopamine
dc.subjectTyrosine hydroxylase activity
dc.subjectSynapse
dc.subjectNeurite outgrowth
dc.subjectPartial lesions
dc.subjectFatty-acids
dc.subjectBrain
dc.subjectDopamine
dc.subjectSupplementation
dc.subjectRelease
dc.subjectGerbils
dc.subjectOmega-3
dc.subjectSystem
dc.subjectNeurosciences & neurology
dc.subject.emtreeDexamphetamine
dc.subject.emtreeDocosahexaenoic acid
dc.subject.emtreeDopamine
dc.subject.emtreeOxidopamine
dc.subject.emtreePhospholipid
dc.subject.emtreeSynapsin I
dc.subject.emtreeTyrosine 3 monooxygenase
dc.subject.emtreeUridine phosphate
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeArticle
dc.subject.emtreeCircling behavior
dc.subject.emtreeControlled study
dc.subject.emtreeCorpus striatum
dc.subject.emtreeDopamine metabolism
dc.subject.emtreeDopamine release
dc.subject.emtreeDopaminergic transmission
dc.subject.emtreeDrug effect
dc.subject.emtreeEnzyme activity
dc.subject.emtreeMale
dc.subject.emtreeNonhuman
dc.subject.emtreeParkinson disease
dc.subject.emtreeNeurotransmission
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.emtreeSynaptic membrane
dc.subject.meshAnimals
dc.subject.meshCentral nervous system stimulants
dc.subject.meshCorpus striatum
dc.subject.meshDextroamphetamine
dc.subject.meshDocosahexaenoic acids
dc.subject.meshDopamine
dc.subject.meshFunctional laterality
dc.subject.meshInjections
dc.subject.meshMale
dc.subject.meshNeostriatum
dc.subject.meshOxidopamine
dc.subject.meshParkinson disease
dc.subject.meshSecondary
dc.subject.meshRats
dc.subject.meshRats, sprague-dawley;
dc.subject.meshStereotyped behavior
dc.subject.meshSympatholytics
dc.subject.meshTyrosine 3-monooxygenase
dc.subject.meshUridine
dc.subject.scopusDocosahexaenoic Acids; Omega 3 Fatty Acid; Fish Oils
dc.subject.wosNeurosciences
dc.titleRestorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Farmakoloji ve Klinik Farmakoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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