Publication:
Caloric restriction in lean and obese strains of laboratory rat: Effects on body composition, metabolism, growth and overall health

dc.contributor.authorAydın, Cenk
dc.contributor.authorJarema, K. A.
dc.contributor.authorPhillips, P. M.
dc.contributor.authorGordon, C. J.
dc.contributor.buuauthorAYDIN, CENK
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı
dc.contributor.researcheridCCF-5728-2022
dc.date.accessioned2024-08-02T07:13:28Z
dc.date.available2024-08-02T07:13:28Z
dc.date.issued2015-11-01
dc.description.abstractNew FindingsWhat is the central question of this study? How do lean and obese rats respond physiologically to caloric restriction?What is the main finding and its importance? Obese rats show marked benefits compared with lean animals.Reduced body fat is associated with improved longevity with caloric restriction (CR) in rodents. Little is known regarding effects of CR in genetically lean versus obese strains. Long-Evans (LE) and Brown Norway (BN) rats make an ideal comparison for a CR study because the percentage body fat of young adult LE rats is double that of BN rats. Male LE and BN rats were either fed ad libitum (AL) or were calorically restricted to 80 or 90% of their AL weight. The percentages of fat, lean and fluid mass were measured non-invasively at 2- to 4-week intervals. Metabolic rate and respiratory quotient were measured after 3, 6, 9 and 12months of CR. Overall health was scored monthly. The percentage of fat of the LE strain decreased with CR, whereas the percentage of fat of the BN strain remained above the AL group for several months. The percentage of lean mass increased above the AL for both strains subjected to CR. The percentage of fluid was unaffected by CR. The average metabolic rate over 22h of the BN rats subjected to CR was reduced, whereas that of LE rats was increased slightly above the AL group. The respiratory quotient of BN rats was decreased with CR. Overall health of the CR LE group was significantly improved compared with that of the AL group, whereas health of the CR BN rats was impaired compared with the AL group. Overall, the lean BN and obese LE strains differ markedly in fat utilization and metabolic response to prolonged CR. There appears to be little benefit of CR in the lean strain.
dc.identifier.doi10.1113/EP085469
dc.identifier.eissn1469-445X
dc.identifier.endpage1297
dc.identifier.issn0958-0670
dc.identifier.issue11
dc.identifier.startpage1280
dc.identifier.urihttps://doi.org/10.1113/EP085469
dc.identifier.urihttps://physoc.onlinelibrary.wiley.com/doi/10.1113/EP085469
dc.identifier.urihttps://hdl.handle.net/11452/43653
dc.identifier.volume100
dc.identifier.wos000365117400009
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWiley
dc.relation.journalExperimental Physiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEnergy-expenditure
dc.subjectRhesus-monkeys
dc.subjectLongevity
dc.subjectAdult
dc.subjectTemperature
dc.subjectWeight
dc.subjectLife
dc.subjectMass
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectPhysiology
dc.titleCaloric restriction in lean and obese strains of laboratory rat: Effects on body composition, metabolism, growth and overall health
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationd9572bb0-4cba-4177-9bf8-8463d30dcfdb
relation.isAuthorOfPublication.latestForDiscoveryd9572bb0-4cba-4177-9bf8-8463d30dcfdb

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