Publication:
Biomarker potential of urine miR-451 at different stages of diabetic nephropathy

dc.contributor.authorSayılar, Emel Işıktaş
dc.contributor.authorGüllülü, Mustafa
dc.contributor.authorTuncel, Ercan
dc.contributor.authorPeynirci, Hande
dc.contributor.authorAlemdar, Adem
dc.contributor.authorTunca, Berrin
dc.contributor.authorEgeli, Ünal
dc.contributor.authorÇeçener, Gülşah
dc.contributor.authorBayındır, Murat
dc.contributor.authorCoşgun, Gökhan
dc.contributor.buuauthorSayılar, Emel Işıktaş
dc.contributor.buuauthorGÜLLÜLÜ, MUSTAFA
dc.contributor.buuauthorTuncel, Ercan
dc.contributor.buuauthorPeynirci, Hande
dc.contributor.buuauthorALEMDAR, ADEM
dc.contributor.buuauthorTUNCA, BERRİN
dc.contributor.buuauthorEGELİ, ÜNAL
dc.contributor.buuauthorÇEÇENER, GÜLŞAH
dc.contributor.buuauthorBayındır, Murat
dc.contributor.buuauthorCoşgun, Gökhan
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı.
dc.contributor.orcid0000-0002-1619-6680
dc.contributor.orcid0000-0001-7904-883X
dc.contributor.orcid0000-0002-3820-424X
dc.contributor.researcheridW-2575-2017
dc.contributor.researcheridCTG-8811-2022
dc.contributor.researcheridEBN-7188-2022
dc.contributor.researcheridGRY-0605-2022
dc.contributor.researcheridELA-3536-2022
dc.contributor.researcheridABI-6078-2020
dc.contributor.researcheridAAH-1420-2021
dc.contributor.researcheridAAP-9988-2020
dc.contributor.researcheridCFN-0933-2022
dc.contributor.researcheridERH-7786-2022
dc.date.accessioned2024-10-01T05:35:23Z
dc.date.available2024-10-01T05:35:23Z
dc.date.issued2016-02-01
dc.description.abstractAims: To evaluate the potential of urinary miR-451 as a biomarker at different stages of diabetic nephropathy.Methods: A total of 45 subjects having stage 3 chronic kidney disease (n=15) or stage 5 chronic kidney disease (n=15) and 15 healthy volunteers were included. Data on patient demographics, laboratory findings [creatinine, estimated glomerular filtration rate, urinary protein excretion] target genes and functions of the selected MicroRNAs associated with diabetic nephropathy and fold differences in the level of MicroRNA expression in blood and urine and the correlation of urine and plasma MicroRNA expression with estimated glomerular filtration rate were recorded.Results: MiR-195 expression level among stage 3 chronic kidney disease patients was higher in plasma samples compared to the control group, while it was significantly lower in the urine samples (p=0.036). In the stage 5 chronic kidney disease patient group, while the expression level was significantly higher in the plasma samples (p=0.005), urine sample expression was lower but not significantly different than the control group. Compared to the controls, miR-451 expression level was higher in the plasma samples of stage 3 chronic kidney disease patients, but significantly lower in the urine samples (p=0.019). Among the stage 5 chronic kidney disease patients, there was significantly higher level of expression in plasma samples (p=0.007) and significantly lower expression in urine samples (p=0.022) than the control group.Conclusions: Our study is original with its investigation of MicroRNA expressions at different stages of chronic kidney disease. Especially the statistically significant changes in the expression of miR-195 and miR-451 make these MicroRNAs come forward as good noninvasive biomarker candidates.
dc.description.sponsorshipBursa Böbrek Vakfı
dc.identifier.doi10.4172/2155-6156.1000650
dc.identifier.issn2155-6156
dc.identifier.issue2
dc.identifier.urihttps://doi.org/10.4172/2155-6156.1000650
dc.identifier.urihttps://hdl.handle.net/11452/45548
dc.identifier.volume7
dc.identifier.wos000384464600007
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherOmics Int Pvt Ltd
dc.relation.journalJournal of Diabetes & Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGrowth-factor-beta
dc.subjectRenal fibrosis
dc.subjectHigh glucose
dc.subjectExpression
dc.subjectMicrornas
dc.subjectComplications
dc.subjectHypertrophy
dc.subjectApoptosis
dc.subjectInjury
dc.subjectSerum
dc.subjectChronic kidney disease
dc.subjectMicrorna expression
dc.subjectPlasma
dc.subjectUrine
dc.subjectDiabetic nephropathy
dc.subjectEndocrinology & metabolism
dc.titleBiomarker potential of urine miR-451 at different stages of diabetic nephropathy
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery47f5ec68-c479-4f62-9aed-37ba604a689c

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