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Histological assessment of the effect of alpha-tocopherol on fracture healing in rabbits

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dc.contributor.authorÖzkan, S.
dc.contributor.buuauthorDurak, Kemal
dc.contributor.buuauthorSönmez, Gürsel
dc.contributor.buuauthorSarısözen, Bartu
dc.contributor.buuauthorKaya, Metin
dc.contributor.buuauthorÖztürk, Çaǧatay
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentCerrahi Ana Bilim Dalı
dc.contributor.departmentOrtopedi ve Travmatoloji Ana Bilim Dalı
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.orcid0000-0003-3133-206X
dc.contributor.researcheridABI-7283-2020
dc.contributor.researcheridAAP-7233-2020
dc.contributor.researcheridS-6686-2019
dc.contributor.scopusid6602850051
dc.contributor.scopusid55167435000
dc.contributor.scopusid55890736200
dc.contributor.scopusid55417963000
dc.contributor.scopusid8230555600
dc.date.accessioned2022-03-30T08:22:13Z
dc.date.available2022-03-30T08:22:13Z
dc.date.issued2003-01
dc.description.abstractTo investigate the effect of alpha-tocopherol (vitamin E) on fracture healing in rabbits, two groups of 10 rabbits were either injected with alpha-tocopherol (treated) or untreated (controls). The right femurs of both groups were fractured, and the treated group were injected intramuscularly with 20 mg/kg alpha-tocopherol daily for 5 days starting on the day of fracture. After 21 days, histological sections of the fractured region were examined and scored. Fracture healing had progressed further in the alpha-tocopherol group than in the control group. A statistically significant difference between the histological grading of fracture healing in the two groups was found. This difference may result from an antioxidant (alpha-tocopherol) effect on free oxygen radicals in the fracture area. We conclude that alpha-tocopherol may affect fracture healing favourably and might be useful as a therapeutic agent in clinical fracture management.
dc.identifier.citationDurak, K. vd. (2003). “Histological assessment of the effect of alpha-tocopherol on fracture healing in rabbits”. Journal of International Medical Research, 31(1), 26-30.
dc.identifier.doi10.1177/147323000303100104
dc.identifier.endpage30
dc.identifier.issn0300-0605
dc.identifier.issue1
dc.identifier.pubmed12635530
dc.identifier.scopus2-s2.0-0037226366
dc.identifier.startpage26
dc.identifier.urihttps://doi.org/10.1177/147323000303100104
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/147323000303100104
dc.identifier.urihttp://hdl.handle.net/11452/25432
dc.identifier.volume31
dc.identifier.wos000181291300004
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSage Publications
dc.relation.collaborationYurt içi
dc.relation.journalJournal of International Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectResearch and experimental medicine
dc.subjectPharmacology and pharmacy
dc.subjectAlpha-tocopherol
dc.subjectVitamin E
dc.subjectAntioxidant
dc.subjectFracture healing
dc.subjectRabbit
dc.subjectHistological assessment
dc.subjectOxygen-free-radicals
dc.subjectVitamin-C
dc.subjectTissue
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeControlled study
dc.subject.emtreeDose response
dc.subject.emtreeDrug effect
dc.subject.emtreeDrug use
dc.subject.emtreeFemur fracture
dc.subject.emtreeFracture healing
dc.subject.emtreeHistopathology
dc.subject.emtreeMale
dc.subject.emtreeNonhuman
dc.subject.emtreeRabbit
dc.subject.emtreeScoring system
dc.subject.emtreeStatistical analysis
dc.subject.emtreeTissue section
dc.subject.emtreeAlpha tocopherol
dc.subject.emtreeAntioxidant
dc.subject.emtreeFree radical
dc.subject.emtreeOxygen
dc.subject.scopusFracture Healing; Ovx; Osteoporosis
dc.subject.wosMedicine, research and experimental
dc.subject.wosPharmacology and pharmacy
dc.titleHistological assessment of the effect of alpha-tocopherol on fracture healing in rabbits
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Ortopedi ve Travmatoloji Ana Bilim Dalı
local.contributor.departmentVeteriner Fakültesi/Cerrahi Ana Bilim Dalı
local.contributor.departmentVeteriner Fakültesi/Patoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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