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Evaluation of the trend of biochemical functions in the early period after cadaveric liver transplantation

dc.contributor.authorAksoy, Fuat
dc.contributor.authorGürlüler, Ercüment
dc.contributor.authorÇelik, Fatih
dc.contributor.authorŞen, Murat
dc.contributor.authorBalkan, Eyüp Anıl
dc.contributor.authorDündar, Halit Ziya
dc.contributor.authorKaya, Ekrem
dc.contributor.buuauthorAKSOY, FUAT
dc.contributor.buuauthorGÜRLÜLER, ERCÜMENT
dc.contributor.buuauthorÇELİK, FATİH
dc.contributor.buuauthorŞEN, MURAT
dc.contributor.buuauthorBALKAN, EYÜP ANIL
dc.contributor.buuauthorDÜNDAR, HALİT ZİYA
dc.contributor.buuauthorKAYA, EKREM
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Organ Nakli Merkezi.
dc.contributor.orcid0000-0001-5808-9384
dc.contributor.orcid0000-0003-2728-9521
dc.contributor.researcheridHII-8895-2022
dc.contributor.researcheridX-7425-2018
dc.contributor.researcheridAAG-7319-2021
dc.contributor.researcheridJYY-5340-2024
dc.contributor.researcheridJEX-7100-2023
dc.contributor.researcheridIZR-9309-2023
dc.contributor.researcheridEWI-3634-2022
dc.date.accessioned2024-10-22T12:49:48Z
dc.date.available2024-10-22T12:49:48Z
dc.date.issued2023-06-28
dc.description.abstractBackground. Monitoring biochemical parameters to detect early complications after liver transplantation (LT) is important. Thus, we aimed to investigate parameter trends indicating liver function in patients who did not develop complications after cadaveric LT. Methods. A total of 266 cadaveric LT operations performed by a single center between 2007-2022 were included in the study. Patients with any early complications were excluded from the study. During the first 15 days, the parameters reflecting the patients' liver integrity and synthesis functions were evaluated. All parameters studied were evaluated at the same time of day and by a single laboratory. Results. Regarding synthesis functions, the coagulation parameters (prothrombin time and international normalized ratio) peaked on the first day and then decreased. Regarding tissue hypoxia, there was no significant change in lactate values. Total and direct bilirubin values also decreased after peaking on the first day. No significant change was observed in albumin, another liver synthesis value. Conclusions. Although an increase in aspartate aminotransferase, alanine aminotransferase, total and direct bilirubin, prothrombin time, and international normalized ratio, which was especially seen on the first day, is considered normal, values that do not decrease after the second day or lactate values that increase gradually should be a warning in terms of possible early complications.
dc.identifier.doi10.1016/j.transproceed.2023.03.040
dc.identifier.endpage1256
dc.identifier.issn0041-1345
dc.identifier.issue5
dc.identifier.startpage1252
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2023.03.040
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0041134523002075?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11452/46862
dc.identifier.volume55
dc.identifier.wos001035777600001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.journalTransplantation Proceedings
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLactate
dc.subjectImmunology
dc.subjectSurgery
dc.subjectTransplantation
dc.titleEvaluation of the trend of biochemical functions in the early period after cadaveric liver transplantation
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery9188647a-59b3-41bd-be73-594de198226a

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