Publication:
In vivo exposure of Albendazole sulphoxide by Haemonchus contortus and correlation between plasma and target tissue or gastrointestinal content dispositions in goats

dc.contributor.authorGökbulut, Cengiz
dc.contributor.authorÇırak, Veli Y.
dc.contributor.authorAypak, Süleyman
dc.contributor.authorAvcı, Hamdi
dc.contributor.authorSekkin, Selim
dc.contributor.authorYalınkılınç, Hande S.
dc.contributor.authorBoğa, Buket
dc.contributor.authorAyaz, Erol
dc.contributor.buuauthorÇIRAK, VELİ YILGÖR
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi/Parazitoloji Anabilim Dalı.
dc.contributor.researcheridFYC-2043-2022
dc.date.accessioned2024-10-24T10:40:31Z
dc.date.available2024-10-24T10:40:31Z
dc.date.issued2021-04-24
dc.description.abstractSheep and goats are sharing different helminth parasites including Haemonchus contortus. Control of these helminths is based mainly on the use of anthelmintics. However, in goats, the application of anthelmintics is often carried out mainly at dosages determined for sheep without knowing the real effects and metabolism features. One of the several anthelmintic classes used against these parasites is (pro) benzimidazoles which are still widely in use in small ruminants in many countries. The objective of this study was to determine (i) the correlation between plasma and tissue or gastrointestinal content dispositions of ricobendazole (RBZ) in goats and (ii) the in vivo exposure of ricobendazole by H. contortus. Ten goats were experimentally infected with 10,000 larvae of H. contortus. Four weeks of post-infection, the animals received RBZ subcutaneously at 5 mg/kg body weight. Two goats were sacrificed per time at 1, 2, 4, 6 and 12 h after drug administration and, blood, bile, urine, liver, lung, muscle and kidney gastrointestinal tissues/fluids were collected. Adult H. contortus were collected from abomasum, and all samples were analysed by HPLC system. Ricobendazole (RBZ) and its sulphone metabolite were extensively excreted by urine and distributed to all tissues and digestive tract, mainly into the abomasum fluid. RBZ concentration in the lung and ABZSO(2) in the kidney were relatively higher than those of other tissues, respectively. The parent drug and its metabolite were recovered in both male and female H. contortus. This study indicates that in goats the plasma concentration profiles of RBZ are strongly correlated with those achieved in different target tissues or fluids, which in turn, reflect the amount of drug taken up by parasites.
dc.identifier.doi10.1111/jvp.12974
dc.identifier.endpage807
dc.identifier.issn0140-7783
dc.identifier.issue5
dc.identifier.startpage799
dc.identifier.urihttps://doi.org/10.1111/jvp.12974
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/jvp.12974
dc.identifier.urihttps://hdl.handle.net/11452/47012
dc.identifier.volume44
dc.identifier.wos000643136100001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWiley
dc.relation.journalJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak109 O 862
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPharmacokinetic behavior
dc.subjectRicobendazole
dc.subjectSheep
dc.subjectMetabolites
dc.subjectEnantiomers
dc.subjectResistance
dc.subjectAnthelmintics
dc.subjectFormulation
dc.subjectParasites
dc.subjectExcretion
dc.subjectAlbendazole sulphoxide
dc.subjectBenzimidazoles
dc.subjectGoat
dc.subjectHaemonchus contortus
dc.subjectRicobendazole
dc.subjectPharmacology & pharmacy
dc.subjectVeterinary sciences
dc.titleIn vivo exposure of Albendazole sulphoxide by Haemonchus contortus and correlation between plasma and target tissue or gastrointestinal content dispositions in goats
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication05bf05d0-3c21-4f10-9398-2ac88d28364b
relation.isAuthorOfPublication.latestForDiscovery05bf05d0-3c21-4f10-9398-2ac88d28364b

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