Publication:
Retrospective evaluation of hemophagocytic lymphohistiocytosis cases treated

dc.contributor.authorTemuroğlu, Aytül
dc.contributor.authorEvim, Melike Sezgin
dc.contributor.authorSevinir, Betül
dc.contributor.authorBaytan, Birol
dc.contributor.authorGüler, Salih
dc.contributor.authorGüneş, Adalet Meral
dc.contributor.buuauthorTEMUROĞLU, AYTÜL
dc.contributor.buuauthorSEZGİN EVİM, MELİKE
dc.contributor.buuauthorSEVİNİR, BETÜL BERRİN
dc.contributor.buuauthorBaytan, Birol
dc.contributor.buuauthorGÜLER, SALİH
dc.contributor.buuauthorMERAL GÜNEŞ, ADALET
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Hematoloji ve Onkoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Hematoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Onkoloji Anabilim Dalı.
dc.contributor.orcid0000-0002-8943-6585
dc.contributor.orcid0000-0002-3232-7652
dc.contributor.orcid0000-0002-9375-2855
dc.contributor.researcheridAAH-1570-2021
dc.contributor.researcheridAAH-1452-2021
dc.contributor.researcheridGES-3112-2022
dc.contributor.researcheridDVW-8108-2022
dc.contributor.researcheridJHO-2788-2023
dc.contributor.researcheridJGX-6145-2023
dc.date.accessioned2024-07-04T11:20:28Z
dc.date.available2024-07-04T11:20:28Z
dc.date.issued2020-04-01
dc.description.abstractINTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is a rare inflammatory syndrome resulting from uncontrolled proliferation in the monocyte / macrophage system. It is divided into two classes as familial (primary) and secondary. Since the rate of consanguineous marriage in our country is high with 29.2%, the frequency of HLH is also increasing. Secondary HLH can be seen at any age, but its true incidence is unknown. It can accompany malignancies, infections and inflammatory processes. Major clinical findings are persistent high fever, cytopenia, splenomegaly and / or hepatomegaly. The first finding is usually fever. The goal of treatment is to stop abnormal inflammation and treat the underlying cause.MATERIALS and METHODS: We retrospectively reviewed 15 patients diagnosed and treated in our clinic between 2010 and 2019. Statistical analysis was performed with kruskal-wallis test.RESULTS: The median age of diagnosis of 15 patients diagnosed and treated in our clinic was 18 months (1 month-17 years). The female to male ratio was 6/9. Fever was seen in all patients, hepatosplenomegaly was 80%. The mean ferritin value was 33.927 +/- 51.461 mu / 1 (964-201.074). In our patient group, consanguineous marriage rate was 53% (n = 8) and it was high and the factor was EBV in all patients who developed secondary to infection. 33% (n 5) of the cases were primary and 67% (n = 10) were secondary. 40% (n = 4) of secondary cases had malignancy in etiology, 50% (n = 5) infection and 10% (n = 1) metabolic disease.CONCLUSIONS: HLH is important for early diagnosis in cases with persistent high fever, hepatosplenomegaly and high ferritin conditions in our country. In cases presenting with HLH, malignancy should not be forgotten in etiology besides primary causes.
dc.identifier.issn1304-9054
dc.identifier.issue1
dc.identifier.urihttps://hdl.handle.net/11452/42905
dc.identifier.volume18
dc.identifier.wos000527262100013
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherGalenos Yayıncılık
dc.relation.journalGuncel Pediatri-Journal of Current Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSpectrum
dc.subjectChildren
dc.subjectHemophagocytic lymphohistiocytosis
dc.subjectCytopenia
dc.subjectHepatosplenomegaly
dc.subjectPediatrics
dc.titleRetrospective evaluation of hemophagocytic lymphohistiocytosis cases treated
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery2f25a9aa-6502-4463-9f09-9380f63cc30a

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