Publication:
Serum mindin, nephrin and podocalyxin levels in patients with type 1 diabetes: Are these new markers to detect the development of nephropathy?

dc.contributor.authorSambel, Irmak Tanal
dc.contributor.buuauthorEren, Erdal
dc.contributor.buuauthorEREN, ERDAL
dc.contributor.buuauthorSARANDÖL, EMRE
dc.contributor.buuauthorBozyiğit, Cengiz
dc.contributor.buuauthorBOZYİĞİT, CENGİZ
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.
dc.contributor.orcid0000-0002-1684-1053
dc.contributor.orcid0000-0003-2215-6973
dc.contributor.orcid0000-0002-2593-7196
dc.contributor.researcheridJPK-3909-2023
dc.date.accessioned2024-11-07T05:58:37Z
dc.date.available2024-11-07T05:58:37Z
dc.date.issued2022-08-01
dc.description.abstractIntroduction: Type 1 diabetes mellitus (DM) is a chronic disease that develops as a result of absolute insulin deficiency. DM is accompanied by chronic complications which are associated with a high risk of morbidity and mortality. In the present study, we aimed to understand whether serum mindin, nephrin (NPHS1) and podocalyxin (PODXL) are useful biomarkers in the determination of nephropathy in patients with type 1 DM and to understand any correlation between serum mindin, PODXL, nephrin levels and hemoglobin A1c (HbA1c) levels and 24 hour urinary albumin excretion of patients. We investigated serum PODXL, nephrin and mindin levels in pediatric patients with type 1 DM.Materials and Methods: Forty patients with type 1 DM along with controls, all in the pubertal stage, were included in the study. Serum mindin, nephrin and PODXL levels were measured using commercial ELISA kits. In the DM group, the mean age, gender distribution, follow-up time, and HbA1c levels were evaluated.Results: There was no significant difference in the serum mindin levels between the DM and control groups (p=0.053). When the serum nephrin levels were compared between the two groups, the nephrin levels were significantly lower in the DM group (p=0.016). The serum PODXL levels of the DM group were significantly lower when compared to the control group (p=0.014).Conclusion: We found that the blood levels of nephrin, PODXL were decreased in the DM group. These markers can be excreted in urine and may be sensitive markers for DM. This is the first study in the literature to evaluate PODXL, mindin, nephrin biomarkers in pediatric patients with type 1 DM.
dc.identifier.doi10.4274/jcp.2022.34635
dc.identifier.endpage154
dc.identifier.issn1304-9054
dc.identifier.issue2
dc.identifier.startpage147
dc.identifier.urihttps://doi.org/10.4274/jcp.2022.34635
dc.identifier.urihttps://hdl.handle.net/11452/47528
dc.identifier.volume20
dc.identifier.wos000965716700006
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.journalGuncel Pediatri-journal Of Current Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiabetes mellitus
dc.subjectMindin
dc.subjectPodocalyxin
dc.subjectNephrin
dc.subjectDiabetic nephropathy
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectPediatrics
dc.titleSerum mindin, nephrin and podocalyxin levels in patients with type 1 diabetes: Are these new markers to detect the development of nephropathy?
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication2d1c6521-88a9-4270-9918-92f16f98006c
relation.isAuthorOfPublication9529fb52-20cd-4fb3-9767-19121683aa62
relation.isAuthorOfPublication6faaaad1-b377-4a77-9990-df58cd699dcd
relation.isAuthorOfPublication.latestForDiscovery2d1c6521-88a9-4270-9918-92f16f98006c

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